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The common feature of Leukemia-Associated IDH1 and IDH2 Mutations is a neomorphic enzyme activity converting alpha-Ketoglutarate to 2-Hydroxyglutarate
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Molecular signatures classify astrocytic gliomas by IDH1 mutation status
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Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, Sabel MC, Hofmann S, Becker N, Hartmann C, Ohgaki H, von Deimling A, Wiestler OD, Hahn M, Lichter P, Reifenberger G, Radlwimmer B. Molecular signatures classify astrocytic gliomas by IDH1 mutation status. Int J Cancer 2010; [Epub ahead of print]. DOI: 10.1002/ijc.25448.
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All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2
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Labussiere M, Idbaih A, Wang XW, Marie Y, Boisselier B, Falet C, Paris S, Laffaire J, Carpentier C, Criniere E, Ducray F, El Hallani S, Mokhtari K, Hoang-Xuan K, Delattre JY, Sanson M. All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2. Neurology 2010; 74: 1886-90
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