The real mechanism of VPA-induced hyperammonemia remains unknown

General Hospital Psychiatry

Volumn 33, Issue 1, 2011, Pages 84.e3-84.e4

  Hung, Chung Chieh ^a   Li, Tin May ^a   Wei, I Hua ^b   Huang, Chih Chia ^a,b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Early recognition; Hyperammonemia; Risk factors; Valproic acid

Indexed keywords

AMISULPRIDE; AMMONIA; ARIPIPRAZOLE; CLONAZEPAM; LACTULOSE; RISPERIDONE; VALPROIC ACID;

ADJUVANT THERAPY; ADULT; AGGRESSION; AMENORRHEA; AMMONIA BLOOD LEVEL; ARTICLE; ATAXIA; AUDITORY HALLUCINATION; BEHAVIOR DISORDER; CASE REPORT; CLINICAL FEATURE; DISEASE EXACERBATION; DROWSINESS; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; FEMALE; FLUID THERAPY; HUMAN; HYPERAMMONEMIA; MANIA; MOOD DISORDER; NAUSEA; NUTRITIONAL DEFICIENCY; PROTEIN INTAKE; SCHIZOAFFECTIVE PSYCHOSIS; TREATMENT DURATION; VOMITING;

EID: 79951850163     PISSN: 01638343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2010.10.004     Document Type: Article

References (10)

1. Carr R.B., Shrewsbury K. Hyperammonemia due to valproic acid in the psychiatric setting. Am J Psychiatry 2007, 164:1020-1027.
2. Dealberto M.J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. Int Clin Psychopharmacol 2007, 22:330-337.
3. Huang Y.T., Chien Y., Yeh H.Y., Lin S.J., Lu F.L., Chou S.P., et al. Phenotype and genotype analyses of ornithine transcarbamylase deficiency in Taiwanese. J Formos Med Assoc 2003, 102:851-856.
4. Raskind J.Y., El-Chaar G.M. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 2000, 34:630-638.
5. Nicolai J., Smith S.J., Keunen R.W. Simultaneous side effects of both clozapine and valproate. Intensive Care Med 2001, 27:943.
6. Shan J.C., Hsieh M.H., Liu C.C., Wen C.C., Liu C.M. Clinical alertness to valproic acid-induced hyperammonemia-two case reports. J Psychopharmacol 2010, 24:943-945.
7. Hamed S.A., Abdella M.M. The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. Epilepsy Res 2009, 86:32-41.
8. Laub M.C. Hyperammonemia in valproate therapy in children and adolescents. Nervenarzt 1986, 57:314-318.
9. Verrotti A., Greco R., Morgese G., Chiarelli F. Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. Int J Clin Lab Res 1999, 29:36-40.
10. Shapiro Y.G., Gutman A. Muscle carnitine deficiency in patients using valproic acid. J Pediatr 1991, 118:646-649.