Delivery of a therapeutic protein by immune-privileged sertoli cells

Cell Transplantation

Volumn 19, Issue 12, 2010, Pages 1645-1657

  Halley, Katelyn ^a   Dyson, Emily L ^a   Kaur, Gurvinder ^a   Mital, Payal ^a   Uong, Peter M ^a   Dass, Brinda ^a   Crowell, Sherry N ^a   Dufour, Jannette M ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Gene therapy; Insulin; Sertoli cell; Transplantation

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; FURIN; INSULIN; MESSENGER RNA; PROINSULIN;

ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL THERAPY; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC TRANSDUCTION; GLUCOSE BLOOD LEVEL; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SERTOLI CELL; THERAPY EFFECT;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; GENE THERAPY; HUMANS; INSULIN; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; SERTOLI CELLS; SWINE;

MUS; SUS;

EID: 79951836218     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X516628     Document Type: Article

References (33)

1. Barry, S. C.; Ramesh, N.; Lejnieks, D.; Simonson, W. T.; Kemper, L.; Lernmark, A.; Osborne, W. R. Glucose-regulated insulin expression in diabetic rats. Hum. Gene Ther. 12(2):131-139; 2001.
2. Bellgrau, D.; Gold, D.; Selawry, H.; Moore, J.; Franzusoff, A.; Duke, R. C. A role for CD95 ligand in preventing graft rejection. Nature 377(6550):630-632; 1995.
3. Davidson, H. W. (Pro)Insulin processing: A historical perspective. Cell Biochem. Biophys. 40(3 Suppl.):143-158;2004.
4. Dong, H.; Altomonte, J.; Morral, N.; Meseck, M.; Thung, S. N.; Woo, S. L. Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 51(1):130-138; 2002.
5. Dufour, J. M.; Dass, B.; Halley, K. R.; Korbutt, G. S.; Dixon, D. E.; Rajotte, R. V. Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells. Cell Transplant. 17(5):525-534; 2008.
6. Dufour, J. M.; Hamilton, M.; Rajotte, R. V.; Korbutt, G. S. Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis. Biol. Reprod. 72(5):1224-1231; 2005.
7. Dufour, J. M.; Hemendinger, R.; Halberstadt, C. R.; Gores, P.; Emerich, D. F.; Korbutt, G. S.; Rajotte, R. V. Genetically engineered Sertoli cells are able to survive allogeneic transplantation. Gene Ther. 11(8):694-700; 2004.
8. Dufour, J. M.; Lord, S. J.; Kin, T.; Rayat, G. R.; Dixon, D. E.; Bleackley, R. C.; Korbutt, G. S.; Rajotte, R. V. Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice. Cell Transplant. 16(10):1029-1038; 2008.
9. Dufour, J. M.; Rajotte, R. V.; Seeberger, K.; Kin, T.; Korbutt, G. S. Long-term survival of neonatal porcine Sertoli cells in non-immunosuppressed rats. Xenotransplantation 10(6):577-586; 2003.
10. Dufrane, D.; Gianello, P. Pig islet xenotransplantation into non-human primate model. Transplantation 86(6):753-760; 2008.
11. Fijak, M.; Meinhardt, A. The testis in immune privilege. Immunol. Rev. 213:66-81; 2006.
12. Gores, P. F.; Hayes, D. H.; Copeland, M. J.; Korbutt, G. S.; Halberstadt, C.; Kirkpatrick, S. A.; Rajotte, R. V. Long-term survival of intratesticular porcine islets in non-immunosuppressed beagles. Transplantation 75(5):613-618; 2003.
13. Griswold, M. D. The central role of Sertoli cells in spermatogenesis. Semin. Cell Dev. Biol. 9(4):411-416; 1998.
14. Groskreutz, D. J.; Sliwkowski, M. X.; Gorman, C. M. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J. Biol. Chem. 269(8):6241-6245; 1994.
