New isoflavonoid glycosides and related constituents from astragali radix (astragalus membranaceus) and their inhibitory activity on nitric oxide production

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 4, 2011, Pages 1131-1137

  Zhang, Li Jie ^a   Liu, Hui Kang ^a   Hsiao, Ping Chun ^a,b   Kuo, Li Ming Yang ^a   Lee, I Jung ^a   Wu, Tian Shung ^c   Chiou, Wen Fei ^a   Kuo, Yao Haur ^a,c  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

astragalasides; Astragali radix; isoflavonoids; nitric oxide production

Indexed keywords

ASTRAGALASIDES; ASTRAGALI RADIX; ASTRAGALUS MEMBRANACEUS; BENZOQUINONES; CHARACTERISTIC PEAKS; EVAPORATIVE LIGHT SCATTERING DETECTORS; FINGERPRINT METHOD; HPLC-ELSD; INHIBITORY ACTIVITY; ISOFLAVONOIDS; LIPOPOLYSACCHARIDES; NATURAL PRODUCTS; SECONDARY METABOLITES;

CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; SPECTROSCOPIC ANALYSIS; SUGARS;

NITRIC OXIDE;

FLAVONOID; GLYCOSIDE; LIPOPOLYSACCHARIDE; NITRIC OXIDE;

ANIMAL; ARTICLE; ASTRAGALUS MEMBRANACEUS; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; MOUSE; PLANT ROOT;

ANIMALS; ASTRAGALUS MEMBRANACEUS; CELL LINE; FLAVONOIDS; GLYCOSIDES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PLANT ROOTS;

ASTRAGALUS MEMBRANACEUS;

EID: 79951764536     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf103610j     Document Type: Article

References (29)

