Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells

Molecular and Cellular Neuroscience

Volumn 46, Issue 3, 2011, Pages 655-661

  Kim, Euysoo ^a   Hyrc, Krzysztof L ^a   Speck, Judith ^a   Salles, Felipe T ^b   Lundberg, Yunxia W ^c   Goldberg, Mark P ^d   Kachar, Bechara ^b   Warchol, Mark E ^a   Ornitz, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^c BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Calcium; Otoconia; Otopetrin; Purinergic signaling; Vestibular

Indexed keywords

MUTANT PROTEIN; PURINERGIC P2Y RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; GENE; GENE LOCATION; MISSENSE MUTATION; MOUSE; NEUROEPITHELIUM; NONHUMAN; NULL ALLELE; OTOLITH; OTOPETRIN 1 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; EPITHELIAL CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MUTATION, MISSENSE; OTOLITHIC MEMBRANE; RECEPTORS, PURINERGIC P2Y; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; VESTIBULE, LABYRINTH;

MUS;

EID: 79951852316     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2011.01.005     Document Type: Article

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