Correlation between circulating endothelial progenitor cell function and allograft rejection in heart transplant patients

Transplant International

Volumn 23, Issue 6, 2010, Pages 641-648

  Sathya, Chethan J ^a   Sheshgiri, Rohit ^a   Prodger, Jessica ^a   Tumiati, Laura ^a   Delgado, Diego ^a   Ross, Heather J ^a   Rao, Vivek ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Cardiac allograft vasculopathy; Endothelial progenitor cell; Heart transplantation; Rejection; Sirolimus

Indexed keywords

BASILIXIMAB; CYCLOSPORIN; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RABBIT ANTITHYMOCYTE GLOBULIN; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; MTOR PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ACUTE GRAFT REJECTION; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CARDIOMYOPATHY; CELL COUNT; CELL FUNCTION; CHRONIC GRAFT REJECTION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COLONY FORMING UNIT; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; DRUG EFFICACY; ENDOTHELIAL PROGENITOR CELL; FEMALE; FUNCTIONAL STATUS; GRAFT RECIPIENT; GRAFT REJECTION; HEART DISEASE; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RISK FACTOR; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CFU COUNTING; ENDOTHELIUM CELL; IMMUNOLOGY; MIDDLE AGED; PHYSIOLOGY; RETROSPECTIVE STUDY; RISK; STEM CELL;

ADULT; AGED; COLONY-FORMING UNITS ASSAY; ENDOTHELIAL CELLS; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; RETROSPECTIVE STUDIES; RISK; SIROLIMUS; STEM CELLS; TOR SERINE-THREONINE KINASES;

EID: 77951963246     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2009.01043.x     Document Type: Article

References (26)

1. Ramzy D, Rao V, Brahm J, Miriuka S, Delgado D, Ross HJ. Cardiac allograft vasculopathy: a review. Can J Surg 2005 48 : 319. (Pubitemid 41297336)
2. Hertz MI, Taylor DO, Trulock EP, et al. The registry of the International Society for Heart and Lung Transplantation: nineteenth official report - 2002. J Heart Lung Transplant 2002 21 : 950.
3. Mitchell R, Libby P. Vascular remodeling in transplant vasculopathy. Circulation 2007 100 : 967. (Pubitemid 46598921)
4. Hillebrands JL, Onuta G, Rozing J. Role of progenitor cells in transplant arteriosclerosis. Trends Cardiovasc Med 2005 15 : 1141. (Pubitemid 40417539)
5. Szmitko P, Fedak PW, Weisel RD, Stewart DJ, Kutryk MJ, Verma S. Endothelial progenitor cells; a new hope for a broken heart. Circulation 2003 107 : 3093. (Pubitemid 36758985)
6. Hristov M, Weber C. Endothelial progenitor cells, characterization, pathophysiology, and possible clinical relevance. J Cell Mol Med 2004 8 : 498. (Pubitemid 44145482)
7. Roberts N, Jahangiri M, Xu Q. Progenitor cells in vascular disease. J Cell Mol Med 2005 9 : 583. (Pubitemid 44159326)
8. Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003 348 : 593. (Pubitemid 36204953)
9. Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001 89 : E1.
10. Werner N, Kosiol S, Schiegl T, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005 353 : 999. (Pubitemid 41262334)
11. Chironi G, Walch L, Pernollet MG, et al. Decreased number of circulating CD34+ KDR+ cells in asymptomatic subjects with preclinical atherosclerosis. Atherosclerosis 2007 191 : 115. (Pubitemid 46237627)
12. Fadini GP, Coracina A, Baesso I, et al. Peripheral blood CD34+ KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population. Stroke 2006 37 : 2277. (Pubitemid 44337169)
13. Woywodt A, Schroeder M, Gwinner W, et al. Elevated number of circulating endothelial progenitor cells in renal transplant patient. Transplantation 2004 77 : 1517.
14. Simper D, Wang S, Deb A, et al. Endothelial progenitor cells are decreased in blood of cardiac allograft patients with vasculopathy and endothelial cells of noncardiac origin are enriched in transplant atherosclerosis. Circulation 2003 108 : 143. (Pubitemid 36871294)
15. Yamashita J, Itoh H, Hirashima M, et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000 408 : 92.
16. Xiao Q, Zeng L, Zhang Z, et al. Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury. Arterioscler Thromb Vasc Biol 2006 26 : 2244. (Pubitemid 44465718)
17. Hillebrands JL, Klatter FA, van den Hurk BM, Popa ER, Nieuwenhuis P, Rozing J. Origin of neointimal endothelium and α-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest 2001 107 : 1411. (Pubitemid 32522035)
18. Hu Y, Davison F, Zhang Z, Xu Q. Endothelial replacement and angiogenesis in arteriosclerotic lesions of allografts are contributed by circulating progenitor cells. Circulation 2003 108 : 3122. (Pubitemid 38031802)
19. Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 2004 110 : 2694. (Pubitemid 39453021)
20. Miriuka SG, Rao V, Peterson M, et al. mTOR inhibition induces endothelial progenitor cell death. Am J Transplant 2006 6 : 2069. (Pubitemid 44199541)
21. Butzal M, Loges S, Schweizer M, et al. Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro. Exp Cell Res 2004 300 : 65. (Pubitemid 39286218)
22. Chen TG, Chen JZ, Wang XX. Effects of rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood. Cell Prolif 2006 39 : 117.
23. Inoue T, Sata M, Hikichi Y, et al. Mobilization of CD34-positive bone marrow-derived cells after coronary stent implantation: impact on restenosis. Circulation 2007 115 : 553. (Pubitemid 46226164)
24. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005 24 : 1710. (Pubitemid 41641841)
25. Prater DN, Case J, Ingram DA, Yoder MC. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007 21 : 1141. (Pubitemid 46831802)
26. Timmermans F, Van Hauwermeiren F, De Smedt M, et al. Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors. Arterioscler Thromb Vasc Biol 2007 27 : 1572. (Pubitemid 46986112)