Synthesis of chroman aldehydes that inhibit HIV

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1399-1401

  Kraus, George A ^a   Mengwasser, John ^a   Maury, Wendy ^b   Oh, Choonseok ^b  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Aldehyde; Antiviral; Chroman; HIV

Indexed keywords

ACETIC ACID DERIVATIVE; ALDEHYDE DERIVATIVE; ANTIVIRUS AGENT; CHROMAN ALDEHYDE DERIVATIVE; HYDROXYL GROUP; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HELA CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50;

ALDEHYDES; ANTIVIRAL AGENTS; CELL LINE; CHROMANS; HIV; HIV INFECTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE;

EID: 79951772340     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.031     Document Type: Article

References (13)

1. R. Gambari, and I. Lampronti M.T. Hassan Khan, A. Ahter, Advances in Phytomedicine; Lead Molecules from Natural Products Vol. 2 2006 Elsevier 299
2. T. Liu, A.X. Li, Y.P. Miao, K.Z. Wu, and Y. Ma Chin. Chem. Lett 20 11 2009 1386
3. J.-H. Wu, X.-H. Wang, Y.-H. Yi, and K.-H. Lee Bioorg. Med. Chem. Lett. 13 10 2003 1813
4. W. Maury, J.P. Price, M.A. Brindley, C.S. Oh, J.D. Neighbors, D.F. Wiemer, N. Wills, S. Carpenter, C. Hauck, P. Murphy, M.P. Widrlechner, K. Delate, G. Kumar, G.A. Kraus, L. Rizshsky, and B. Nikolau Virol. J. 6 2009 101
5. G.A. Kraus, Y. Yuan, and A. Kempema Molecules 14 2 2009 807
6. G.P. Kalena, A. Jain, and A. Banerji Molecules 2 1997 100
7. W.J. Donnelly, and P.V.R. Shannon J. Chem. Soc., Perkin Trans. 1 1972 25
8. K. Nakagawa-Goto, and K.-H. Lee Tetrahedron Lett. 47 47 2006 8263
9. V.K. Ahluwalia, and R.S. Jolly Synlett 1982 74
10. E.J. Platt, K. Wehrly, S.E. Kuhmann, B. Chesebro, and D. Kabat J. Virol. 72 1998 2855
11. E. Reed-Inderbitzin, and W. Maury Virology 314 2003 680
12. V.K. Ahluwalia, K.K. Arora, and R.S. Jolly J. Chem. Soc., Perkin Trans. 1 1982 335
13. 6) δ 5.87 (s, 1H), 2.61 (s, 3H), 2.53 (t, J = 6.8 Hz, 2H), 1.78 (t, J = 6.8 Hz, 2H), 1.30 (s, 6H). The mother liquor was concentrated and the yellow residue afforded 5 as a yellow solid from benzene.