메뉴 건너뛰기




Volumn 178, Issue 2, 2011, Pages 924-934

IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; APOLIPOPROTEIN E; COLLAGEN TYPE 3; COLLAGEN TYPE 3A1; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 79951824369     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.10.007     Document Type: Article
Times cited : (72)

References (50)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P: Inflammation in atherosclerosis. Nature 2002, 420:868-874
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 2
    • 33745946145 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis: Novel insights into plaque formation and destabilization
    • DOI 10.1161/01.STR.0000226901.34927.10, PII 0000767020060700000068
    • Stoll G, Bendszus M: Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke 2006, 37:1923-1932 (Pubitemid 44297753)
    • (2006) Stroke , vol.37 , Issue.7 , pp. 1923-1932
    • Stoll, G.1    Bendszus, M.2
  • 3
    • 31344469271 scopus 로고    scopus 로고
    • Atherosclerosis and proteinase activation
    • DOI 10.1016/j.cardiores.2005.11.003, PII S000863630500516X
    • Dollery CM, Libby P. Atherosclerosis and proteinase activation. Cardiovasc Res 2006, 69:625-635 (Pubitemid 43139725)
    • (2006) Cardiovascular Research , vol.69 , Issue.3 , pp. 625-635
    • Dollery, C.M.1    Libby, P.2
  • 4
    • 0142061597 scopus 로고    scopus 로고
    • Apoptotic cell death in atherosclerosis
    • DOI 10.1097/00041433-200310000-00007
    • Littlewood TD, Bennett MR. Apoptotic cell death in atherosclerosis. Curr Opin Lipidol 2003, 14:469-475 (Pubitemid 37297301)
    • (2003) Current Opinion in Lipidology , vol.14 , Issue.5 , pp. 469-475
    • Littlewood, T.D.1    Bennett, M.R.2
  • 5
    • 33846416903 scopus 로고    scopus 로고
    • The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability
    • DOI 10.1159/000097815
    • Clarke M, Bennett M. The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability. Am J Nephrol 2006, 26:531-535 (Pubitemid 46143874)
    • (2006) American Journal of Nephrology , vol.26 , Issue.6 , pp. 531-535
    • Clarke, M.1    Bennett, M.2
  • 6
    • 33748469506 scopus 로고    scopus 로고
    • Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
    • DOI 10.1038/nm1459, PII NM1459
    • Clarke MC, Figg N, Maguire JJ, Davenport AP, Goddard M, Littlewood TD, Bennett MR: Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med 2006, 12:1075-1080 (Pubitemid 44353389)
    • (2006) Nature Medicine , vol.12 , Issue.9 , pp. 1075-1080
    • Clarke, M.C.H.1    Figg, N.2    Maguire, J.J.3    Davenport, A.P.4    Goddard, M.5    Littlewood, T.D.6    Bennett, M.R.7
  • 7
    • 0037197723 scopus 로고    scopus 로고
    • -/- mice after adenovirus-mediated transfer of p53
    • DOI 10.1161/01.CIR.0000015502.97828.93
    • von der Thusen JH, van Vlijmen BJ, Hoeben RC, Kockx MM, Havekes LM, van Berkel TJ, Biessen EA. Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation 2002, 105:2064-2070 (Pubitemid 34465269)
    • (2002) Circulation , vol.105 , Issue.17 , pp. 2064-2070
    • Von, D.T.J.H.1    Van, V.B.J.M.2    Hoeben, R.C.3    Kockx, M.M.4    Havekes, L.M.5    Van, B.T.J.C.6    Biessen, E.A.L.7
  • 9
    • 0033951649 scopus 로고    scopus 로고
    • The insulin-like growth factor axis: A review of atherosclerosis and restenosis
    • Bayes-Genis A, Conover CA, Schwartz RS: The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 2000, 86:125-130 (Pubitemid 30086171)
    • (2000) Circulation Research , vol.86 , Issue.2 , pp. 125-130
    • Bayes-Genis, A.1    Conover, C.A.2    Schwartz, R.S.3
  • 11
    • 1542344006 scopus 로고    scopus 로고
    • Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
    • Delafontaine P, Song YH, Li Y: Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels Arterioscler Thromb Vasc Biol 2004, 24:435-444
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 435-444
    • Delafontaine, P.1    Song, Y.H.2    Li, Y.3
  • 13
    • 25644435032 scopus 로고    scopus 로고
    • IGF-I concentrations are positively associated with carotid artery atherosclerosis in women
    • DOI 10.1080/07853890510011967
    • Hietaniemi M, Poykko SM, Ukkola O, Paivansalo M, Antero Kesaniemi Y: IGF-I concentrations are positively associated with carotid artery atherosclerosis in women. Ann Med 2005, 37:373-382 (Pubitemid 41379844)
