Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1366-1370

  Park, Woul Seong ^a   Kang, Seung Kyu ^a   Jun, Mi Ae ^a   Shin, Mi Sik ^a   Kim, Ki Young ^a   Rhee, Sang Dal ^a   Bae, Myung Ae ^a   Kim, Min Sun ^a   Kim, Kwang Rok ^a   Kang, Nam Sook ^a   Yoo, Sung Eun ^a   Lee, Jie Oh ^b   Song, Dong Hyun ^b   Silinski, Peter ^c   Schneider, Stephen Edward ^c   Ahn, Jin Hee ^a   Kim, Sung Soo ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Kainos Medicine USA Inc   (United States)

Author keywords

Diabetes; DPP IV; Thiazolidine; Treatment

Indexed keywords

BETA AMINOACYL THIAZOLIDINE; CYTOCHROME; DIPEPTIDYL PEPTIDASE 2; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE 9; DIPEPTIDYL PEPTIDASE IV INHIBITOR; SITAGLIPTIN; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE MODELS, ANIMAL; DOGS; ENZYME ACTIVATION; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RATS; THIAZOLIDINES;

CANIS FAMILIARIS; RATTUS;

EID: 79951722945     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.041     Document Type: Article

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