Innate immunity in DNA vaccine with Toxoplasma gondii-heat shock protein 70 gene that induces DC activation and Th1 polarization

Vaccine

Volumn 29, Issue 10, 2011, Pages 1899-1905

  Makino, Masayuki ^a   Uemura, Noriko ^a   Moroda, Masataka ^a   Kikumura, Akitoshi ^a   Piao, Lian Xun ^a,b   Mohamed, Rabie M ^a,c   Aosai, Fumie ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b YANBIAN UNIVERSITY   (China)

^c Minia University   (Egypt)

Author keywords

DC vaccine; HSP70; T.g.HSP70 gene vaccine; Th1 polarization; Toxoplasma gondii

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOXOPLASMA GONDII HEAT SHOCK PROTEIN 70 VACCINE; TOXOPLASMA GONDII VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; FEMALE; GENE; IN VIVO STUDY; INNATE IMMUNITY; LYMPH NODE; MOUSE; NONHUMAN; PLASMID; POLARIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH1 CELL; TOXOPLASMOSIS; VACCINATION; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION PROFILING; HSP70 HEAT-SHOCK PROTEINS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; LYMPH NODES; MICE; MICE, INBRED C57BL; PLASMIDS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; RNA, MESSENGER; TH1 CELLS; TOXOPLASMA; VACCINES, DNA;

EID: 79951723222     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.12.118     Document Type: Article

References (46)