    • (2005) Annals of Medicine , vol.37 , Issue.5 , pp. 373-382
    • Hietaniemi, M.1    Poykko, S.M.2    Ukkola, O.3    Paivansalo, M.4    Kesaniemi, Y.A.5
  • 14
    • 0037143639 scopus 로고    scopus 로고
    • Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: A population-based case-control study
    • DOI 10.1161/01.CIR.0000027563.44593.CC
    • Juul A, Scheike T, Davidsen M, Gyllenborg J, Jorgensen T: Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation 2002, 106:939-944 (Pubitemid 34925327)
    • (2002) Circulation , vol.106 , Issue.8 , pp. 939-944
    • Juul, A.1    Scheike, T.2    Davidsen, M.3    Gyllenborg, J.4    Jorgensen, T.5
  • 16
    • 0034781425 scopus 로고    scopus 로고
    • Decreased expression of insulin-like growth factor-1 and apoptosis of vascular smooth muscle cells in human atherosclerotic plaque
    • DOI 10.1006/jmcc.2001.1441
    • Okura Y, Brink M, Zahid AA, Anwar A, Delafontaine P: Decreased expression of insulin-like growth factor-1 and apoptosis of vascular smooth muscle cells in human atherosclerotic plaque. J Mol Cell Cardiol 2001, 33:1777-1789 (Pubitemid 32977132)
    • (2001) Journal of Molecular and Cellular Cardiology , vol.33 , Issue.10 , pp. 1777-1789
    • Okura, Y.1    Brink, M.2    Zahid, A.A.3    Anwar, A.4    Delafontaine, P.5
  • 17
    • 0035843913 scopus 로고    scopus 로고
    • Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling
    • Patel VA, Zhang QJ, Siddle K, Soos MA, Goddard M, Weissberg PL, Bennett MR: Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling. Circ Res 2001, 88:895-902 (Pubitemid 32441467)
    • (2001) Circulation Research , vol.88 , Issue.9 , pp. 895-902
    • Patel, V.A.1    Zhang, Q.-J.2    Siddle, K.3    Soos, M.A.4    Goddard, M.5    Weissberg, P.L.6    Bennett, M.R.7
  • 19
    • 0042163205 scopus 로고    scopus 로고
    • Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes
    • 't Hoen PA, Van der Lans CA, Van Eck M, Bijsterbosch MK, Van Berkel TJ, Twisk J: Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes. Circ Res 2003, 93:262-269
    • (2003) Circ Res , vol.93 , pp. 262-269
    • 'T Hoen, P.A.1    Van Der Lans, C.A.2    Van Eck, M.3    Bijsterbosch, M.K.4    Van Berkel, T.J.5    Twisk, J.6
  • 20
    • 0035957021 scopus 로고    scopus 로고
    • Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    • von der Thusen JH, van Berkel TJ, Biessen EA: Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Circulation 2001, 103:1164-1170
    • (2001) Circulation , vol.103 , pp. 1164-1170
    • Von Der Thusen, J.H.1    Van Berkel, T.J.2    Biessen, E.A.3
  • 21
    • 0029392515 scopus 로고
    • The insulin-like growth factor system in vascular smooth muscle: Interaction with insulin and growth factors
    • Arnqvist HJ, Bornfeldt KE, Chen Y, Lindstrom T: The insulin-like growth factor system in vascular smooth muscle: interaction with insulin and growth factors. Metabolism 1995, 44:58-66
    • (1995) Metabolism , vol.44 , pp. 58-66
    • Arnqvist, H.J.1    Bornfeldt, K.E.2    Chen, Y.3    Lindstrom, T.4
  • 22
    • 0033525072 scopus 로고    scopus 로고
    • Distinct and common pathways in the regulation of insulin-like growth factor-1 receptor gene expression by angiotensin II and basic fibroblast growth factor
    • DOI 10.1074/jbc.274.6.3522
    • Scheidegger KJ, Du J, Delafontaine P: Distinct and common pathways in the regulation of insulin-like growth factor-1 receptor gene expression by angiotensin II and basic fibroblast growth factor. J Biol Chem 1999, 274:3522-3530 (Pubitemid 29077193)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.6 , pp. 3522-3530
    • Scheidegger, K.J.1    Du, J.2    Delafontaine, P.3
  • 23
    • 0030034469 scopus 로고    scopus 로고
    • G-protein coupled and tyrosine kinase receptors: Evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells
    • Delafontaine P, Anwar A, Lou H, Ku L: G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells. J Clin Invest 1996, 97:139-145
    • (1996) J Clin Invest , vol.97 , pp. 139-145
    • Delafontaine, P.1    Anwar, A.2    Lou, H.3    Ku, L.4
  • 24
    • 0035947741 scopus 로고    scopus 로고
    • Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle characterization of the signaling pathway
