Influence of internal fixator stiffness on murine fracture healing: Two types of fracture healing lead to two distinct cellular events and FGF-2 expressions

Experimental Animals

Volumn 60, Issue 1, 2011, Pages 79-87

  Ueno, Masaki ^a   Urabe, Ken ^a   Naruse, Kouji ^a   Uchida, Kentaroo ^a   Minehara, Hiroaki ^a   Yamamoto, Takeaki ^a   Steck, Roland ^b   Gregory, Laura ^b   Wullschleger, Martin E ^b,c   Schuetz, Michael A ^b,c   Itoman, Moritoshi ^d  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c PRINCESS ALEXANDRA HOSPITAL   (Australia)

^d KYUSHU ROSAI HOSPITAL   (Japan)

Author keywords

Callus formation; Fracture; Growth factor; Internal fixator; Mouse

Indexed keywords

CYCLINE; FIBROBLAST GROWTH FACTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALLUS; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; FEMUR FRACTURE; FIBROBLAST; FRACTURE HEALING; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; INTERNAL FIXATOR; MALE; MECHANICAL STRESS; MOUSE; NONHUMAN; PLATE FIXATION; PROTEIN EXPRESSION;

ANIMALS; BONY CALLUS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; FRACTURE HEALING; INTERNAL FIXATORS; MICE; PROLIFERATING CELL NUCLEAR ANTIGEN; STRESS, MECHANICAL;

MURINAE; MUS;

EID: 79951838468     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.60.79     Document Type: Article

References (30)

1. Barnes, G.L., Kostenuik, P.J., Gerstenfeld, L.C., and Einhorn, T.A. 1999. Growth factor regulation of fracture repair. J. Bone Miner. Res. 14: 1805-1815.
2. Bolander, M.E. 1992. Regulation of fracture repair by growth factors. Proc. Soc. Exp. Biol. Med. 200: 165-170.
3. Canalis, E.,Centrella, M., and McCarthy,T. 1988. Effects of basic fibroblast growth factor on bone formation in vitro. J. Clin. Invest. 81: 1572-1577.
4. Canalis, E., McCarthy, T., and Centrella. M. 1988. Growth factors and the regulation of bone remodeling. J. Clin. Invest. 81: 277-281.
5. Canalis, E., McCarthy, T.L., and Centrella, M. 1991. Growth factors and cytokines in bone cell metabolism. Annu. Rev. Med. 42: 17-24.
6. Chao, E.Y., Aro, H.T., Lewallen, D.G., and Kelly, P.J. 1989. The effect of rigidity on fracture healing in external fixation. Clin. Orthop. Relat. Res. 241: 24-35.
7. Cillo, J.E. Jr., Gassner, R., Koepsel, R.R., and Buckley, M.J. 2000. Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 90: 147-154.
8. Claes, L.E. and Heigele, C.A. 1999. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J. Biomech. 32: 255-266.
9. Einhorn, T.A. 1998. The cell and molecular biology of fracture healing. Clin. Orthop. Relat. Res. 355: S7-21.
10. Grongroft, I., Heil, P., Matthys, R., Lezuo, P., Tami, A., Perren, S., Montavon, P., and Ito, K. 2009. Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union. J. Biomech. 42: 2089-2096.
11. Hurley, M.M., Kessler, M., Gronowicz, G., and Raisz, L.G. 1992. The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae. Endocrinology 130: 2675-2682.
12. Jingushi, S., Heydemann, A., Kana, S.K., Macey, L.R., and Bolander, M.E. 1990. Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing. J. Orthop. Res. 8: 364-371.
13. Kato, T., Kawaguchi, H., Hanada, K., Aoyama, I., Hiyama, Y., Nakamura, T., Kuzutani, K., Tamura, M., Kurokawa, T., and Nakamura, K. 1998. Single local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits. J. Orthop. Res. 16: 654-659.
14. Kawaguchi, H., Kurokawa, T., Hanada, K., Hiyama, Y., Tamura, M., Ogata, E., and Matsumoto, T. 1994. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology 135: 774-781.
15. Kawaguchi, H., Nakamura, K., Tabata, Y., Ikada, Y., Aoyama, I., Anzai, J., Nakamura, T., Hiyama, Y., and Tamura, M. 2001. Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2. J. Clin. Endocrinol. Metab. 875-880.
16. Kawaguchi, H., Oka, H., Jingushi, S., Izumi, T., Fukunaga, M., Sato, K., Matsushita, T., and Nakamura, K. 2010. A local application of recombinant human fibroblast growth factor-2 for tibial shaft fractures: a randomized, placebo-controlled trial. J. Bone Miner. Res. (in press).
17. Li, C.F. and Hughes-Fulford, M. 2006. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J. Bone Miner. Res. 21: 946-955.
18. Matthys, R. and Perren, S.M. 2009. Internal fixator for use in the mouse. Injury 40: S103-109.
19. Mayahara, H., Ito, T., Nagai, H., Miyajima, H., Tsukuda, R., Taketomi, S., Mizoguchi, J., and Kato, K. 1993. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Factors 9: 73-80.
20. McCarthy, T.L., Centrella, M., and Canalis, E. 1989. Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. Endocrinology 125: 2118-2126.
21. Nakamura, K., Kawaguchi, H., Aoyama, I., Hanada, K., Hiyama, Y., Awa, T., Tamura, M., and Kurokawa, T. 1997. Stimulation of bone formation by intraosseous application of recombinant basic fibroblast growth factor in normal and ovariectomized rabbits. J. Orthop. Res. 15: 307-313.
22. Nakamura, T., Hara, Y., Tagawa, M., Tamura, M., Yuge, T., Fukuda, H., and Nigi, H. 1998. Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture. J. Bone Miner. Res. 13: 942-949.
23. Olerud, S. and Danckwardt-Lilliestrom, G. 1968. Fracture healing in compression osteosynthesis in the dog. J. Bone Joint Surg. Br. 50: 844-851.
24. Otto, T.E., Patka, P., and Haarman, H.J. 1995. Closed fracture healing: a rat model. Eur. Surg. Res. 27: 277-284.
25. Perren, S.M. 2008. Fracture healing. The evolution of our understanding. Acta Chir. Orthop. Traumatol. Cech. 75: 241-246.
26. Perren, S.M., Huggler, A., Russenberger, M., Allgower, M., Mathys, R., Schenk, R., Willenegger, H., and Muller, M.E. 1969. The reaction of cortical bone to compression. Acta Orthop. Scand. Suppl. 125: 19-29
27. Radomsky, M.L., Aufdemorte, T.B., Swain, L.D., Fox, W.C., Spiro, R.C., and Poser, J.W. 1999. Novel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in nonhuman primates. J. Orthop. Res. 17: 607-614.
28. Rodan, S.B., Wesolowski, G., Yoon, K., and Rodan, G.A. 1989. Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells. J. Biol. Chem. 264: 19934-19941.
29. Tabata, Y., Yamada, K., Hong, L., Miyamoto, S., Hashimoto, N., and Ikada, Y. 1999. Skull bone regeneration in primates in response to basic fibroblast growth factor. J. Neurosurg. 91: 851-856.
30. Yeung, H.Y., Lee, S.K., Fung, K.P., and Leung, K.S. 2001. Expression of basic fibroblast growth factor during distraction osteogenesis. Clin. Orthop. Relat. Res. 219-229.