Investigation of breed and sex effects on cytochrome P450 gene expression in cattle liver

Research in Veterinary Science

Volumn 90, Issue 2, 2011, Pages 235-237

  Ashwell, M S ^a   Fry, R S ^a   Spears, J W ^a   O'Nan, A T ^a   Maltecca, C ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Cattle; Cytochrome P450; Gene expression; Liver

Indexed keywords

CYTOCHROME P450;

ARTICLE; CATALYSIS; CATTLE; DNA SYNTHESIS; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SEX DIFFERENCE; UPREGULATION; XENOBIOTIC METABOLISM;

ANIMALS; CATTLE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; SEX CHARACTERISTICS;

ANIMALIA; BOS;

EID: 79951771053     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2010.05.029     Document Type: Article

References (10)

1. Engle T.E., Spears J.W. Effects of dietary copper concentration and source on performance and copper status of growing and finishing steers. Journal of Animal Science 2000, 78:2446-2451.
2. Giantin M., Carletti M., Capolongo F., Pegolo S., Lopparelli R.M., Gusson F., Nebbia C., Cantiello M., Martin P., Pineau T., Dacasto M. Effect of breed upon cytochromes p450 and phase II enzyme expression in cattle liver. Drug Metabolism and Disposition 2008, 36:885-893.
3. Graham M.J., Lake B.J. Induction of drug metabolism: species differences and toxicological relevance. Toxicology 2008, 254:184-191.
4. Hansen S.L., Ashwell M.S., Legleiter L.R., Fry R.S., Lloyd K.E., Spears J.W. The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle. British Journal of Nutrition 2009, 101:1068-1078.
5. Janovick-Guretzky N.A., Dann H.M., Carlson D.B., Murphy M.R., Loor J.J., Drackley J.K. Housekeeping gene expression in bovine liver is affected by physiological state, feed intake, and dietary treatment. Journal of Dairy Science 2007, 90:2246-2252.
6. Omari A.A., Murry D.J. Pharmacogenetics of the cytochrome p450 enzyme system: review of current knowledge and clinical significance. Journal of Pharmacy Practice 2007, 20:206-218.
7. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45.
8. Pfaffl, M.W., 2009. Rest 2009 Software User Guide. Qiagen, Hilden, Germany. <>. http://www.REST.de.com.
9. Pfaffl M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002, 30:e36.
10. Waxman D.J., Holloway M.G. Centennial perspective: sex differences in the expression of hepatic drug metabolizing enzymes. Molecular Pharmacology 2009, 76:215-228.