Development of a highly immunogenic recombinant candidate vaccine against human chorionic gonadotropin

Vaccine

Volumn 29, Issue 12, 2011, Pages 2341-2348

  Purswani, Shilpi ^a   Talwar, G P ^a  

^a Talwar Research Foundation   (India)

Author keywords

HCG bioneutralization; Mycobacterium indicus pranii (MIP); Pichia pastoris

Indexed keywords

ALPHA 1 MICROGLOBULIN; ALUMINUM HYDROXIDE; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN ANTIBODY; ESCHERICHIA COLI ENTEROTOXIN; HUMAN CHORIONIC GONADOTROPIN HEAT LABILE ENTEROTOXIN SUBUNIT B FUSION PROTEIN; HYBRID PROTEIN; MYCOBACTERIUM VACCINE; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; FEMALE; IMMUNE RESPONSE; IMMUNOCONTRACEPTION; IMMUNOGENICITY; MOUSE; MYCOBACTERIUM; NONHUMAN; PICHIA PASTORIS; PREGNANCY; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, NEUTRALIZING; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; CLONING, MOLECULAR; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PICHIA; RECOMBINANT FUSION PROTEINS; VACCINES, CONTRACEPTIVE; VACCINES, SYNTHETIC;

EID: 79951811936     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.11.069     Document Type: Article

References (28)

1. Iles R.K. Ectopic hCGβ expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis. Mol Cell Endocrinol 2007, 260-262:264-270.
2. Talwar G.P., Sharma N.C., Dubey S.K., Salahuddin M., Das C., Ramakrishnan S.K., et al. Isoimmunisation against human chorionic gonadotropin with conjugates of processed beta subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci USA 1976, 73:218-222.
3. Nash H., Talwar G.P., Segal S., Luukkainen T., Johanson E.D.B., Vasquez J., et al. Observation on the antigenecity and clinical effects of a candidate antipregnancy vaccine: B-subunit of human chorionic gonadotropin linked to tetanus toxoid. Fertil Steril 1980, 34:328-335.
4. Talwar G.P., Hingorani V., Kumar S., Roy S., Banerjee A.K., Shahini S.M., et al. Phase I clinical trials with three formulations of anti-human chorionic gonadotropin vaccine. Contraception 1990, 41:301-316.
5. Kharat I., Nair N.S., Dhall K., Sawhney H., Krishna O., Shahani S.M., et al. Analysis of menstrual records of women immunized with anti-hCG vaccine inducing antibodies partly cross-reactive with hLH. Contraception 1990, 41:293-299.
6. Talwar G.P., Singh O., Pal R., Chatterjee N., Sahai P., Dhall K., et al. A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 1994, 91:8532-8536.
7. Singh M., Das S.K., Suri S., Singh O., Talwar G.P. Regain of fertility and normality of progeny born during below protective threshold antibody titers in women immunized with the HSD-hCG vaccine. Am J Reprod Immunol 1998, 39:395-398.
8. Talwar G.P., Singh O., Gupta S.K., Hasnain S.E., Pal R., Majumdar S.S., et al. The HSD-hCG vaccine prevents pregnancy in women, fesability studies of reversibile safe contraception vaccine. Am J Reprod Immunol 1997, 37:153-160.
9. Spangler B.D. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microb Rev 1992, 56:622-647.
10. Haan L.D., Verwij W.R., Holtrop M., Brands R., Van Scharrenburg G.J.M., Palache A.M., et al. Nasal or intramuscular immunization of mice with influenza subunit antigen and the B subunit of heat-labile toxin induces IgA- and IgG-mediated protective mucosal immunity. Vaccine 2001, 19:2898-2907.
11. Millar D.G., Hirst T.R., Snider D.P. Escherichia coli heat-labile enterotoxin B subunit is a more potent mucosal adjuvant than its closely related homologue, The B subunit of cholera toxin. Infect Immun 2001, 69:3476-3482.
12. Bone H., Eckholdt S., Williams N.A. Modulation of B lymphocyte signaling by the B subunit of Escherichia coli heat-labile enterotoxin. Int Immunol 2002, 14:647-658.
13. Fingerut E., Gutter B., Meir R., Eliahoo D., Pitcovski J. Vaccine and adjuvant activity of recombinant subunit B of E. coli enterotoxin produced in yeast. Vaccine 2005, 23:4685-4696.
14. Chatterji U., Ahmad R., Venkaiah B., Hasnain S.E. A recombination-efficient baculovirus vector for simultaneous expression of multiple genes. Gene 1996, 171:209-213.
15. Pillai D., Dixit A., Alok D., Garg L. Translational fusion of heat-labile enterotoxin chain B and β-subunit of human chorionic gonadotropin: periplasmic expression in Escherichia coli and its immunogenicity. FEBS Lett 1996, 387:23-26.
16. Kathuria S., Nath R., Pal R., Singh O., Fischer R., Lohiya N.K., et al. Functional recombinant antibodies against human chorionic gonadotropin expressed in plants. Curr Sci 2002, 82:1452-1457.
17. A novel vaccine composition inducing bioeffective immune response against human chorionic gonadotropin. Indian Patent Application No. 524/DEL/2009.
18. Saini V., Raghuvanshi S., Talwar G.P., Ahmed N., Khurana J.P., Hasnain S.E., et al. Establishment of Mycobacterium 1 w as a distinct species: polyphasic taxonomic analysis and proposal for renaming Mw as M. indicus pranii comb. nov. PLoS ONE 2009, 4:e6263.
19. Fraker P.J., Speck J.C. Protein and cell membrane iodination with asparingly soluble chloramide 1,3,4,6-tetrachloro-3a-6a-diphenylglycouril. Biochem Biophys Res Commun 1978, 80:849-855.
20. Pal R., Singh O., Rao L.V., Talwar G.P. Bioneutralization capacity of the antibodies generated in women by the beta subunit of human chorionic gonadotropin (beta hCG) and beta hCG associated with the alpha subunit of ovine luteinizing hormone linked to carriers. Am J Reprod Immunol 1990, 22:124-126.
21. Talwar G.P., Vyas H.K., Purswani S., Gupta J.C. Gonadotropin-releasing hormone/human chorionic gonadotropin β based recombinant antibodies and vaccines. J Reprod Immunol 2009, 83:158-163.
22. Talwar G.P., et al. Development of a vaccine against leprosy. Lepr India 1978, 50:492-497. [14 papers Golden Jubilee issue].
23. Talwar G.P., Singh O., Rao L.V. An improved immunogen for anti hCG vaccine eliciting antibodies reactive with a conformation native to the hormone without cross reaction with human follicle stimulating hormone. J Reprod Immunol 1988, 14:203-212.
24. Valenzuela P., Medina A., Rutter W.J., Ammerer G., Hall B.D. Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature 1982, 298:347-350.
25. Tsai C.W., Duggan P.F., Shimp R.L., Miller L.H., Narum D.L. Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris. J Biotechnol 2006, 121:458-470.
26. Gaur A., Arunan K., Singh O., Talwar G.P. Bypass by an alternate carrier of acquired unresponsiveness to hCG upon repeated immunization with tetanus conjugated vaccine. Int Immunol 1990, 2:151-155.
27. Talwar G.P., Vyas H.K., Puurswani S., Gupta J.C. Gonadotropin-releasing hormone/human chorionic gonadotropin beta based recombinant antibodies and vaccines. J Reprod Immunol 2009, 83:158-163.
28. Talwar G.P. An immunotherapeutic vaccine for multibacillary leprosy. Intl Rev Immunol 1999, 18:229-249.