Formulation of indomethacin eye drops via complexation with cyclodextrins

Current Eye Research

Volumn 36, Issue 3, 2011, Pages 208-216

  Halim Mohamed, Maaly A ^a   Mahmoud, Azza A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Complexation; Cyclodextrin; Indomethacin; Inflammation; Stability

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN SULFOBUTYL ETHER; DICLOFENAC; EYE DROPS; INDOMETACIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; EYE INJURY; HISTOLOGY; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; RABBIT; X RAY DIFFRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; BURNS, CHEMICAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; EYE BURNS; INDOMETHACIN; MALE; OPHTHALMIC SOLUTIONS; RABBITS; SODIUM HYDROXIDE; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; X-RAY DIFFRACTION;

EID: 79951815031     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2010.536294     Document Type: Article

References (38)

1. Araujo J, Gonzalez E, Egea MA, et al. Nanomedicines for ocular NSAIDs: Safety on drug delivery. Nanomedicine. 2009;5:394-401.
2. Heier JS, Topping TM, Baumann W, et al. Ketorolac versus prednisolone versus combination therapy in the treatment of acute pseudophakic cystoid macular edema. Ophthalmology. 2000;107:2034-2038; discussion 2039.
3. O'Brien TP. Emerging guidelines for use of NSAID therapy to optimize cataract surgery patient care. Curr Med Res Opin. 2005;21:1131-1137.
4. Bechetoille A, Chabanais JL, Jallet G, et al. Contusion and permeability of the hemato-aqueous barrier to fluorescein. Effect of a pretreatment by local indometacine. J Fr Ophthalmol. 1978;1:139-143.
5. Kahan LI, Bi J, Farkas A, et al. Indosol-a nonsteroidal anti-inflammatory drug with therapeutic efficacy. Acta Pharmaceutica Hungarica. 1994;64:125-129. (Pubitemid 24269112)
6. Mochizuki M, Sawa M, Masuda K. Topical indomethacin in intracapsular extraction of senile cataract. Jpn J Ophthalmol. 1977;21:215-226. (Pubitemid 8186541)
7. Donald R, Sanders MD, Manus C, et al. Breakdown and reestablishment of blood-aqueous barrier with implant surgery. Arch Ophthalmol. 1982;100:588-590.
8. Miyake K. Studies on clinical pathophysiology of pseudophakic/aphakic eyes-A journey of 4 decades]. Nippon Ganka Gakkai Zasshi. 2008;112:214-245; discussion 246.
9. Dube P, Boisjoly HM, Bazin R, et al. Comparison of prednisolone acetate and indomethacin for maintaining mydriasis during cataract surgery. Can J Ophthalmol. 1990;25:234-238. (Pubitemid 20289520)
10. Backensfeld T, Muller BW, Wiese M, et al. Effect of cyclodextrin derivatives on indomethacin stability in aqueous solution. Pharm Res. 1990;7:484-490. (Pubitemid 20322198)
11. Loftssona T, Jarvinen T. Cyclodextrins in ophthalmic drug delivery. Adv Drug Deliv Rev. 1999;36:59-79. (Pubitemid 29074477)
12. Sigurdsson HH, Stefansson E, Gudmundsdottir E, et al. Cyclodextrin formulation of dorzolamide and its distribution in the eye after topical administration. J Control Release. 2005;102:255-262. (Pubitemid 40093790)
13. Loftsson T, Stefansson E. Cyclodextrins in eye drop formulations: Enhanced topical delivery of corticosteroids to the eye. Acta Ophthalmol Scand. 2002;80:144-150. (Pubitemid 34406845)
14. Loftsson T, Stefansson E, Kristinsson JK, et al. Topically effective acetazolamide eye-drop solution in man. Pharm Sci Technol Today. 1996;6:277-279. (Pubitemid 28121824)
15. Jarvinen T, Jarvinen K, Urtti A, et al. Sulfobutyl ether betacyclodextrin (SBE-beta-CD) in eyedrops improves the tolerability of a topically applied pilocarpine prodrug in rabbits. J Ocul Pharmacol Ther. 1995;11:95-106.
16. Jarho P, Jarvinen K, Urtti A, et al. Modified beta-cyclodextrin (SBE7-beta-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits. J Pharm Pharmacol. 1996;48:263-269. (Pubitemid 26159141)