    • Du J, Brink M, Peng T, Mottironi B, Delafontaine P: Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle: characterization of the signaling pathway. Circ Res 2001, 88:1044-1052 (Pubitemid 34137117)
    • (2001) Circulation Research , vol.88 , Issue.10 , pp. 1044-1052
    • Du, J.1    Brink, M.2    Peng, T.3    Mottironi, B.4    Delafontaine, P.5
  • 25
    • 0034282655 scopus 로고    scopus 로고
    • Differential effects of low density lipoproteins on insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells
    • Scheidegger KJ, James RW, Delafontaine P: Differential effects of low density lipoproteins on insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells. J Biol Chem 2000, 275:26864-26869
    • (2000) J Biol Chem , vol.275 , pp. 26864-26869
    • Scheidegger, K.J.1    James, R.W.2    Delafontaine, P.3
  • 26
    • 24944450780 scopus 로고    scopus 로고
    • A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor
    • DOI 10.1194/jlr.M400478-JLR200
    • Higashi Y, Peng T, Du J, Sukhanov S, Li Y, Itabe H, Parthasarathy S, Delafontaine P: A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor. J Lipid Res 2005, 46:1266-1277 (Pubitemid 43109841)
    • (2005) Journal of Lipid Research , vol.46 , Issue.6 , pp. 1266-1277
    • Higashi, Y.1    Peng, T.2    Du, J.3    Sukhanov, S.4    Li, Y.5    Itabe, H.6    Parthasarathy, S.7    Delafontaine, P.8
  • 27
    • 0348014420 scopus 로고    scopus 로고
    • Insulin-Like Growth Factor-1 Receptor Activation Inhibits Oxidized LDL-Induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway
    • DOI 10.1161/01.ATV.0000099788.31333.DB
    • Li Y, Higashi Y, Itabe H, Song YH, Du J, Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol 2003, 23:2178-2184 (Pubitemid 37532317)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.12 , pp. 2178-2184
    • Li, Y.1    Higashi, Y.2    Itabe, H.3    Song, Y.-H.4    Du, J.5    Delafontaine, P.6
  • 31
    • 0024573591 scopus 로고
    • Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells
    • DOI 10.1016/0006-291X(89)91667-7
    • Badesch DB, Lee PD, Parks WC, Stenmark KR: Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells. Biochem Biophys Res Commun 1989, 160:382-387 (Pubitemid 19116508)
    • (1989) Biochemical and Biophysical Research Communications , vol.160 , Issue.1 , pp. 382-387
    • Badesch, D.B.1    Lee, P.D.K.2    Parks, W.C.3    Stenmark, K.R.4
  • 32
    • 0037066049 scopus 로고    scopus 로고
    • Tumor necrosis factor-α regulates insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle
    • DOI 10.1161/hc1002.105187
    • Anwar A, Zahid AA, Scheidegger KJ, Brink M, Delafontaine P: Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and insulin- like growth factor binding protein-3 expression in vascular smooth muscle. Circulation 2002, 105:1220-1225 (Pubitemid 34225824)
    • (2002) Circulation , vol.105 , Issue.10 , pp. 1220-1225
    • Anwar, A.1    Zahid, A.A.2    Scheidegger, K.J.3    Brink, M.4    Delafontaine, P.5
  • 33
    • 33846986357 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptors in atherosclerotic plaques of symptomatic and asymptomatic patients with carotid stenosis: Effect of IL-12 and IFNgamma
    • Jia G, Cheng G, Soundararajan K, Agrawal DK: Insulin-like growth factor-I receptors in atherosclerotic plaques of symptomatic and asymptomatic patients with carotid stenosis: effect of IL-12 and IFNgamma. Am J Physiol Heart Circ Physiol 2007, 292:H1051-H1057
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Jia, G.1    Cheng, G.2    Soundararajan, K.3    Agrawal, D.K.4
  • 35
    • 12844286997 scopus 로고    scopus 로고
    • Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture
    • Newby AC: Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 2005, 85:1-31
    • (2005) Physiol Rev , vol.85 , pp. 1-31
    • Newby, A.C.1
  • 36
    • 27344445301 scopus 로고    scopus 로고
    • Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries
    • Johnson JL, George SJ, Newby AC, Jackson CL: Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Proc Natl Acad Sci U S A 2005, 102:15575-15580
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15575-15580
    • Johnson, J.L.1    George, S.J.2    Newby, A.C.3    Jackson, C.L.4
  • 39
    • 24144472308 scopus 로고    scopus 로고
