Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in down syndrome

Journal of Alzheimer's Disease

Volumn 23, Issue 3, 2011, Pages 399-409

  Head, Elizabeth ^a,b,c   Doran, Eric ^a,b   Nistor, Mihaela ^a   Hill, Maryann ^a,b   Schmitt, Frederick A ^c   Haier, Richard J ^a,b   Lott, Ira T ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Apolipoprotein E; cognition; mental status; neuropsychology; trisomy 21

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DOWN SYNDROME; FEMALE; GENOTYPE; HUMAN; INTELLECTUAL IMPAIRMENT; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 79951873364     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-101335     Document Type: Article

References (54)

1. Mann DMA (1988) The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Devel 43, 99-136.
2. Mann DMA, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci 89, 169-179. (Pubitemid 19052948)
3. Wisniewski K, Wisniewski H, Wen G (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 17, 278-282. (Pubitemid 15136603)
4. Hof PR, Bouras C, PerlDP, Sparks DL, Mehta N, Morrison JH (1995) Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Arch Neurol 52, 379-391.
5. Lai F,WilliamsMD(1989) A prospective study of Alzheimer Disease in Down syndrome. Arch Neurol 46, 849-853. (Pubitemid 19199367)
6. Lott IT, Head E (2001) Down syndrome and Alzheimer's disease: a link between development and aging. Ment RetardDev Disabil Res Rev 7, 172-178. (Pubitemid 32843808)
7. Tyrrell J, Cosgrave M, McCarron M, McPherson J, Calvert J, Kelly A, McLaughlin M, Gill M, LawlorBA(2001) Dementia in people with Down's syndrome. Int J Geriatr Psychiatry 16, 1168-1174. (Pubitemid 34044185)
8. Prasher VP, Filer A (1995) Behavioural disturbance in people with Down's syndrome and dementia. J Intellect Disabil Res 39, 432-436.
9. Bush A, Beail N (2004) Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis. Am J Ment Retard 109, 83-97.
10. Wisniewski K, Howe J, Williams G and Wisniewski HM (1978) Precocious aging and dementia in patients with Down's syndrome. Biol Psychiatry 13, 619-627. (Pubitemid 9041470)
11. Rumble B, Retallack R, Hilbich C, Simms G, Multhaup G, Martins R, Hockey A, Montgomery P, Beyreuther K, Masters CL (1989) Amyloid A4 and its precursor in Down's syndrome and Alzheimer's disease. New Engl J Med 320, 1446-1462.
12. Pallister C, Jung SS, Shaw I, Nalbantoglu J, Gauthier S, Cashman NR (1997) Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging. Neurobiol Aging 18, 97-103. (Pubitemid 27062191)
13. Selkoe DJ (1994) Normal and abnormal biology of the betaamyloid precursor protein. Annu Rev Neurosci 17, 489-517. (Pubitemid 24117040)
14. Cavani S, Tamaoka A, Moretti A, Marinelli L, Angelini G, Di Stefano S, Piombo G, Cazzulo V, Matsuno S, Shoji S, Furiya Y, Zaccheo D, Dagna-Bricarelli F, Tabaton M, Mori H (2000) Plasma levels of amyloid β 40 and 42 are independent from ApoE genotype and mental retardation in Down syndrome. Am J Med Genet 95, 224-228.
15. Mehta PD, Dalton AJ, Mehta SP, Kim KS, Sersen EA, Wisniewski HM (1998) Increased plasma amyloid β protein 1-42 levels in Down syndrome. Neurosci Lett 241, 13-16. (Pubitemid 28079022)
16. Mehta PD, Mehta SP, Fedor B, Patrick BA, Emmerling M, Dalton AJ (2003) Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome. Neurosci Lett 342, 155-158. (Pubitemid 36570341)
17. Tokuda T, Fukushima T, Ikeda S, Sekijima Y, Shoji S, Yanagisawa N, Tamaoka A (1997) Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome. Ann Neurol 41, 271-273. (Pubitemid 27082110)
18. Blennow K (2004) Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx 1, 213-225. (Pubitemid 46589353)
19. Head E, Lott IT (2004) Down syndrome and beta-amyloid deposition. Curr Opin Neurol 17, 95-100. (Pubitemid 38446448)
20. Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E (2007) Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiol Aging 28, 1493-1506. (Pubitemid 47238529)
21. Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M (2004) Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25, 833-841. (Pubitemid 38813163)
22. Schupf N, Patel B, Silverman W, Zigman WB, Zhong N, Tycko B,Mehta PD, Mayeux R (2001) Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome. Neurosci Lett 301, 199-203. (Pubitemid 32226434)
23. PrasherVP, Sajith SG, Mehta P, ZigmanWB,SchupfN(2010) Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome. Int J Geriatr Psychiatry 25, 202-207.
24. Schupf N, Patel B, Pang D, Zigman WB, SilvermanW, Mehta PD, Mayeux R (2007) Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome. Arch Neurol 64, 1007-1013. (Pubitemid 47048002)
25. Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC (2003) Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol 60, 958-964. (Pubitemid 36858355)
26. Mehta PD, Pirttila T, Mehta SP, Sersen EA, Aisen PS, Wisniewski HM (2000) Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol 57, 100-105. (Pubitemid 30027637)