17. Higuchi T, Connors KA. Phase solubility technique. Adv Anal Chem Instrum. 1965;4:117-212.
18. Miyazaki S, Suzuki S, Kawasaki N, et al. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm. 2001;229:29-36. (Pubitemid 32972078)
19. Wu C, Qi H, Chen W, et al. Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. Yakugaku Zasshi. 2007;127: 183-191. (Pubitemid 46089916)
20. U.S. Department of Health and Human Services. Guidance for industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms. Food and Drug Administration Center for Drug Evaluation and Research (CDER), 1997.
21. Brian MO, McCauley J, Cohen E. In: Florey K (Eds.). Analytical Profiles of Drug Substances, Orlando, FL: Academic Press, 1984; pp. 211-238.
22. Draize JH, Woodard G, Calvey HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 1944;82:377-390.
23. Liu Z, Li J, Nie S, et al. Effects of Transcutol P on the corneal permeability of drugs and evaluation of its ocular irritation of rabbit eyes. J Pharm Pharmacol. 2006;58:45-50. (Pubitemid 43041995)
24. Aasuri MK, Venkata N, Kumar VM. Differential diagnosis of microbial keratitis and contact lens-induced peripheral ulcer. Eye Contact Lens. 2003;29:S60-S62; discussion S83-S84, S192-S194.
25. Chowdhury P, Panja S, Chakravorti S. Photophysical behaviour of 4-(imidazole-1-yl) phenol and its complexation with beta-cyclodextrin in ground and excited states. Spectrochim Acta A Mol Biomol Spectrosc. 2004;60:2295-2303.
26. Ventura CA, Giannone I, Musumeci T, et al. Physicochemical characterization of disoxaril-dimethyl-beta- cyclodextrin inclusion complex and in vitro permeation studies. Eur J Med Chem. 2006;41:233-240.
27. Loftsson T, Mson M, Sigurjsdtir JF. Methods to enhance the complexation efficiency of cyclodextrins. STP Pharma Sci. 1999;9:237-242. (Pubitemid 29337076)
28. Loftsson I, Stefansson E. Effect of cyclodextrins on topical drug delivery to the eye. Drug Devel Ind Pharm. 1997;23:473-481. (Pubitemid 27241126)
29. Blaug SM, Canada Jr. AT. Relationship of viscosity, contact time and prolongation of action of methylcellulosecontaining ophthalmic solutions. Am J Hosp Pharm. 1965;22:662-666.
30. Urtti A, Salminen L. Minimizing systemic absorption of topically administered ophthalmic drugs. Surv Ophthalmol. 1993;37:435-456. (Pubitemid 23144013)
31. Badr-Eldin SM, Elkheshen SA, Ghorab MM. Inclusion complexes of tadalafil with natural and chemically modified beta-cyclodextrins. I: Preparation and in-vitro evaluation. Eur J Pharm Biopharm. 2008;70:819-827.
32. Ruan LP, Yu BY, Fu GM, et al. Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. J Pharm Biomed Anal. 2005;38:457-464.
33. Redenti E, Peveri T, Zanol M, et al. A study on the differentiation between amorphous piroxicam: β-cyclodextrin complex and a mixture of the two amorphous components. Int J Pharm. 1996;129:289-294.
34. Liu J, Qiu L, Gao J, et al. Preparation, characterization and in vivo evaluation of formulation of baicalein with hydrox ypropyl-beta-cyclodextrin. Int J Pharm. 2006;312:137-143.
35. Mura P, Adragna E, Rabasco AM, et al. Effects of the host cavity size and the preparation method on the physicochemical properties of ibuproxam-cyclodextrin systems. Drug Dev Ind Pharm. 1999;25:279-287. (Pubitemid 29108674)
36. Proniuk S, Liederer BM, Dixon SE, et al. Topical formulation studies with DEET (N,N-diethyl-3-methylbenzamide) and cyclodextrins. J Pharm Sci. 2002;91:101-110. (Pubitemid 34074470)
37. Davaran S, Rashidi MR, Khandaghi R, et al. Development of a novel prolonged-release nicotine transdermal patch. Pharmacol Res. 2005;51:233-237. (Pubitemid 40127215)
38. Loftsson T, Brewster ME. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci. 1996;85:1017-1025. (Pubitemid 26338912)