The development of hepatoportal sclerosis and portal hypertension due to didanosine use in HIV

Virchows Archiv

Volumn 458, Issue 2, 2011, Pages 231-235

  Schiano, Thomas D ^a   Uriel, Alison ^a   Dieterich, Douglas T ^a   Fiel, M Isabel ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Antiretroviral therapy; Didanosine; Hepatoportal sclerosis; HIV; Nodular regenerative hyperplasia; Noncirrhotic portal hypertension

Indexed keywords

ABACAVIR PLUS LAMIVUDINE PLUS ZIDOVUDINE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DIDANOSINE; HEMOGLOBIN; LAMIVUDINE; NELFINAVIR; RETICULIN; SAQUINAVIR; STAVUDINE; TENOFOVIR; TENOFOVIR DISOPROXIL; VIRUS RNA; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASE REPORT; CD4 LYMPHOCYTE COUNT; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FOLLOW UP; HEPATOPORTAL SCLEROSIS; HEPATOSPLENOMEGALY; HISTOPATHOLOGY; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERNATIONAL NORMALIZED RATIO; LIPID ANALYSIS; LIVER BIOPSY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; METABOLIC SYNDROME X; MICROVASCULARIZATION; PORTAL HYPERTENSION; PRIORITY JOURNAL; REAGIN TEST; SCLEROSIS; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT DURATION;

ANTI-HIV AGENTS; DIDANOSINE; HIV INFECTIONS; HUMANS; HYPERTENSION, PORTAL; LIVER; MALE; MIDDLE AGED; PORTAL SYSTEM; SCLEROSIS;

EID: 79951726145     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-010-1004-7     Document Type: Article

References (25)

