Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes

Annals of Plastic Surgery

Volumn 66, Issue 3, 2011, Pages 296-300

  Lu, Feng ^a,b   Ogawa, Rei ^a,c   Nguyen, Dinh T ^a   Chen, Bin ^a,d   Guo, Danfeng ^a,e   Helm, Douglas L ^a   Zhan, Qian ^a   Murphy, George F ^a   Orgill, Dennis P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d KUNMING MEDICAL UNIVERSITY   (China)

^e Central Hospital of Jian   (China)

Author keywords

collagen; fibroblast; fibroblast growth factor; mechanotransduction; microdeformations; myofibroblast; smooth muscle actin; transforming growth factor; Vacuum assisted closure (VAC); wound healing

Indexed keywords

ACTA2 PROTEIN, HUMAN; ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE I, ALPHA 1 CHAIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; ATMOSPHERIC PRESSURE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; UPREGULATION; VACUUM; VACUUM ASSISTED CLOSURE;

ACTINS; AIR PRESSURE; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HUMANS; NEGATIVE-PRESSURE WOUND THERAPY; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA2; UP-REGULATION; VACUUM;

EID: 79951771630     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/SAP.0b013e3181ea1e9b     Document Type: Article

References (21)

1. Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997;38: 563-576.
2. Morykwas MJ, Argenta LC, Shelton-Brown EI, et al. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38:553-562. (Pubitemid 27251299)
3. Armstrong DG, Lavery LA; Diabetic Foot Study Consortium. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366:1704-1710.
4. Saxena V, Hwang CW, Huang S, et al. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 2004;114: 1086-1096. (Pubitemid 40362027)
5. Scherer SS, Pietramaggiori G, Mathews JC, et al. The mechanism of action of the vacuum-assisted closure device. Plast Reconstr Surg. 2008;122:786-797.
6. Wilkes RP, McNulty AK, Feeley TD, et al. Bioreactor for application of subatmospheric pressure to three-dimensional cell culture. Tissue Eng. 2007; 13:3003-3010. (Pubitemid 350233075)
7. McNulty AK, Schmidt M, Feeley T, et al. Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix. Wound Repair Regen. 2007;15:838-846. (Pubitemid 350135231)
8. McNulty AK, Schmidt M, Feeley T, et al. Effects of negative pressure wound therapy on cellular energetics in fibroblasts grown in a provisional wound (fibrin) matrix. Wound Repair Regen. 2009;17:192-199.
9. Chin MS, Lancerotto L, Helm DL, et al. Analysis of neuropeptide in stretched skin. Plast Reconstr Surg. 2009;124:102-113.
10. Angele P, Yoo JU, Smith C, et al. Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro. J Orthop Res. 2003;21:451-457. (Pubitemid 36546811)
11. Elder SH, Shim JW, Borazjani A, et al. Influence of hydrostatic and distortional stress on chondroinduction. Biorheology. 2008;45:479-486.
12. Thampatty BP, Wang JH. Mechanobiology of fibroblasts. In: Kamkin AG, Kiseleva IS, eds . Mechanosensitive Ion Channels. Berlin, Germany: Springer; 2008:351.
13. Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature. 2008;453:314-321. (Pubitemid 351693137)
14. Hinz B, Celetta G, Tomasek JJ, et al. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell. 2001;12:2730-2741. (Pubitemid 33051938)
15. Kim K, Sirota A, Chen YH, et al. Dendrite-like process formation and cytoskeletal remodeling regulated by delta-catenin expression. Exp Cell Res. 2002;275:171-184. (Pubitemid 34948360)
16. Kim H, Oh M, Lu Q, et al. Cadherin negatively modulates,-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for-catenin. Biochem Biophys Res Commun. 2008;377:636-641.
17. Spurger L. Endoplasmic reticulum: structure and function. University of Texas Medical Branch. 2002. Available at: rer1.htm. Accessed September 13, 2006.
18. Wang Z, Fong KD, Phan TT, et al. Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation. J Cell Physiol. 2006;206:510-517. (Pubitemid 43062822)
19. Danciu TE, Adam RM, Naruse K, et al. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003;536:193-197. (Pubitemid 36206430)
20. Branski LK, Gauglitz GG, Herndon DN, et al. A review of gene and stem cell therapy in cutaneous wound healing. Burns. 2009;35:171-180.
21. Abe R, Donnelly SC, Peng T, et al. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol. 2001;166:7556-7562.(Pubitemid 32525636)