27. Kawarabayashi T, Shoji M (2008) Plasma biomarkers of Alzheimer's disease. Curr Opin Psychiatry 21, 260-267. (Pubitemid 351489346)
28. Haier RJ, Alkire MT,White NS, Uncapher MR, Head E, Lott IT, Cotman CW (2003) Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology 61, 1673-1679. (Pubitemid 38020810)
29. Haier RJ, Head K, Head E, Lott IT (2008) Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events. Neuroimage 39, 1324-1332.
30. Sano MC, Aisen PS, Dalton AJ, Andrews HF, Tsai W-Y, Consortium IDSAD (2005) Assessment of aging individuals with Down syndrome in clinical trials: Preliminary results of baseline evaluations. J Policy Pract Intellect Disabil 2, 126-138.
31. Panisset M, Roudier M, Saxton J, Boller F (1994) Severe impairment battery. A neuropsychological test for severely demented patients. Arch Neurol 51, 41-45. (Pubitemid 24020169)
32. Evenhuis HM (1992) Evaluation of a screening instrument for dementia in ageing mentally retarded persons. J Intellect Disabil Res 36, 337-347.
33. Evenhuis HM (1996) Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR). J Intellect Disabil Res 40, 369-373. (Pubitemid 26317071)
34. Association AP (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th ed. American Psychiatric Association, Washington, DC.
35. Black SC, Hewett S, Kotubi Y, Brunt RV, Reckless JP (1990) Isoform patterns of apolipoprotein E in diabetes mellitus. Diabet Med 7, 532-539. (Pubitemid 20199800)
36. Ossendorf M, Prellwitz W (2000) Rapid and easy apoliprotein E genotyping using an improved PCR-RFLP technique. QiageNews 1, 11-12.
37. Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE, Younkin SG (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264, 1336-1340.
38. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13, 45.
39. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy- Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [see comments]. Nat Med 2, 864-870. (Pubitemid 26296755)
40. Matsuoka Y, Andrews HF, Becker AG, Gray AJ, Mehta PD, Sano MC, Dalton AJ, Aisen PS (2009) The relationship of plasma Abeta levels to dementia in aging individuals with down syndrome. Alzheimer Dis Assoc Disord 23, 315-318.
41. Lai F, Williams RS (1989) A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 46, 849-853. (Pubitemid 19199367)
42. Pesaresi M, Lovati C, Bertora P, Mailland E, Galimberti D, Scarpini E, Quadri P, Forloni G, Mariani C (2006) Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 27, 904-905. (Pubitemid 44287903)
43. Mehta PD, Capone G, Jewell A, Freedland RL (2007) Increased amyloid beta protein levels in children and adolescents with Down syndrome. J Neurol Sci 254, 22-27. (Pubitemid 46330403)
44. Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC (2007) Plasma Ab does not reflect brain Ab levels. J Neuropathol Exp Neurol 66, 264-271. (Pubitemid 46559019)
45. Jones EL, HanneyM, Francis PT, BallardCG(2009) Amyloid beta concentrations in older people with Down syndrome and dementia. Neurosci Lett 451, 162-164.
46. Schupf N, Kapell D, Lee JH, Zigman W, Canto B, Tycko B, Mayeux R (1996) Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome. Ann Neurol 40, 799-801. (Pubitemid 26415194)
47. Schupf N, Sergievsky GH (2002) Genetic and host factors for dementia in Down's syndrome. Br J Psychiatry 180, 405-410. (Pubitemid 34499334)
48. Hoglund K, Wiklund O, Vanderstichele H, Eikenberg O, Vanmechelen E, Blennow K (2004) Plasma levels of betaamyloid( 1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol 61, 333-337. (Pubitemid 38327348)
49. Blasko I, Kemmler G, Krampla W, Jungwirth S, Wichart I, Jellinger K, Tragl KH, Fischer P (2005) Plasma amyloid beta protein 42 in non-demented persons aged 75 years: effects of concomitant medication and medial temporal lobe atrophy. Neurobiol Aging 26, 1135-1143. (Pubitemid 40726005)
50. Mayeux R, Tang MX, Jacobs DM, Manly J, Bell K, Merchant C, Small SA, Stern Y, Wisniewski HM, Mehta PD (1999) Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. Ann Neurol 46, 412-416. (Pubitemid 29416281)
51. Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ (1996) Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem 271, 32916-32922. (Pubitemid 27008725)
52. Hammad SM, Ranganathan S, Loukinova E, Twal WO, Argraves WS (1997) Interaction of apolipoprotein Jamyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem 272, 18644-18649. (Pubitemid 27318206)
53. Conti E, Galimberti G, Piazza F, Raggi ME, Ferrarese C (2009) Increased soluble APPalpha, Abeta 1-42, and anti- Abeta 1-42 antibodies in plasma from Down syndrome patients. Alzheimer Dis Assoc Disord 24, 96-100.
54. Kuo YM, Kokjohn TA, Watson MD, Woods AS, Cotter RJ, Sue LI, Kalback WM, Emmerling MR, Beach TG, Roher AE (2000) Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism. Am J Pathol 156, 797-805. (Pubitemid 30626937)