1. P Bioulac-Sage B Le Bail PH Bernard C Balabaud 1995 Hepatoportal sclerosis Semin Liver Dis 15 329 339 1:STN:280:DyaK287lsl2rsA%3D%3D 10.1055/s-2007-1007285 8578318
2. SK Sarin A Kumar YK Chawla, et al. 2007 Noncirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment Hepatol Int 1 398 413 10.1007/s12072-007-9010-9 19669336
3. PA Reshamwala DE Kleiner T Heller 2006 Nodular regenerative hyperplasia: not all nodules are c (Pubitemid 44049133)
4. TD Schiano DP Kotler E Ferran MI Fiel 2007 Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV Am J Gastroenterol 102 2536 2540 10.1111/j.1572-0241.2007.01428.x 17640321 (Pubitemid 47631766)
5. V Mallet P Blanchard V Verkarre, et al. 2007 Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients AIDS 21 187 192 10.1097/QAD.0b013e3280119e47 17197809 (Pubitemid 46036926)
6. I Maida M Nunez MJ Rios, et al. 2006 Severe liver disease associated with prolonged exposure to antiretroviral drugs J Acquir Immune Defic Syndr 42 177 182 1:CAS:528:DC%2BD28XltlKqs7Y%3D 10.1097/01.qai.0000221683.44940.62 16688096 (Pubitemid 43884712)
7. I Maida P Garcia-Gasco G Sotgiu, et al. 2008 Antiretroviral-associated portal hypertension: a new clinical condition? Prevalence, predictors and outcome Antivir Ther 13 103 107 18389904 (Pubitemid 351541679)
8. S Saifee D Joelson J Braude, et al. 2008 Noncirrhotic portal hypertension in patients with human immunodeficiency virus-1 infection Clin Gastroenterol Hepatol 6 1167 1169 1:CAS:528:DC%2BD1cXhtlSgtL3K 10.1016/j.cgh.2008.04.023 18639498
9. PE Chang R Miquel JL Blanco, et al. 2009 Idiopathic portal hypertension in patients with HIV infection treated with highly active antiretroviral therapy Am J Gastroenterol 104 1707 1714 1:CAS:528:DC%2BD1MXotVKjurc%3D 10.1038/ajg.2009.165 19471257
10. H Kovari B Ledergerber U Peter, et al. 2009 Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study Clin Infect Dis 49 626 635 1:CAS:528:DC%2BD1MXhtVOmsrzL 10.1086/603559 19589079
11. SA Geller MC Dubinsky FF Poordad, et al. 2004 Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease Am J Surg Pathol 28 1204 1211 10.1097/01.pas. 0000128665.12063.97 15316320 (Pubitemid 39121614)
12. R De Bruyne B Portmann M Samyn, et al. 2006 Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia J Hepatol 44 407 410 10.1016/j.jhep.2005.06.020 16226335 (Pubitemid 43069224)
13. DA Katzka SH Saul D Jorkasky H Sigal JC Reynolds RD Soloway 1986 Azathioprine and hepatic venocclusive disease in renal transplant patients Gastroenterology 90 446 454 1:STN:280:DyaL28%2FotlSgtw%3D%3D 3510146 (Pubitemid 16136691)
14. I Kochin M Magid R Arnon A Glasscock N Kerkar T Miloh 2010 Variceal bleeding in an adolescent with HIV diagnosed with hepatoportal sclerosis and nodular regenerative hyperplasia J Pediatr Gastroenterol Nutr 50 340 343 10.1097/MPG.0b013e3181a70f63 19841596
15. J Ludwig E Hashimoto H Obata WP Baldus 1993 Idiopathic portal hypertension; a histopathological study of 26 Japanese cases Histopathology 22 227 234 1:STN:280:DyaK3s3ms1aluw%3D%3D 10.1111/j.1365-2559.1993.tb00112.x 8495956 (Pubitemid 23105131)
16. S Hillaire E Bonte MH Denninger, et al. 2002 Idiopathic non-cirrhotic intrahepatic portal hypertension in the West: a re-evaluation in 28 patients Gut 51 275 280 1:STN:280:DC%2BD38zpslSksg%3D%3D 10.1136/gut.51.2.275 12117894 (Pubitemid 34791461)
17. M Okudaira M Ohbu K Okuda 2002 Idiopathic portal hypertension and its pathology Semin Liver Dis 22 59 72 10.1055/s-2002-23207 11928079
18. N Crum-Cianflone A Dilay G Collins, et al. 2009 Nonalcoholic fatty liver disease among HIV-infected persons J Acquir Immune Defic Syndr 50 464 473 10.1097/QAI.0b013e318198a88a 19225402
19. B Geramizadeh SA Malek-Hosseini H Salahi A Bahador S Nikeghbalian 2008 Liver failure and the need for transplantation in three patients with hepatoportal sclerosis Transplant Proc 40 3526 3528 1:STN:280: DC%2BD1M%2Fkt12rtw%3D%3D 10.1016/j.transproceed.2008.06.104 19100429
20. M Isabel Fiel SN Thung P Hytiroglou S Emre TD Schiano 2007 Liver failure and need for liver transplantation in patients with advanced hepatoportal sclerosis Am J Surg Pathol 31 607 614 1:STN:280:DC%2BD2s3ivVSgsQ%3D%3D 10.1097/01.pas.0000213425.76621.f1 17414109 (Pubitemid 46569046)
21. AM Krasinskas B Eghtesad PS Kamath AJ Demetris SC Abraham 2005 Liver transplantation for severe intrahepatic noncirrhotic portal hypertension Liver Transpl 11 627 634 10.1002/lt.20431 15915493 (Pubitemid 40872900)
22. SA Gonzalez AH Talal 2003 Hepatitis C virus in human immunodeficiency virus-infected individuals: an emerging comorbidity with significant implications Semin Liver Dis 23 149 166 10.1055/s-2003-39946 12800068 (Pubitemid 36666684)
23. E Marine-Barjoan MC Saint-Paul C Pradier, et al. 2004 Impact of antiretroviral treatment on progression of hepatic fibrosis in HIV/hepatitis C virus co-infected patients AIDS 18 2163 2170 10.1097/00002030-200411050-00008 15577649 (Pubitemid 39463681)
24. N Brau M Salvatore CF Rios-Bedoya, et al. 2006 Slower fibrosis progression in HIV/HCV-coinfected patients with successful HIV suppression using antiretroviral therapy J Hepatol 44 47 55 10.1016/j.jhep.2005.07.006 16182404 (Pubitemid 41772515)
25. VO Mallet A Varthaman D Lasne, et al. 2009 Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients AIDS 23 1511 1518 1:CAS:528: DC%2BD1MXovVSgs7s%3D 10.1097/QAD.0b013e32832bfa51 19512859