메뉴 건너뛰기




Volumn 18, Issue 2, 2011, Pages 198-209

Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; CARBOHYDRATE; FLAVIPUCINE; LEUCINE; MYCOTOXIN; POLYKETIDE SYNTHASE; PYRIDONE DERIVATIVE;

EID: 79951857052     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.12.011     Document Type: Article
Times cited : (86)

References (51)
  • 1
    • 3442896886 scopus 로고    scopus 로고
    • NRPS-PKS: A knowledge-based resource for analysis of NRPS-PKS megasynthases
    • DOI 10.1093/nar/gkh359
    • M.Z. Ansari, G. Yadav, R.S. Gokhale, and D. Mohanty NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases Nucleic Acids Res. 32 2004 W405 W413 (Pubitemid 39004076)
    • (2004) Nucleic Acids Research , vol.32 , Issue.WEB SERVER ISS.
    • Ansari, M.Z.1    Yadav, G.2    Gokhale, R.S.3    Mohanty, D.4
  • 2
    • 0029888607 scopus 로고    scopus 로고
    • Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans
    • K.T. Bergh, O. Litzka, and A.A. Brakhage Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans J. Bacteriol. 178 1996 3908 3916 (Pubitemid 26227209)
    • (1996) Journal of Bacteriology , vol.178 , Issue.13 , pp. 3908-3916
    • Bergh, K.T.1    Litzka, O.2    Brakhage, A.A.3
  • 3
    • 33947308882 scopus 로고    scopus 로고
    • Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
    • DOI 10.1038/nchembio869, PII NCHEMBIO869
    • S. Bergmann, J. Schümann, K. Scherlach, C. Lange, A.A. Brakhage, and C. Hertweck Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans Nat. Chem. Biol. 3 2007 213 217 (Pubitemid 46440540)
    • (2007) Nature Chemical Biology , vol.3 , Issue.4 , pp. 213-217
    • Bergmann, S.1    Schumann, J.2    Scherlach, K.3    Lange, C.4    Brakhage, A.A.5    Hertweck, C.6
  • 5
    • 78650198931 scopus 로고    scopus 로고
    • Fungal secondary metabolites - Strategies to activate silent gene clusters
    • A.A. Brakhage, and V. Schroeckh Fungal secondary metabolites - strategies to activate silent gene clusters Fungal Genet. Biol. 48 2011 15 22
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 15-22
    • Brakhage, A.A.1    Schroeckh, V.2
  • 8
    • 55949136133 scopus 로고    scopus 로고
    • Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis
    • M. Brock, G. Jouvion, S. Droin-Bergere, O. Dussurget, M.A. Nicola, and O. Ibrahim-Granet Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis Appl. Environ. Microbiol. 74 2008 7023 7035
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 7023-7035
    • Brock, M.1    Jouvion, G.2    Droin-Bergere, S.3    Dussurget, O.4    Nicola, M.A.5    Ibrahim-Granet, O.6
  • 11
    • 68049088909 scopus 로고    scopus 로고
    • A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans
    • Y.M. Chiang, E. Szewczyk, A.D. Davidson, N. Keller, B.R. Oakley, and C.C. Wang A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans J. Am. Chem. Soc. 131 2009 2965 2970
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2965-2970
    • Chiang, Y.M.1    Szewczyk, E.2    Davidson, A.D.3    Keller, N.4    Oakley, B.R.5    Wang, C.C.6
  • 12
    • 73949102298 scopus 로고    scopus 로고
    • Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
    • R.H. Cichewicz Epigenome manipulation as a pathway to new natural product scaffolds and their congeners Nat. Prod. Rep. 27 2010 11 22
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 11-22
    • Cichewicz, R.H.1
  • 13
    • 0033924468 scopus 로고    scopus 로고
    • PH regulation of gene expression in fungi
    • DOI 10.1006/fgbi.2000.1188
    • S.H. Denison pH regulation of gene expression in fungi Fungal Genet. Biol. 29 2000 61 71 (Pubitemid 30440237)
    • (2000) Fungal Genetics and Biology , vol.29 , Issue.2 , pp. 61-71
    • Denison, S.H.1
  • 14
    • 0025944347 scopus 로고
    • Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans
    • C.E. Dowzer, and J.M. Kelly Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans Mol. Cell. Biol. 11 1991 5701 5709 (Pubitemid 21895337)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.11 , pp. 5701-5709
    • Dowzer, C.E.A.1    Kelly, J.M.2
  • 15
    • 33646575320 scopus 로고    scopus 로고
    • Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development
    • DOI 10.1016/j.fgb.2006.01.015, PII S1087184506000338
    • F. Ebel, M. Schwienbacher, J. Beyer, J. Heesemann, A.A. Brakhage, and M. Brock Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development Fungal Genet. Biol. 43 2006 476 489 (Pubitemid 43729189)
    • (2006) Fungal Genetics and Biology , vol.43 , Issue.7 , pp. 476-489
    • Ebel, F.1    Schwienbacher, M.2    Beyer, J.3    Heesemann, J.4    Brakhage, A.A.5    Brock, M.6
  • 16
    • 33947328945 scopus 로고    scopus 로고
    • Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana
    • DOI 10.1002/cbic.200600398
    • K.L. Eley, L.M. Halo, Z.S. Song, H. Powles, R.J. Cox, A.M. Bailey, C.M. Lazarus, and T.J. Simpson Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana Chembiochem. 8 2007 289 297 (Pubitemid 47194509)
    • (2007) ChemBioChem , vol.8 , Issue.3 , pp. 289-297
    • Eley, K.L.1    Halo, L.M.2    Song, Z.3    Powles, H.4    Cox, R.J.5    Bailey, A.M.6    Lazarus, C.M.7    Simpson, T.J.8
  • 18
    • 0015270398 scopus 로고
    • Flavipucine [3′-isovaleryl-6-methylpyridine-3-spiro-2′- oxiran-2(1H),-4(3H)-dione], an antibiotic from Aspergillus flavipes
    • J.A. Findlay, and L. Radics Flavipucine [3′-isovaleryl-6- methylpyridine-3-spiro-2′-oxiran-2(1H),-4(3H)-dione], an antibiotic from Aspergillus flavipes J. Chem. Soc. Perkin. 1 16 1972 2071 2074
    • (1972) J. Chem. Soc. Perkin. 1 , vol.16 , pp. 2071-2074
    • Findlay, J.A.1    Radics, L.2
  • 20
    • 77956795517 scopus 로고    scopus 로고
    • Aspergillus fumigatus catalytic glucokinase and hexokinase: Expression analysis and importance for germination, growth, and conidiation
    • C.B. Fleck, and M. Brock Aspergillus fumigatus catalytic glucokinase and hexokinase: expression analysis and importance for germination, growth, and conidiation Eukaryot. Cell 9 2010 1120 1135
    • (2010) Eukaryot. Cell , vol.9 , pp. 1120-1135
    • Fleck, C.B.1    Brock, M.2
  • 22
    • 67650308266 scopus 로고    scopus 로고
    • Hidden biosynthetic treasures brought to light
    • C. Hertweck Hidden biosynthetic treasures brought to light Nat. Chem. Biol. 5 2009 450 452
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 450-452
    • Hertweck, C.1
  • 23
    • 33947694781 scopus 로고    scopus 로고
    • Natural products of filamentous fungi: Enzymes, genes, and their regulation
    • DOI 10.1039/b603084j
    • D. Hoffmeister, and N.P. Keller Natural products of filamentous fungi: enzymes, genes, and their regulation Nat. Prod. Rep. 24 2007 393 416 (Pubitemid 46496563)
    • (2007) Natural Product Reports , vol.24 , Issue.2 , pp. 393-416
    • Hoffmeister, D.1    Keller, N.P.2
  • 24
    • 2442636663 scopus 로고    scopus 로고
    • CreA-mediated carbon catabolite repression of β-galactosidase formation in Aspergillus nidulans is growth rate dependent
    • DOI 10.1016/j.femsle.2004.04.020, PII S0378109704002794
    • H. Ilyés, E. Fekete, L. Karaffa, E. Fekete, E. Sandor, A. Szentirmai, and C.P. Kubicek CreA-mediated carbon catabolite repression of beta-galactosidase formation in Aspergillus nidulans is growth rate dependent FEMS Microbiol. Lett. 235 2004 147 151 (Pubitemid 38668649)
    • (2004) FEMS Microbiology Letters , vol.235 , Issue.1 , pp. 147-151
    • Ilyes, H.1    Fekete, E.2    Karaffa, L.3    Fekete, E.4    Sandor, E.5    Szentirmai, A.6    Kubicek, C.P.7
  • 25
    • 0026466149 scopus 로고
    • Determination of the base recognition positions of zinc fingers from sequence analysis
    • G.H. Jacobs Determination of the base recognition positions of zinc fingers from sequence analysis EMBO J. 11 1992 4507 4517
    • (1992) EMBO J. , vol.11 , pp. 4507-4517
    • Jacobs, G.H.1
  • 26
    • 0036396532 scopus 로고    scopus 로고
    • α-H···O hydrogen bonds and van der Waals interactions
    • DOI 10.1016/S0022-2836(02)00885-9
    • G. Kleiger, and D. Eisenberg GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H. O hydrogen bonds and van der waals interactions J. Mol. Biol. 323 2002 69 76 (Pubitemid 35168480)
