CD34 +CD140b + cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy

European Heart Journal

Volumn 32, Issue 4, 2011, Pages 476-484

  Schober, Andreas ^a,b   Hristov, Mihail ^b   Kofler, Sieglinde ^a   Forbrig, Robert ^a   Löhr, Barbara ^a   Heussen, Nicole ^b   Zhe, Zhou ^b   Akhtar, Shamima ^b   Schumann, Uwe ^b   Krötz, Florian ^a   Leibig, Marcus ^a   König, Andreas ^a   Kaczmarek, Ingo ^a   Reichart, Bruno ^a   Klauss, Volker ^a   Weber, Christian ^b,c   Sohn, Hae Young ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cardiac allograft vasculopathy; Chemokines; Progenitor cells; Transplantation

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; CREATININE; CYCLOSPORIN A; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RAPAMYCIN; STEROID; STROMAL CELL DERIVED FACTOR 1; TACROLIMUS; VASCULOTROPIN RECEPTOR 2;

ADULT; ARTICLE; BODY MASS; CARDIAC ALLOGRAFT VASCULOPATHY; CD34 SELECTION; CONTROLLED STUDY; CORONARY STENT; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; ENDOTHELIAL PROGENITOR CELL; FEMALE; FLOW CYTOMETRY; HEART SCINTISCANNING; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER;

ADULT; AGED; ANTIGENS, CD34; CELL PROLIFERATION; CHEMOKINE CXCL12; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; STEM CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 79951823555     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq402     Document Type: Article

References (37)

