A comprehensive characterization study of human bone marrow mscs with an emphasis on molecular and ultrastructural properties

Journal of Cellular Physiology

Volumn 226, Issue 5, 2011, Pages 1367-1382

  Karaöz, Erdal ^a   Okçu, Alparslan ^a   Gacar, Gülçin ^a   Saǧlam, Özlem ^a   Yürüker, Sinan ^b   Kenar, Halime ^a  

^a KOCAELI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOPHILIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; EXONUCLEASE; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOCALCIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RNA EXONUCLEASE 1; TELOMERASE; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW; CELL AGING; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CHILD; CLINICAL ARTICLE; CYTOPLASM; ECTODERM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC STABILITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; MESODERM; MITOCHONDRION; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADIPOGENESIS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CHONDROGENESIS; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, TRANSMISSION; MUSCLE DEVELOPMENT; NEUROGENESIS; OCTAMER TRANSCRIPTION FACTOR-3; OSTEOGENESIS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOXB1 TRANSCRIPTION FACTORS; TELOMERASE; TIME FACTORS;

EID: 79951795484     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22468     Document Type: Article

References (43)

1. Annabi B, Lee YT, Turcotte S, Naud E, Desrosiers RR, Champagne M, Eliopoulos N, Galipeau J, Béliveau R. 2003. Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 21: 337-347.
2. Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I. 2004. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22: 675-682.
3. Bieback K, Hecker A, Kocaömer A, Lannert H, Schallmoser K, Strunk D, Klüter H. 2009. Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Stem Cells 27: 2331-2341.
4. Chen L, Tredget EE, Wu PY, Wu Y. 2008. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3: e1886.
5. Chen M-Y, Lie P-C, Li Z-L, Wei X. 2009. Endothelial differentiation of Wharton's jelly-derived mesenchymal stem cells in comparison with bone marrow-derived mesenchymal stem cells. Exp Hematol 37: 629-640.
6. Dash NR, Dash SN, Routray P, Mohapatra S, Mohapatra PC. 2009. Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res 12: 359-366.
7. Doucet C, Ernou I, Zhang Y, Llense JR, Begot L, Holy X, Lataillade JJ. 2005. Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell-based therapy applications. J Cell Physiol 205: 228-236.
8. Fathke C, Wilson L, Hutter J, Kapoor V, Smith A, Hocking A, Isik F. 2004. Contribution of bone marrow-derived cells to skin: Collagen deposition and wound repair. Stem Cells 22: 812-822.
9. Fraser JK, Wulur I, Alfonso Z, Hedrick MH. 2006. Fat tissue: An underappreciated source of stem cells for biotechnology. Trends Biotechnol 24: 150-154.
10. Friedenstein AJ, Gorskaja JF, Kulagina NN. 1976. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4: 267-274.
11. Greco SJ, Liu K, Rameshwar P. 2007. Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells 25: 3143-3154.
12. Gry M, Rimini R, Strömberg S, Asplund A, Ponten F, Uhlen M, Nilsson P. 2009. Correlations between RNA and protein expression profiles in 23 human cell lines. BMC Genomics 10: 365.
13. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T. 2002. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 99: 8932-8937.
14. Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM, Bunnell BA. 2006. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 99: 1285-1297.
15. Jones EA, English A, Kinsey SE, Straszynski L, Emery P, Ponchel F, McGonagle D. 2006. Optimization of a flow cytometry-based protocol for detection and phenotypic characterization of multipotent mesenchymal stromal cells from human bone marrow. Cytometry B Clin Cytom 70: 391-399.
16. Kode JA, Mukherjee S, Joglekar MV, Hardikar AA. 2009. Mesenchymal stem cells: Immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 11: 377-391.
17. Kucia M, Reca R, Campbell FR, Zuba-Surma E, Majka M, Ratajczak J, Ratajczak MZ. 2006. A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia 20: 857-869.
18. Lin JR, Guo KY, Li JQ, Yan DA. 2003. In vitro culture of human bone marrow mesenchymal stem cell clonies and induced differentiation into neuron-like cells. Di Yi Jun Yi Da Xue Xue Bao 23: 251-253; 264.
19. + channel types. Exp Hematol 34: 1563-1572.
