Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1519-1522

  Rasmussen, Tina S ^a   Allman, Sarah ^b   Twigg, Gabriele ^b   Butters, Terry D ^b   Jensen, Henrik H ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Chaperone; Glucocerebrosidase; Inhibition; Nortropane

Indexed keywords

CALYSTEGINE B2; CHAPERONE; GLUCOSYLCERAMIDASE; GLYCOSIDASE INHIBITOR; ISOFAGOMINE; MUTANT PROTEIN; N BUTYL NOEUROSTEGINE; N NONYL NOEUROSTEGINE; NOEUROSTEGINE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GAUCHER DISEASE; HUMAN; HUMAN CELL; IC 50; LYMPHOBLAST;

ENZYME ASSAYS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; INHIBITORY CONCENTRATION 50; NORTROPANES;

EID: 79951722986     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.106     Document Type: Article

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