Effects of fosinopril and losartan on renal Klotho expression and oxidative stress in spontaneously hypertensive rats

Journal of Central South University (Medical Sciences)

Volumn 36, Issue 1, 2011, Pages 27-33

  Tang, Rong ^a   Zhou, Qiaoling ^a   Liu, Zhichun ^a   Xiao, Zhou ^a   Pouranan, Veeraragoo ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Fosinopril; Hypertensive renal damage; Klotho; Losartan; Oxidative stress

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA GLUCURONIDASE; FOSINOPRIL; KLOTHO PROTEIN; LOSARTAN; MESSENGER RNA;

ANIMAL; ARTICLE; DRUG EFFECT; GENETICS; HYPERTENSION; KIDNEY; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; FOSINOPRIL; GLUCURONIDASE; HYPERTENSION; KIDNEY; LOSARTAN; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RNA, MESSENGER;

EID: 79951830396     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2011.01.005     Document Type: Article

References (16)

1. Yen P L, Chen B H, Yang F L, et al. Effects of deepfrying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats [J]. Nutrition, 2010, 26(3): 331-336.
2. Kuro - o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing [J]. Nature, 1997, 390(6655): 45-51.
3. Kuro-o M. Klotho [J]. Pflugers Arch, 2010, 459 (2): 333-343.
4. Cheng M F, Chen L J, Cheng J T. Decrease of klotho in the kidney of streptozotocin - induced diabetic rats [J]. J Biomed Biotechnol, 2010, 2010:: 513853.
5. Wang Y, Sun Z. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage [J]. Hypertension , 2009, 54(4): 810-817.
6. ZOU Hequn. Pay attention to the early intervention of hypertensive renal damage [J]. Chinese Journal of Nephrology, 2005, 21(10): 575-576.
7. Ruilope L M. The kidney as a sensor of cardiovascular risk in essential hypertension [J]. J Am Soc Nephrol, 2002, 13(3): S165-168.
8. Hou X, Shen YH, Li C, et al. PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity [J]. Biochem Biophys Res Commun, 2010, 394(3): 653-659.
9. Haruna Y, Kashihara N, Satoh M, et al. Amelioration of progressive renal injury by genetic manipulation of Klotho gene [J]. Proc Nad Acad Sci USA, 2007, 104: 2331-2336. (Pubitemid 46391397)
10. Sugiura H, Yoshida T, Mitobe M , et al. Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70 [J]. Nephrol Dial Transplant, 2010, 25 (1): 60-68.
11. Kuro - o M. Klotho as a regulator of oxidative stress and senescence [J]. Biol Chem, 2008, 389(3): 233-241.
12. Zhang H, Li Y, Fan Y, et al. Klotho is a target gene of PPAR-γ [J]. Kidney International, 2008 , 74 (6): 732-739.
13. Li S A, Watanabe M, Yamada H, et al. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice [J]. Cell Struct Funct, 2004, 29(4): 91-99. (Pubitemid 40260033)
14. Hou X , Shen Y H, Li C, et al. PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity [J]. Biochem Biophys Res Commun, 2010, 394(3): 653-659.
15. Lopez - Ruiz AF, Iliescu R, Reckelhoff J F. Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes [J]. Am J Physiol Regul Integr Comp Physiol, 2010 , 298 (2): 266-271.
16. Shoda J, Kanno Y, Suzuki H, et al. A five - year comparison of the renal protective effects of angiotensin - converting enzyme inhibitors and angiotensin receptor blockers in patients with non - diabetic nephropathy [J]- Intern Med, 2006, 45(4): 193-198.