20. Newman RE, Yoo D, LeRoux MA, Danilkovitch-Miagkova A. 2009. Treatment of inflammatory diseases with mesenchymal stem cells. Inflamm Allergy Drug Targets 8: 110-123.
21. Nimura A, Muneta T, Koga H, Mochizuki T, Suzuki K, Makino H, Umezawa A, Sekiya I. 2008. Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: Comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum. Arthritis Rheum 58: 501-510.
22. Pasquinelli G, Tazzari P, Ricci F, Vaselli C, Buzzi M, Conte R, Orrico C, Foroni L, Stella A, Alviano F, Bagnara GP, Lucarelli E. 2007. Ultrastructural characteristics of human mesenchymal stromal (stem) cells derived from bone marrow and term placenta. Ultrastruct Pathol 31: 23-31.
23. Piryaei A, Valojerdi MR, Shahsavani M, Baharvand H. 2010. Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells on nanofibers and their transplantation into a carbon tetrachloride-induced liver fibrosis model. Stem Cell Rev DOI: 10.1007/s12015-010-9126-5.
24. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147.
25. Ratajczak MZ, Kucia M, Majka M, Reca R, Ratajczak J. 2004. Heterogeneous populations of bone marrow stem cells- are we spotting on the same cells from the different angles? Folia Histochem Cytobiol 42: 139-146.
26. Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, Verfaillie CM. 2002. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 109: 337-346.
27. Sansom DM, Manzotti CN, Zheng Y. 2003. What's the difference between CD80 and CD86? Trends Immunol. 24: 314-319.
28. Schallmoser K, Bartmann C, Rohde E, Reinisch A, Kashofer K, Stadelmeyer E, Drexler C, Lanzer G, Linkesch W, Strunk D. 2007. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 47: 1436-1446.
29. Schallmoser K, Rohde E, Reinisch A, Bartmann C, Thaler D, Drexler C, Obenauf AC, Lanzer G, Linkesch W, Strunk D. 2008. Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum. Tissue Eng Part C Methods 14: 185-196.
30. Schinköthe T, Bloch W, Schmidt A. 2008. In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev 17: 199-206.
31. Selvaggi TA, Walker RE, Fleisher TA. 1997. Development of antibodies to fetal calf serum with Arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions. Blood 89: 776-779.
32. Serakinci N, Graakjaer J, Kolvraa S. 2008. Telomere stability and telomerase in mesenchymal stem cells. Biochimie 90: 33-40.
33. Snykers S, De Kock J, Rogiers V, Vanhaecke T. 2009. In vitro differentiation of embryonic and adult stem cells into hepatocytes: State of the art. Stem Cells 27: 577-605.
34. Squillaro T, Hayek G, Farina E, Cipollaro M, Renieri A, Galderisi U. 2008. A case report: Bone marrow mesenchymal stem cells from a Rett syndrome patient are prone to senescence and show a lower degree of apoptosis. J Cell Biochem 103: 1877-1885.
35. Sundin M, Ringdén O, Sundberg B, Nava S, Götherström C, Le Blanc K. 2007. No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients. Haematologica 92: 1208-1215.
36. Tao XR, Li WL, Su J, Jin CX, Wang XM, Li JX, Hu JK, Xiang ZH, Lau JT, Hu YP. 2009. Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice. J Cell Biochem 108: 693-704. Trends Immunol 24:6, 314-319.
37. Tondreau T, Lagneaux L, Dejeneffe M, Delforge A, Massy M, Mortier C, Bron D. 2004. Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: Phenotype, proliferation kinetics and differentiation potential. Cytotherapy 6: 372-379.
38. Turnovcova K, Ruzickova K, Vanecek V, Sykova E, Jendelova P. 2009. Properties and growth of human bone marrow mesenchymal stromal cells cultivated in different media. Cytotherapy 11: 874-885.
39. Tuschong L, Soenen SL, Blaese RM, Candotti F, Muul LM. 2002. Immune response to fetal calf serum by two adenosine deaminase deficient patients after T cell gene therapy. Hum Gene Ther 13: 1605-1610.
40. Wagner W, Bork S, Horn P, Krunic D, Walenda T, Diehlmann A, Benes V, Blake J, Huber FX, Eckstein V, Boukamp P, Ho AD. 2009. Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One 4: e5846.
41. Zhao YM, Li JY, Lan JP, Lai XY, Luo Y, Sun J, Yu J, Zhu YY, Zeng FF, Zhou Q, Huang H. 2008. Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 369: 1114-1119.
42. Zhu XY, Zhou YH, Wang MY, Jin LP, Yuan MM, Li DJ. 2005. Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol Reprod 72: 338-345.
43. Zimmermann S, Voss M, Kaiser S, Kapp U, Waller CF, Martens UM. 2003. Lack of telomerase activity in human mesenchymal stem cells. Leukemia 17: 1146-1149.