Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment

Human and Experimental Toxicology

Volumn 22, Issue 11, 2003, Pages 575-585

  Stallard, Nigel ^a   Whitehead, Anne ^a   Indans, Ian ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b HEALTH AND SAFETY EXECUTIVE   (United Kingdom)

Author keywords

Acute inhalation toxicity testing; LC50 test; Median lethal concentration; OECD Test Guideline 403

Indexed keywords

ACUTE TOXICITY; AIR POLLUTION; ARTICLE; CLASSIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; IN VIVO STUDY; INHALATION; LC 50; MALE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; SIMULATION; STATISTICAL ANALYSIS; TOXICITY TESTING; VALIDATION PROCESS;

ANIMAL WELFARE; ANIMALS; ANIMALS, LABORATORY; ENDPOINT DETERMINATION; GUIDELINES; INHALATION EXPOSURE; LETHAL DOSE 50; MODELS, STATISTICAL; REFERENCE VALUES;

ANIMALIA;

EID: 0346147019     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327103ht395oa     Document Type: Article

References (9)

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3. OECD. Guidelines for the testing of chemical substances. No. 401. Acute oral toxicity. Paris: OECD, 1987.
4. OECD. Guidelines for the testing of chemical substances. No. 420. Acute oral toxicity - fixed dose method. Paris: OECD, 2000.
5. OECD. Guidelines for the testing of chemical substances. No. 423, Acute oral toxicity - acute toxic class method. Paris: OECD, 2000.
6. OECD. Guidelines for the testing of chemical substances. No. 425. Acute oral toxicity - up and down method. Paris: OECD, 2000.
7. Russell WMS, Burch RL. The principles of humane experimental technique. London: Methuen, 1959.
8. Warbrick EV, Indans I, Blackwell M, Hardy CJ, Shepherd N. The reduction and refinement of animal use in acute inhalation toxicity testing. In press.
9. Stallard N, Whitehead A, Ridgway P. Statistical evaluation of the revised fixed dose procedure. Hum Exp Toxicol 2002; 21: 183-96.