A new sighting study for the fixed concentration procedure to allow for gender differences

Human and Experimental Toxicology

Volumn 30, Issue 3, 2011, Pages 239-249

  Stallard, Nigel ^a   Price, Charlotte ^a   Creton, Stuart ^b   Indans, Ian ^c   Guest, Robert ^d   Griffiths, David ^d   Edwards, Philippa ^e  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b National Centre for the Replacement   (United Kingdom)

^c HEALTH AND SAFETY EXECUTIVE   (United Kingdom)

^d Harlan   (Switzerland)

^e PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

acute inhalation toxicity; fixed concentration procedure; gender differences; OECD Test Guidelines

Indexed keywords

ACUTE INHALATION TOXICITY; ACUTE TOXICITY; ARTICLE; CAUSE OF DEATH; FEMALE; FIXED CONCENTRATION PROCEDURE; LC 50; MALE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEX DIFFERENCE;

ACUTE TOXICITY TESTS; ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUST; FEMALE; MALE; SEX CHARACTERISTICS;

ANIMALIA;

EID: 79951929965     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110370983     Document Type: Article

References (7)

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2. OECD. Guidelines for the testing of chemical substances. No. 436. Acute inhalation toxicity - acute toxic class method. Paris, 2009.
3. OECD. Guidelines for testing of chemical substances. Draft No. 433. Acute inhalation toxicity - fixed concentration procedure. Paris, 2004.
4. Stallard N, Whitehead A, Indans I. Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment. Hum Exp Toxicol 2003; 22: 575-585. (Pubitemid 37536776)
5. Price C, Stallard N, Creton S, et al. A statistical evaluation of the effects of gender differences in assessment of acute inhalation toxicity. HumExp Toxicol 2010. DOI 10.1177/0960327110370982.
6. OECD. Harmonized integrated hazard classification system for human health and environmental effects of chemical substances. Paris, 1998.
7. Greiner M. 'Report on biostatistical performance assessment of draft TG 436 acute toxic class method for acute inhalation toxicity,' 2008, http://www. oecd.org/LongAbstract/0,3425,en-33873108-33844437-41762050-1-1-1-1,00.html (2008). Accessed 23 April 2010.