Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

Medical Oncology

Volumn 27, Issue 4, 2010, Pages 1114-1118

  Yang, Jie ^a   Cao, Yunxin ^b   Sun, Jifeng ^a   Zhang, Yong ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2; Breast cancer; Curcumin; miR 15a; miR 16

Indexed keywords

CURCUMIN; MICRORNA; MIR 15A; MIR 16; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CURCUMIN; FEMALE; HUMANS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 79951767903     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-009-9344-3     Document Type: Article

References (20)

1. Sarkar FH, Li Y, Wang Z, Kong D, et al. Cellular signaling perturbation by natural products. Cell Signal. 2009;21:1541-7.
2. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an "old-age" disease with an "ageold" solution. Cancer Lett. 2008;267:133-64.
3. Cimmino A, Calin GA, Fabbri M, Iorio MV. miR-15 and miR-16 induce apoptosis by targeting BCL-2. Proc Natl Acad Sci U S A. 2005;102:13944-9. (Pubitemid 41377683)
4. Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, et al. Molecular mechanisms of curcumininduced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. 2003;24:1199-208. (Pubitemid 36927060)
5. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 2007;282:15954-64. (Pubitemid 47100378)
6. Garzon R, Calin GA, Croce CM. MicroRNAs in cancer. Annu Rev Med. 2009;60:167-79.
7. Wang V, Wu W. MicroRNA-based therapeutics for cancer. BioDrugs. 2009;23:15-23.
8. Davis CD, Ross SA. Evidence for dietary regulation of microR-NA expression in cancer cells. Nutr Rev. 2008;66:477-82.
9. Sun M, Estrov Z, Ji Y, Coombes KR, Harris DH, Kurzrock R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol Cancer Ther. 2008;7:464-73. (Pubitemid 351482129)
10. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132-6. (Pubitemid 27097313)
11. Youle RJ, Strasser A. The Bcl-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9:47-59.
12. Frenzel A, Grespi F, Chmelewskij W, Villunger A. Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis. 2009;14:584-96.
13. Lu Y, Xiao J, Lin H, Bai Y, Luo X, Wang Z, et al. A single antimicroRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res. 2009;37: e24.
14. Esau CC. Inhibition of microRNA with antisense oligonucleotides. Methods. 2008;44:55-60. (Pubitemid 350297990)
15. Tamvakopoulos C, Dimas K, Sofianos ZD, Hatziantoniou S, Han Z, Liu ZL, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007;13:1269-77. (Pubitemid 46424068)
16. Hammamieh R, Sumaida D, Zhang X, Das R, Jett M. Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC Cancer. 2007;7:138.
17. Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer. 2007;31:243-305. (Pubitemid 47077491)
18. Chekhun VF, Lukyanova NY, Kovalchuk O, Tryndyak VP, Pogribny IP. Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper-and hypomethylated targets. Mol Cancer Ther. 2007;6:1089-98. (Pubitemid 46554580)
19. Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F, et al. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol. 2007;9:470-8. (Pubitemid 46511081)
20. Garzon R, Pichiorri F, Palumbo T, Visentini M, Aqeilan R, Cimmino A, et al. MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene. 2007;26:4148-57. (Pubitemid 46920170)