Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: A post hoc analysis of the hypothermia pediatric head injury trial

Developmental Neuroscience

Volumn 32, Issue 5-6, 2011, Pages 406-412

  Hutchison, James S ^a,b,c   Frndova, Helena ^a   Lo, Tsz Yan M ^a,b   Guerguerian, Anne Marie ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cerebral perfusion pressure; Children; Hypotension; Hypothermia therapy; Traumatic brain injury

Indexed keywords

INOTROPIC AGENT;

ARTICLE; BODY TEMPERATURE; BRAIN PERFUSION; CHILD; CONTROLLED STUDY; DATA BASE; DISEASE SEVERITY; FLUID THERAPY; HEAD INJURY; HUMAN; HYPOTENSION; HYPOTHERMIA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PERFUSION PRESSURE; PHYSIOLOGICAL STRESS; POST HOC ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; TRAUMATIC BRAIN INJURY;

BRAIN; BRAIN INJURIES; CEREBROVASCULAR CIRCULATION; CHILD; HUMANS; HYPOTENSION; HYPOTHERMIA, INDUCED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REGRESSION ANALYSIS; TREATMENT OUTCOME;

EID: 79951780617     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323260     Document Type: Article

References (24)

1. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, et al: The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34: 216-222. (Pubitemid 23111023)
2. Chambers IR, Treadwell L, Mendelow AD: Determination of threshold levels of cerebral perfusion pressure and intracranial pressure in severe head injury by using receiver-operating characteristic curves: an observational study in 291 patients. J Neurosurg 2001; 94: 412-416. (Pubitemid 32786019)
3. Pigula FA, Wald SL, Shackford SR, Vane DW: The effect of hypotension and hypoxia on children with severe head injuries. J Pediatr Surg 1993; 28: 310-314.
4. Kokoska ER, Smith GS, Pittman T, Weber TR: Early hypotension worsens neurological outcome in pediatric patients with moderately severe head trauma. J Pediatr Surg 1998; 33: 333-338. (Pubitemid 28093724)
5. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, et al: Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001; 344: 556-563. (Pubitemid 32167869)
6. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al: Hypothermia therapy after traumatic brain injury in children. N Engl J Med 2008; 358: 2447-2456. (Pubitemid 351793018)
7. Abramson NS, Meisel A, Safar P: Deferred consent: a new approach for resuscitation research on comatose patients. JAMA 1986; 255: 2466-2471. (Pubitemid 16104006)
8. Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, et al: Hypothermia Pediatric Head Injury Trial: the value of a pretrial clinical evaluation phase. Dev Neurosci 2006; 28: 291-301. (Pubitemid 44310495)
9. Fiser DH: Assessing the outcome of pediatric intensive care. J Pediatr 1992; 121: 68-74.
10. Fiser DH, Tilford JM, Roberson PK: Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit: a multi-institutional study. Crit Care Med 2000; 28: 1173-1179. (Pubitemid 30262097)
11. The International Liaison Committee on Resuscitation (ILCOR) consensus on science with treatment recommendations for pediatric and neonatal patients: pediatric basic and advanced life support. Pediatrics 2006; 117:e955-e977.
12. Haque IU, Zaritsky AL: Analysis of the evidence for the lower limit of systolic and mean arterial pressure in children. Pediatr Crit Care Med 2007; 8: 138-144. (Pubitemid 46568563)
13. Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, et al: Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 8. Cerebral perfusion pressure. Pediatr Crit Care Med 2003; 4:S31-S33.
14. Chesnut RM: The management of severe traumatic brain injury. Emerg Med Clin North Am 1997; 15: 581-604. (Pubitemid 27329926)
15. Biswas AK, Bruce DA, Sklar FH, Bokovoy JL, Sommerauer JF: Treatment of acute traumatic brain injury in children with moderate hypothermia improves intracranial hypertension. Crit Care Med 2002; 30: 2742-2751. (Pubitemid 36870578)
16. Adelson PD, Ragheb J, Kanev P, Brockmeyer D, Beers SR, Brown SD, et al: Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 2005; 56: 740-754.
17. Chambers IR, Jones PA, Lo TY, Forsyth RJ, Fulton B, Andrews PJ, et al: Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury. J Neurol Neurosurg Psychiatry 2006; 77: 234-240. (Pubitemid 43220851)
18. Jones PA, Chambers IR, Lo TY, Andrews PJ, Chaudhry W, Clark A, et al: Quantification of secondary CPP insult severity in paediatric head injured patients using a pressuretime index. Acta Neurochir Suppl 2005; 95: 29-32.
19. Ishige N, Pitts LH, Berry I, Nishimura MC, James TL: The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats. J Neurosurg 1988; 68: 129-136. (Pubitemid 18019143)
20. Clark RS, Kochanek PM, Dixon CE, Chen M, Marion DW, Heineman S, et al: Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats. J Neurotrauma 1997; 14: 179-189. (Pubitemid 27205067)
21. Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, et al: Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouse. J Neurotrauma 2007; 24: 338-353. (Pubitemid 46492155)
22. Chaiwat O, Sharma D, Udomphorn Y, Armstead WM, Vavilala MS: Cerebral hemodynamic predictors of poor 6-month Glasgow Outcome Score in severe pediatric traumatic brain injury. J Neurotrauma 2009; 26: 657-663.
23. Clifton GL, Drever P, Valadka A, Zygun D, Okonkwo D: Multicenter trial of early hypothermia in severe brain injury. J Neurotrauma 2009; 26: 393-397.
24. Brady KM, Shaffner DH, Lee JK, Easley RB, Smielewski P, Czosnyka M, et al: Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain injury in children. Pediatrics 2009; 124:e1205-e1212.