    • (2002) Journal of Molecular Biology , vol.323 , Issue.1 , pp. 69-76
    • Kleiger, G.1    Eisenberg, D.2
  • 27
    • 77149179370 scopus 로고    scopus 로고
    • New tools for the genetic manipulation of filamentous fungi
    • U. Kück, and B. Hoff New tools for the genetic manipulation of filamentous fungi Appl. Microbiol. Biotechnol. 86 2010 51 62
    • (2010) Appl. Microbiol. Biotechnol. , vol.86 , pp. 51-62
    • Kück, U.1    Hoff, B.2
  • 28
    • 0019963691 scopus 로고
    • Aspergillus terreus, a pathogen capable of causing infective endocarditis, pulmonary mycetoma, and allergic bronchopulmonary aspergillosis
    • M.N. Laham, and J.L. Carpenter Aspergillus terreus, a pathogen capable of causing infective endocarditis, Pulmonary mycetoma, and allergic bronchopulmonary aspergillosis Am. Rev. Respir. Dis. 125 1982 769 772 (Pubitemid 12074599)
    • (1982) American Review of Respiratory Disease , vol.125 , Issue.6 , pp. 769-772
    • Laham, M.N.1    Carpenter, J.L.2
  • 30
    • 70149112335 scopus 로고    scopus 로고
    • Cyclopiazonic acid biosynthesis in Aspergillus sp.: Characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan
    • X. Liu, and C.T. Walsh Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan Biochemistry 48 2009 8746 8757
    • (2009) Biochemistry , vol.48 , pp. 8746-8757
    • Liu, X.1    Walsh, C.T.2
  • 31
    • 34948842874 scopus 로고    scopus 로고
    • Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus
    • DOI 10.1002/cbic.200700202
    • S. Maiya, A. Grundmann, X. Li, S.M. Li, and G. Turner Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus Chembiochem. 8 2007 1736 1743 (Pubitemid 47523678)
    • (2007) ChemBioChem , vol.8 , Issue.14 , pp. 1736-1743
    • Maiya, S.1    Grundmann, A.2    Li, X.3    Li, S.-M.4    Turner, G.5
  • 33
    • 0037323820 scopus 로고    scopus 로고
    • AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR
    • DOI 10.1046/j.1365-2958.2003.03326.x
    • M. Mihlan, V. Homann, T.W. Liu, and B. Tudzynski AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR Mol. Microbiol. 47 2003 975 991 (Pubitemid 36232795)
    • (2003) Molecular Microbiology , vol.47 , Issue.4 , pp. 975-991
    • Mihlan, M.1    Homann, V.2    Liu, T.-W.D.3    Tudzynski, B.4
  • 34
    • 68149139540 scopus 로고    scopus 로고
    • Fungal phytotoxins as mediators of virulence
    • N. Möbius, and C. Hertweck Fungal phytotoxins as mediators of virulence Curr. Opin. Plant Biol. 12 2009 390 398
    • (2009) Curr. Opin. Plant Biol. , vol.12 , pp. 390-398
    • Möbius, N.1    Hertweck, C.2
  • 35
    • 0032513214 scopus 로고    scopus 로고
    • The CreA repressor is the sole DNA-binding protein responsible for carbon catabolite repression of the alcA gene in Aspergillus nidulans via its binding to a couple of specific sites
    • DOI 10.1074/jbc.273.11.6367
    • C. Panozzo, E. Cornillot, and B. Felenbok The CreA repressor is the sole DNA-binding protein responsible for carbon catabolite repression of the alcA gene in Aspergillus nidulans via its binding to a couple of specific sites J. Biol. Chem. 273 1998 6367 6372 (Pubitemid 28144728)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.11 , pp. 6367-6372
    • Panozzo, C.1    Cornillot, E.2    Felenbok, B.3
  • 38
    • 0020502177 scopus 로고
    • Isolation and identification of fruit rot toxins from the fungus-caused Macrophoma fruit rot of the apple
    • T. Sassa, and Y. Onuma Isolation and identification of fruit rot toxins from the fungus-caused Macrophoma fruit rot of apple Agric. Biol. Chem. 47 1983 1155 1157 (Pubitemid 13010298)
    • (1983) Agricultural and Biological Chemistry , vol.47 , Issue.5 , pp. 1155-1157
    • Sassa, T.1    Onuma, Y.2
  • 39
    • 64549150542 scopus 로고    scopus 로고
    • Triggering cryptic natural product biosynthesis in microorganisms
    • K. Scherlach, and C. Hertweck Triggering cryptic natural product biosynthesis in microorganisms Org. Biomol. Chem. 7 2009 1753 1760
    • (2009) Org. Biomol. Chem. , vol.7 , pp. 1753-1760
    • Scherlach, K.1    Hertweck, C.2
  • 41
    • 33745969462 scopus 로고    scopus 로고
    • Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes
    • DOI 10.1016/j.jbiotec.2006.03.046, PII S0168165606003245
    • J. Schümann, and C. Hertweck Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes J. Biotechnol. 124 2006 690 703 (Pubitemid 44066598)
    • (2006) Journal of Biotechnology , vol.124 , Issue.4 , pp. 690-703
    • Schumann, J.1    Hertweck, C.2
  • 42
    • 34547817781 scopus 로고    scopus 로고
    • Molecular basis of cytochalasan biosynthesis in fungi: Gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing
    • DOI 10.1021/ja072884t
    • J. Schümann, and C. Hertweck Molecular basis of cytochalasan biosynthesis in fungi: gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing J. Am. Chem. Soc. 129 2007 9564 9565 (Pubitemid 47237448)
    • (2007) Journal of the American Chemical Society , vol.129 , Issue.31 , pp. 9564-9565
    • Schumann, J.1    Hertweck, C.2
  • 43
    • 50249158518 scopus 로고    scopus 로고
    • Thioesterase-like role for fungal PKS-NRPS hybrid reductive domains
    • J.W. Sims, and E.W. Schmidt Thioesterase-like role for fungal PKS-NRPS hybrid reductive domains J. Am. Chem. Soc. 130 2008 11149 11155
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 11149-11155
    • Sims, J.W.1    Schmidt, E.W.2
  • 45
    • 0031592466 scopus 로고    scopus 로고
    • Micro-scale extraction procedure for standardization screening of fungal metabolite production in cultures
    • DOI 10.1016/S0021-9673(96)00803-5, PII S0021967396008035
    • J. Smedsgaard Micro-scale extraction procedure for standardized screening of fungal metabolite production in cultures J. Chromatogr. A 760 1997 264 270 (Pubitemid 27085582)
    • (1997) Journal of Chromatography A , vol.760 , Issue.2 , pp. 264-270
    • Smedsgaard, J.1
  • 46
    • 4644244128 scopus 로고    scopus 로고
    • Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum
    • DOI 10.1002/cbic.200400138
    • Z. Song, R.J. Cox, C.M. Lazarus, and T.J. Simpson Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum Chembiochem. 5 2004 1196 1203 (Pubitemid 39297249)
    • (2004) ChemBioChem , vol.5 , Issue.9 , pp. 1196-1203
    • Song, Z.1    Cox, R.J.2    Lazarus, C.M.3    Simpson, T.J.4
  • 47
    • 43049168768 scopus 로고    scopus 로고
    • CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans
    • E.N. Tamayo, A. Villanueva, A.A. Hasper, L.H. de Graaff, D. Ramon, and M. Orejas CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans Fungal Genet. Biol. 45 2008 984 993
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 984-993
    • Tamayo, E.N.1    Villanueva, A.2    Hasper, A.A.3    De Graaff, L.H.4    Ramon, D.5    Orejas, M.6
  • 48
    • 0028913388 scopus 로고
    • The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH
    • J. Tilburn, S. Sarkar, D.A. Widdick, E.A. Espeso, M. Orejas, J. Mungroo, M.A. Penalva, and H.N. Arst Jr. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH EMBO J. 14 1995 779 790
    • (1995) EMBO J. , vol.14 , pp. 779-790
    • Tilburn, J.1    Sarkar, S.2    Widdick, D.A.3    Espeso, E.A.4    Orejas, M.5    Mungroo, J.6    Penalva, M.A.7    Arst Jr., H.N.8
  • 49
    • 56049119614 scopus 로고    scopus 로고
    • Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae
    • M. Tokuoka, Y. Seshime, I. Fujii, K. Kitamoto, T. Takahashi, and Y. Koyama Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae Fungal Genet. Biol. 45 2008 1608 1615
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 1608-1615
    • Tokuoka, M.1    Seshime, Y.2    Fujii, I.3    Kitamoto, K.4    Takahashi, T.5    Koyama, Y.6
  • 51
    • 0031978491 scopus 로고    scopus 로고
    • Rubrobramide, a cytotoxic and phytotoxic metabolite from Cladobotryum rubrobrunnescens
    • DOI 10.1021/np9704967
    • C. Wagner, H. Anke, and O. Sterner Rubrobramide, a cytotoxic and phytotoxic metabolite from Cladobotryum rubrobrunnescens J. Nat. Prod. 61 1998 501 502 (Pubitemid 28217515)
    • (1998) Journal of Natural Products , vol.61 , Issue.4 , pp. 501-502
    • Wagner, C.1    Anke, H.2    Sterner, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.