1. Taylor DO, Edwards LB, Aurora P, Christie JD, Dobbels F, Kirk R, Rahmel AO, Kucheryavaya AY, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: Twenty-Fifth Official Adult Heart Transplant Report - 2008. J Heart Lung Transplant 2008;27:943-956.
2. Schmauss D, Weis M. Cardiac allograft vasculopathy: recent developments. Circulation 2008;117:2131-2141. (Pubitemid 351596195)
3. Rahmani M, Cruz RP, Granville DJ, McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res 2006;99:801-815. (Pubitemid 44556379)
4. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res 2007;100:967-978. (Pubitemid 46598921)
5. Hristov M, Zernecke A, Schober A, Weber C. Adult progenitor cells in vascular remodeling during atherosclerosis. Biol Chem 2008;389:837-844.
6. Hristov M, Weber C. Ambivalence of progenitor cells in vascular repair and plaque stability. Curr Opin Lipidol 2008;19:491-497.
7. Hristov M, Fach C, Becker C, Heussen N, Liehn EA, Blindt R, Hanrath P, Weber C. Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment. Atherosclerosis 2007;192:413-420. (Pubitemid 46726323)
8. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, Dimmeler S, Zeiher AM. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005;111:2981-2987. (Pubitemid 40814192)
9. Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008;8:802-815.
10. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis 2006;187:351-362. (Pubitemid 43963015)
11. Zoll J, Fontaine V, Gourdy P, Barateau V, Vilar J, Leroyer A, Lopes-Kam I, Mallat Z, Arnal JF, Henry P, Tobelem G, Tedgui A. Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition. Cardiovasc Res 2008;77:471-480. (Pubitemid 351197652)
12. Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002;8:403-409. (Pubitemid 34407037)
13. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med 2001;7:738-741. (Pubitemid 32588032)
14. Glaser R, Lu MM, Narula N, Epstein JA. Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts. Circulation 2002;106:17-19. (Pubitemid 34747435)
15. Simper D, Wang S, Deb A, Holmes D, McGregor C, Frantz R, Kushwaha SS, Caplice NM. Endothelial progenitor cells are decreased in blood of cardiac allograft patients with vasculopathy and endothelial cells of noncardiac origin are enriched in transplant atherosclerosis. Circulation 2003;108:143-149. (Pubitemid 36871294)
16. Metharom P, Liu C, Wang S, Stalboerger P, Chen G, Doyle B, Ikeda Y, Caplice NM. Myeloid lineage of high proliferative potential human smooth muscle outgrowth cells circulating in blood and vasculogenic smooth muscle-like cells in vivo. Atherosclerosis 2008;198:29-38. (Pubitemid 351406365)
17. Yamani MH, Ratliff NB, Cook DJ, Tuzcu EM, Yu Y, Hobbs R, Rincon G, Bott-Silverman C, Young JB, Smedira N, Starling RC. Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1. J Am Coll Cardiol 2005;46:1029-1035. (Pubitemid 41316511)
18. Thomas HE, Parry G, Dark JH, Arthur HM, Keavney BD. Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients. Atherosclerosis 2009;202:612-616.
19. Schober A. Chemokines in vascular dysfunction and remodeling. Arterioscler Thromb Vasc Biol 2008;28:1950-1959.
20. Sakihama H, Masunaga T, Yamashita K, Hashimoto T, Inobe M, Todo S, Uede T. Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis. Circulation 2004;110:2924-2930. (Pubitemid 39473619)
21. Zernecke A, Schober A, Bot I, von Hundelshausen P, Liehn EA, Mopps B, Mericskay M, Gierschik P, Biessen EA, Weber C. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res 2005;96:784-791. (Pubitemid 40559518)
22. Kaczmarek I, Ertl B, Schmauss D, Sadoni S, Knez A, Daebritz S, Meiser B, Reichart B. Preventing cardiac allograft vasculopathy: long-term beneficial effects of mycophenolate mofetil. J Heart Lung Transplant 2006;25:550-556.
23. Konig A, Kilian E, Sohn HY, Rieber J, Schiele TM, Siebert U, Gothe RM, Reichart B, Klauss V. Assessment and characterization of time-related differences in plaque composition by intravascular ultrasound-derived radiofrequency analysis in heart transplant recipients. J Heart Lung Transplant 2008;27:302-309. (Pubitemid 351375110)
24. Raichlin E, Bae JH, Kushwaha SS, Lennon RJ, Prasad A, Rihal CS, Lerman A. Inflammatory burden of cardiac allograft coronary atherosclerotic plaque is associated with early recurrent cellular rejection and predicts a higher risk of vasculopathy progression. J Am Coll Cardiol 2009;53:1279-1286.
25. Simper D, Stalboerger PG, Panetta CJ, Wang S, Caplice NM. Smooth muscle progenitor cells in human blood. Circulation 2002;106:1199-1204. (Pubitemid 34988636)
26. Schober A, Hoffmann R, Opree N, Knarren S, Iofina E, Hutschenreuter G, Hanrath P, Weber C. Peripheral CD34+ cells and the risk of in-stent restenosis in patients with coronary heart disease. Am J Cardiol 2005;96:1116-1122. (Pubitemid 41416606)
27. Inoue T, Sata M, Hikichi Y, Sohma R, Fukuda D, Uchida T, Shimizu M, Komoda H, Node K. Mobilization of CD34-positive bone marrow-derived cells after coronary stent implantation: impact on restenosis. Circulation 2007;115:553-561. (Pubitemid 46226164)
28. Hillebrands JL, Klatter FA, van den Hurk BM, Popa ER, Nieuwenhuis P, Rozing J.: Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest 2001;107:1411-1422. (Pubitemid 32522035)
29. Fadini GP, Baesso I, Albiero M, Sartore S, Agostini C, Avogaro A. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis 2008;197:496-503.
30. Timmermans F, Van Hauwermeiren F, De Smedt M, Raedt R, Plasschaert F, De Buyzere ML, Gillebert TC, Plum J, Vandekerckhove B. Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors. Arterioscler Thromb Vasc Biol 2007;27:1572-1579. (Pubitemid 46986112)
31. Sathya CJ, Sheshgiri R, Prodger J, Tumiati L, Delgado D, Ross HJ, Rao V. Correlation between circulating endothelial progenitor cell function and allograft rejection in heart transplant patients. Transpl Int 2010;23:641-648.
32. de Groot K, Bahlmann FH, Sowa J, Koenig J, Menne J, Haller H, Fliser D. Uremia causes endothelial progenitor cell deficiency. Kidney Int. 2004;66:641-646. (Pubitemid 38982006)
33. Raines EW. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 2004;15:237-254. (Pubitemid 38781049)
34. Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999;126:3047-3055. (Pubitemid 29378170)
35. Schober A, Knarren S, Lietz M, Lin EA, Weber C. Crucial role of stromal cell-derived factor-1alpha in neointima formation after vascular injury in apolipoprotein E-deficient mice. Circulation 2003;108:2491-2497. (Pubitemid 37444411)
36. Legare JF, Issekutz T, Lee TD, Hirsch G. CD8+ T lymphocytes mediate destruction of the vascular media in a model of chronic rejection. Am J Pathol 2000;157:859-865. (Pubitemid 32109378)
37. Religa P, Bojakowski K, Bojakowska M, Gaciong Z, Thyberg J, Hedin U. Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis. Cardiovasc Res 2005;65:535-545. (Pubitemid 40082495)