    • Plasma matrix metalloproteinase-3 level is an independent prognostic factor in stable coronary artery disease
    • DOI 10.1111/j.1365-2362.2005.01548.x
    • Wu TC, Leu HB, Lin WT, Lin CP, Lin SJ, Chen JW: Plasma matrix metalloproteinase-3 level is an independent prognostic factor in stable coronary artery disease. Eur J Clin Invest 2005, 35:537-545 (Pubitemid 41243296)
    • (2005) European Journal of Clinical Investigation , vol.35 , Issue.9 , pp. 537-545
    • Wu, T.C.1    Leu, H.B.2    Lin, W.T.3    Lin, C.P.4    Lin, S.J.5    Chen, J.W.6
  • 41
    • 0347356291 scopus 로고    scopus 로고
    • The Role of the IGF-I Receptor in the Regulation of Matrix Metalloproteinases, Tumor Invasion and Metastasis
    • DOI 10.1055/s-2004-814143
    • Zhang D, Samani AA, Brodt P. The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis. Horm Metab Res 2003, 35:802-808 (Pubitemid 38058186)
    • (2003) Hormone and Metabolic Research , vol.35 , Issue.11-12 , pp. 802-808
    • Zhang, D.1    Samani, A.A.2    Brodt, P.3
  • 42
    • 0032129270 scopus 로고    scopus 로고
    • Regulation of the M(r) 72,000 type IV collagenase by the type I insulin- Like growth factor receptor
    • Long L, Navab R, Brodt P: Regulation of the Mr 72,000 type IV collagenase by the type I insulin-like growth factor receptor. Cancer Res 1998, 58:3243-3247 (Pubitemid 28371059)
    • (1998) Cancer Research , vol.58 , Issue.15 , pp. 3243-3247
    • Long, L.1    Navab, R.2    Brodt, P.3
  • 43
    • 0346656569 scopus 로고    scopus 로고
    • Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3 and suppresses MMP-2 expression
    • DOI 10.1002/path.1492
    • Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P: Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression. J Pathol 2004, 202:50-59 (Pubitemid 38072845)
    • (2004) Journal of Pathology , vol.202 , Issue.1 , pp. 50-59
    • Grzmil, M.1    Hemmerlein, B.2    Thelen, P.3    Schweyer, S.4    Burfiend, P.5
  • 44
    • 33748751902 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors
    • DOI 10.1074/jbc.M513513200
    • Risinger GM Jr., Hunt TS, Updike DL, Bullen EC, Howard EW: Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors. J Biol Chem 2006, 281:25915-25925 (Pubitemid 44401797)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.36 , pp. 25915-25925
    • Risinger Jr., G.M.1    Hunt, T.S.2    Updike, D.L.3    Bullen, E.C.4    Howard, E.W.5
  • 45
    • 2542466624 scopus 로고    scopus 로고
    • Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals
    • Randeva HS, Lewandowski KC, Komorowski J, Murray RD, O'Callaghan CJ, Hillhouse EW, Stepien H, Shalet SM: Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals. Circulation 2004, 109:2405-2410
    • (2004) Circulation , vol.109 , pp. 2405-2410
    • Randeva, H.S.1    Lewandowski, K.C.2    Komorowski, J.3    Murray, R.D.4    O'Callaghan, C.J.5    Hillhouse, E.W.6    Stepien, H.7    Shalet, S.M.8
  • 46
    • 0032145417 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
    • DOI 10.1006/excr.1998.4138
    • Pukac L, Huangpu J, Karnovsky MJ: Platelet-derived growth factor- BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration. Exp Cell Res 1998, 242:548-560 (Pubitemid 28359836)
    • (1998) Experimental Cell Research , vol.242 , Issue.2 , pp. 548-560
    • Pukac, L.1    Huangpu, J.2    Karnovsky, M.J.3
  • 47
    • 0035653435 scopus 로고    scopus 로고
    • Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr-/- mice
    • von der Thüsen JH, Kuiper J, Fekkes ML, De Vos P, Van Berkel TJ, Biessen EA: Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr-/- mice. FASEB J 2001, 15:2730-2732
    • (2001) FASEB J , vol.15 , pp. 2730-2732
    • Von Der Thüsen, J.H.1    Kuiper, J.2    Fekkes, M.L.3    De Vos, P.4    Van Berkel, T.J.5    Biessen, E.A.6
  • 50
    • 0036970842 scopus 로고    scopus 로고
    • The role of the IGF system in cancer: From basic to clinical studies and clinical applications
    • DOI 10.1159/000066230
    • Moschos SJ, Mantzoros CS: The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology 2002, 63:317-332 (Pubitemid 36151524)
    • (2002) Oncology , vol.63 , Issue.4 , pp. 317-332
    • Moschos, S.J.1    Mantzoros, C.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.