15. Hilgert, I.; Stolba, P.; Kristofova, H.; Stefanova, I.; Bendlova, B.; Lebl, M.; Horejsi, V. A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA. Hybridoma 10(3):379-386; 1991.
16. Huang, X.; Moore, D. J.; Ketchum, R. J.; Nunemaker, C. S.; Kovatchev, B.; McCall, A. L.; Brayman, K. L. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr. Rev. 29(5):603-630; 2008.
17. Ikeda, M.; Kodama, H.; Fukuda, J.; Shimizu, Y.; Murata, M.; Kumagai, J.; Tanaka, T. Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biol. Reprod. 61(2):393-399; 1999.
18. Korbutt, G. S.; Elliott, J. F.; Rajotte, R. V. Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression. Diabetes 46(2):317-322; 1997.
19. Martinenghi, S.; Cusella De Angelis, G.; Biressi, S.; Amadio, S.; Bifari, F.; Roncarolo, M. G.; Bordignon, C.; Falqui, L. Human insulin production and amelioration of diabetes in mice by electrotransfer-enhanced plasmid DNA gene transfer to the skeletal muscle. Gene Ther. 9(21):1429-1437; 2002.
20. Mital, P.; Kaur, G.; Dufour, J. M. Immunoprotective sertoli cells: making allogeneic and xenogeneic transplantation feasible. Reproduction 139(3):495-504; 2010.
21. Pepper, A. R.; Gall, C.; Mazzuca, D. M.; Melling, C. W.; White, D. J. Diabetic rats and mice are resistant to porcine and human insulin: Flawed experimental models for testing islet xenografts. Xenotransplantation 16(6):502-510; 2009.
22. Romano, G.; Michell, P.; Pacilio, C.; Giordano, A. Latest developments in gene transfer technology: Achievements, perspectives, and controversies over therapeutic applications. Stem Cells 18(1):19-39; 2000.
23. Saporta, S.; Cameron, D. F.; Borlongan, C. V.; Sanberg, P. R. Survival of rat and porcine Sertoli cell transplants in the rat striatum without cyclosporine-A immunosuppression. Exp. Neurol. 146(2):299-304; 1997.
24. Shifrin, A. L.; Auricchio, A.; Yu, Q. C.; Wilson, J.; Raper, S. E. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther. 8(19):1480-1489; 2001.
25. Sipione, S.; Simmen, K. C.; Lord, S. J.; Motyka, B.; Ewen, C.; Shostak, I.; Rayat, G. R.; Dufour, J. M.; Korbutt, G. S.; Rajotte, R. V.; Bleackley, R. C. Identification of a novel human granzyme B inhibitor secreted by cultured Sertoli cells. J. Immunol. 177(8):5051-5058; 2006.
26. Somia, N.; Verma, I. M. Gene therapy: Trials and tribulations. Nat. Rev. Genet. 1(2):91-99; 2000.
27. Thomas, C. E.; Ehrhardt, A.; Kay, M. A. Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4(5):346-358; 2003.
28. Thomas, G. Furin at the cutting edge: From protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3(10):753-766; 2002.
29. Thule, P. M.; Liu, J.; Phillips, L. S. Glucose regulated production of human insulin in rat hepatocytes. Gene Ther. 7(3):205-214; 2000.
30. Trivedi, A. A.; Igarashi, T.; Compagnone, N.; Fan, X.; Hsu, J. Y.; Hall, D. E.; John, C. M.; Noble-Haeusslein, L. J. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp. Neurol. 198(1):88-100; 2006.
31. Wennberg, L.; Song, Z.; Bennet, W.; Zhang, J.; Nava, S.; Sundberg, B.; Bari, S.; Groth, C. G.; Korsgren, O. Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days. Transplantation 71(8):1024-1033; 2001.
32. Won, J. C.; Rhee, B. D.; Ko, K. S. Glucose-responsive gene expression system for gene therapy. Adv. Drug Deliv. Rev. 61(7-8):633-640; 2009.
33. Xu, R.; Li, H.; Tse, L. Y.; Kung, H. F.; Lu, H.; Lam, K. S. Diabetes gene therapy: Potential and challenges. Curr. Gene Ther. 3(1):65-82; 2003.