Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7

Annals of the New York Academy of Sciences

Volumn 1160, Issue , 2009, Pages 31-37

  Liu, Changlu ^a   Kuei, Chester ^a   Sutton, Steven ^a   Shelton, Jonathan ^a   Zhu, Jessica ^a   Nepomuceno, Diane ^a   Hossain, Mohammed Akhter ^b   Wade, John D ^b   Bathgate, Ross A D ^b   Bonaventure, Pascal ^a   Lovenberg, Timothy ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

GPCR135; GPCR142; GPR100; INSL5; LFR7; Relaxin; Relaxin 3; RXFP1; RXFP3; RXFP4

Indexed keywords

ARGINYLALANYLALANYLPROLYLTYROSYLGLYCYLVALYLARGINYLLEUCYLCYSTEINYLGLYCYLARGINYLGLUTAMYLPHENYLALANYLISOLEUCYLARGINYLALANYLVALYLISOLEUCYLPHENYLALANYLTHREONYLCYSTEINYLARGININE; CHIMERIC PROTEIN; G PROTEIN COUPLED RECEPTOR; INSULIN; RELAXIN 3; RELAXIN 3B; RELAXIN 3B INSULIN LIKE PEPTIDE 5 CONJUGATE; RELAXIN FAMILY PEPTIDE RECEPTOR 3; RELAXIN FAMLY PEPTIDE RECEPTOR 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; BODY WEIGHT; BRAIN REGION; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; FEEDING; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR AFFINITY; REGULATORY MECHANISM; STRESS;

RATTUS;

EID: 64549090037     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03790.x     Document Type: Conference Paper

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