1. Yano A., Mun H.S., Chen M., Norose K., Hata H., Kobayashi M., et al. Roles of IFN-γ on stage conversion of an obligate intracellular protozoan parasite, Toxoplasma gondii. Int Rev Immunol 2002, 21:405-421.
2. Schaap D., Vermeulen A.N., Roberts C.W., Alexander J. Vaccination against toxoplasmosis: current status and future prospects. Toxoplasma gondii, The model apicomplexan: perspectives and methods 2007, 721-747. Academic Press, Elsevier, London, UK. L.M. Weiss, K. Kim (Eds.).
3. Mohamed R.M., Aosai F., Chen M., Mun H.S., Norose K., Belal U.S., et al. Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. Vaccine 2003, 21:2852-2861.
4. Mun H.S., Aosai F., Norose K., Chen M., Hata H., Tagawa Y., et al. Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice. Cell Stress Chaperones 2000, 5:328-335.
5. Fang H., Aosai F., Mun H.S., Norose K., Ahmed A.K., Furuya M., et al. Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. Int Immunol 2006, 18:1487-1497.
6. Fang H., Mun H.S., Kikumura A., Sayama Y., Norose K., Yano A., et al. Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. Microbiol Immunol 2008, 52:366-374.
7. Kikumura A., Fang H., Mun H.S., Uemura N., Makino M., Sayama Y., et al. Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene. Parasitol Int 2010, 59:105-111.
8. Chen M., Aosai F., Mun H.S., Norose K., Hata H., Yano A. Anti-HSP70 autoantibody formation by B-1 cells in Toxoplasma gondii-infected mice. Infect Immun 2000, 68:4893-4899.
9. Chen M., Aosai F., Norose K., Mun H.S., Yano A. The role of anti-HSP70 autoantibody-forming VH1-JH1 B-1 cells in Toxoplasma gondii-infected mice. Int Immunol 2003, 15:39-47.
10. Mun H.S., Aosai F., Fang H., Piao L.X., Winn T., Norose K., et al. A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection. Microbiol Immunol 2005, 49:853-858.
11. Aosai F., Chen M., Kang H.K., Mun H.S., Norose K., Piao L.X., et al. Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen. Cell Stress Chaperones 2002, 7:357-364.
12. Kang H.K., Lee H.Y., Lee Y.N., Jo E.J., Kim J.I., Aosai F., et al. Toxoplasma gondii-derived heat shock protein 70 stimulates the maturation of human monocyte-derived dendritic cells. Biochem Biophys Res Commun 2004, 322:899-904.
13. Aosai F., Rodriguez Pena M.S., Mun H.S., Fang H., Mitsunaga T., Norose K., et al. Toxoplasma gondii-derived heat shock protein 70 stimulates maturation of murine bone marrow-derived dendritic cells via Toll-like receptor 4. Cell Stress Chaperones 2006, 11:13-22.
14. Mun H.S., Aosai F., Yano A. Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii. Microbiol Immunol 1999, 43:471-479.
15. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1988, 392:245-252.
16. Leitner W.W., Seguin M.C., Ballou W.R., Seitz J.P., Schultz A.M., Sheehy M.J., et al. Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites. J Immunol 1997, 159:6112-6119.
17. Yoshida A., Nagata T., Uchijima M., Higashi T., Koide Y. Advantage of gene gunmediated over intramuscular inoculation of plasmid DNA vaccine in reproducible induction of specific immune responses. Vaccine 2000, 18:1725-1729.
18. Huang B., Mao C.P., Peng S., He L., Hung C.F., Wu T.C. Intradermal administration of DNA vaccines combining a strategy to bypass antigen processing with a strategy to prolong dendritic cell survival enhances DNA vaccine potency. Vaccine 2007, 25:7824-7831.
19. Aosai F., Sayama Y., Uemura N., Kikumura A., Akira S. Innate immunity in Toxoplasma gondii heat shock protein 70-stimulated dendritic cell maturation and Th1 polarization. Curr Res Immunol 2009, 3:1-15.
20. Chen M., Aosai F., Norose K., Mun H.S., Takeuchi O., Akira S., et al. Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice. J Parasitol 2002, 88:1017-1019.
21. Mun H.S., Aosai F., Norose K., Chen M., Piao L.X., Takeuchi O., et al. TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int Immunol 2003, 15:1081-1087.
22. Kudo M., Aosai F., Mun H.S., Norose K., Akira S., Iwakura Y., et al. The role of IFN-γ and Toll-like receptors in nephropathy induced by Toxoplasma gondii infection. Microbiol Immunol 2004, 48:617-628.
23. Mun H.S., Aosai F., Norose K., Piao L.X., Fang H., Akira S., et al. Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. Infect Immun 2005, 73:4634-4642.
24. Luo W., Aosai F., Ueda M., Yamashita K., Shimizu K., Sekiya S., et al. Kinetics in parasite abundance in susceptible and resistant mice infected with an avirulent strain of Toxoplasma gondii by using quantitative competitive PCR. J Parasitol 1997, 83:1070-1074.
25. Norose K., Mun H.S., Aosai F., Chen M., Hata H., Tagawa Y., et al. Organ infectivity of Toxoplasma gondii in IFN-γ knockout mice. J Parasitol 2001, 87:447-452.
26. Saito S., Aosai F., Rikihisa N., Mun H.S., Norose K., Chen M., et al. Establishment of gene-vaccinated skin grafting against Toxoplasma gondii infection in mice. Vaccine 2001, 19:2172-2180.
27. Akira S., Takeda K. Toll-like receptor signaling. Nat Rev Immunol 2004, 4:499-511.
28. Scanga C.A., Aliverti J., Jankovic D., Tilloy F., Bennouna S., Denkers E.Y., et al. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol 2002, 168:5997-6001.
29. Johnson L.L., Sayles P.C. Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii. J Exp Med 1997, 186:1799-1802.
30. Gazzinelli R.T., Wysocka M., Hayashi S., Denkers E.Y., Hieny S., Caspar P., et al. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994, 153:2533-2543.
31. Aliberti J., Jankovic D., Sher A. Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection. Immunol Rev 2004, 201:26-34.
32. Garg S., Oran A., Wajchman J., Sasaki S., Maris C.H., Kapp J.A., et al. Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo. Nat Immunol 2003, 4:907-912.
33. Porgador A., Irvine K.R., Iwasaki A., Barber B.H., Restifo N.P., Germain R.N. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med 1998, 188:1075-1082.
34. Condon C., Watkins S.C., Celluzzi C.M., Thompson K., Falo L.D. DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 1996, 2:1122-1128.
35. Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., et al. Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002, 277:15028-15034.
36. Vabulas R.M., Ahmad-Nejad P., Ghose S., Kirschning C.J., Issels R.D., Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 2002, 277:15107-15112.
37. LaRosa D.F., Stumhofer J.S., Gelman A.E., Rahman A.H., Taylor D.K., Hunter C.A., et al. T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A 2008, 105:3855-3860.
38. Suzuki Y., Orellana M.A., Schreiber R.D., Remington J.S. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 1988, 240:516-518.
39. Yang T.H., Aosai F., Norose K., Ueda M., Yano A. Enhanced cytotoxicity of IFN-gamma-producing CD4+ cytotoxic T lymphocytes specific for T. gondii-infected human melanoma cells. J Immunol 1995, 154:290-298.
40. Aosai F., Yang T.H., Ueda M., Yano A. Isolation of naturally processed peptides from a Toxoplasma gondii-infected human B lymphoma cell line that are recognized by cytotoxic T lymphocytes. J Parasitol 1994, 80:260-266.
41. Hunter C.A., Subauste C.S., Van Cleave V.H., Remington J.S. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect Immun 1994, 62:2818-2824.
42. Gazzinelli R.T., Hakim F.T., Hieny S., Shearer G.M., Sher A. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 1991, 146:286-292.
43. Remington J.S., McLeod R., Thulliez P., Desmonts G. Toxoplasmosis. Infectious diseases of the fetus and newborn infant 2006, 948-1092. Elsevier Saunders, [chapter 31]. sixth edition. J.S. Remington, J.O. Klein, C.B. Wilson, C.J. Baker (Eds.).
44. Johnson L.L., Sayles P.C. Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice. Infect Immun 2002, 70:185-191.
45. Casciotti L., Ely K.H., Williams M.E., Khan I.A. CD8 (+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4 (+) T cells. Infect Immun 2002, 70:434-443.
46. Yang T.H., Aosai F., Norose K., Mun H.S., Yano A. Heat shock cognate protein 71-associated peptides function as an epitope for Toxoplasma gondii-specific CD4+ CTL. Microbiol Immunol 1997, 41:553-561.