1. Li, Sh. Zh. (Ming Dynasty) Ben Cao Gang Mu; National Research Institute of Chinese Medicine: Taipei, Taiwan, 1994; Vol. 3, pp 403 - 405.
2. Lau, B. H. S.; Ong, P.; Tosk, J. Macrophage chemiluminescence modulated by Chinese medicinal herbs Astragalus membranaceus and Ligustrum luidum Phytother. Res. 1989, 3, 148-153 (Pubitemid 19219595)
3. Zhao, K. S.; Mancini, C.; Doria, G. Enhancement of the immune response in mice by Astragalus membranaceus extracts Immunopharmacology 1990, 20, 225-233
4. Hong, C. Y.; Ku, J.; Wu, P. Astragalus membranaceus stimulates human sperm motility in vitro Am. J. Chinese Med. 1992, 20, 289-294
5. Jiangsu College of New Medicine. A Dictionary of Traditional Chinese Medicines; Shanghai Scientific and Technology Press: Shanghai, China, 2004; Vol. 2, pp 2036 - 2040.
6. Yesilada, E.; Bedir, E.; Çaliş, I.; Takaishic, Y.; Ohmotod, Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release J. Ethnopharmacol. 2005, 96, 71-77 (Pubitemid 39575033)
7. Yu, D. H.; Duan, Y. L.; Bao, Y. M.; Wei, C. L.; An, L. J. Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate J. Ethnopharmacol. 2005, 98, 89-94
8. Cho, W. C. S.; Leung, K. N. In vitro and in vivo anti-tumor effects of Astragalus membranaceus Cancer Lett. 2007, 252, 43-54 (Pubitemid 46734552)
9. Lee, Y. S.; Han, O. K.; Park, C. W.; Yang, C. H.; Jeon, T. W.; Yo, W. K.; Kimf, S. H.; Kim, H. J. Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264.7 macrophage cells J. Ethnopharmacol. 2005, 100, 289-294 (Pubitemid 41206623)
10. Hirotani, M.; Zhou, Y.; Lui, H.; Furuya, T. Astragalosides from hairy root cultures of Astragalus membranaceus Phytochemistry 1994, 36, 665-670 (Pubitemid 2097623)
11. Hirotani, M.; Zhou, Y.; Rui., H.; Furuya, T. Cycloartane triterpene glycosides from the hairy root cultures of Astragalus membranaceus Phytochemistry 1994, 37, 1403-1407
12. Kitagawa, I.; Wang, H. K.; Saito, M.; Tagaki, A.; Yoshikawa Saponin and sapogenol. XXXV. Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I, II, and IV, acetylastragaloside I, and isoastragalosides I, and II Chem. Pharm. Bull. 1983, 31, 698-708 (Pubitemid 13080828)
13. Bedir, E.; Calis, I.; Aquino, R.; Piacente, S.; Pizza, C. Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus J. Nat. Prod. 1998, 61, 1469-1472 (Pubitemid 29024420)
14. Lee, H. J.; Lee, O. K.; Kwon, Y. H.; Choi, D. H.; Kang, H. Y.; Lee, H. Y.; Paik, K. H.; Lee, H. J. Isoflavone glycosides from the bark of Amorpha fruticosa Chem. Nat. Compd. 2006, 42, 415-418
15. Nechepurenko, I. V.; Polovinka, M. P.; Komarova, N. I.; Korchagina, D. V.; Salakhutdinov, N. F.; Nechepurenko, S. B. Low-molecular-weight phenolic compounds from Hedysarum theinum roots Chem. Nat. Compd. 2008, 44, 31-34 (Pubitemid 351574261)
16. Tian, X. M.; Chen, S. Z.; Tang, L.; Tu, P. F. Three new isoflavonoids from the aerial parts of Ammopiptanthus mongolicus Helv. Chim. Acta 2008, 91, 1015-1022
17. 1H NMR spectra of 3′-hydroxy-4′-methoxy isoflavonoids from Astragalus membranaceus var. mongholicus Magn. Reson. Chem. 2006, 44, 708-712 (Pubitemid 44005754)
18. Pei, Y. H.; Li, R. F.; Fu, H. W.; Wang, J.; Zhou, Y. Z. A new isoflavone glucoside from Astragalus membranaceus var. mongholicus Fitoterapia 2007, 78, 602-604 (Pubitemid 47625893)
19. Li, W.; Koike, K.; Asada, Y.; Hirotani, M.; Rui, H.; Yoshikawa, T.; Nikaido, T. Flavonoids from Glycyrrhiza pallidiflora hairy root cultures Phytochemistry 2002, 60, 351-355 (Pubitemid 34619885)
20. Spencer, G. F.; Jones, B. E.; Plattner, R. D.; Barnekow, D. E.; Brinen, L. S.; Clardy, J. A pterocarpan and two isoflavans from alfalfa Phytochemistry 1991, 30, 4147-4149
21. Subarnas, A.; Oshima, Y.; Hikino, H. Isoflavans and a pterocarpan from Astragalus mongholicus Phytochemistry 1991, 30, 2777-2780
22. Kamnaing, P.; Fanso Free, S. N. Y.; Nkengfack, A. E.; Folefoc, G.; Fomum, Z. T. An isoflavan-quinone and a flavonol from Millettia laurentii Phytochemistry 1999, 51, 829-832 (Pubitemid 29289207)
23. Piccinelli, A. L.; Fernandez, M. C.; Cuesta-Rubio, O.; Hernández, I. M.; Simone, F. D.; Rastrelli, L. Isoflavonoids osolated from Cuban propolis J. Agric. Food Chem. 2005, 53, 9010-9016
24. Takahashi, M.; Fuchino, H.; Sekita, S.; Satake, M.; Kiuchi, F. Vitro leishmanicidal constituents of Millettia pendula Chem. Pharm. Bull. 2006, 54, 915-917 (Pubitemid 43824860)
25. Spencer, G. F.; Jones, B. E.; Plattner, R. D.; Barnekow, D. E.; Brinen, L. S.; Clardy, J. A pterocarpan and two isoflavans from alfalfa Phytochemistry 1991, 30, 4147-4149
26. Chiou, W. F.; Lin, J. J.; Chen, C. F. Andrographolide suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide Br. J. Pharmacol. 1998, 125, 327-334
27. Yang, D.; Cai, S.; Liu, H.; Guo, X.; Li, C.; Shang, M.; Wang, X.; Zhao, Y. On-line identification of the constituents of Buyang Huanwu decoction in pig serum using combined HPLC-DAD-MS techniques J. Chromatogr., B 2006, 831, 288-302 (Pubitemid 43155807)
28. Yu, D. Q.; Yang, J. S. Analytical Chemistry Manual (VII), Nuclear Magnetic Resonance Spectra; Chemical Industry Press: Beijing, China, 1999; Vol. 2, p 901.
29. Pachler, K.; Underwood, W. A proton magnetic resonance study of some pterocarpan derivatives. The conformation of the 6a,11a-dihydro-6 H -benzofuro[3,2- c ][1]benzopynan ring system Tetrahedron 1967, 23, 1817-1826