Synthesis and biological activity of novel MIF antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1508-1511

  Balachandran, Sarala ^a   Gadekar, Pradip K ^a   Parkale, Santosh ^a   Yadav, Vitthal N ^a   Kamath, Divya ^a   Ramaswamy, Sneha ^a   Sharma, Somesh ^a   Vishwakarma, Ram A ^a   Dagia, Nilesh M ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Cytokines; Furan; Indole; Inflammation; MIF

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR ANTAGONIST; ENZYME INHIBITOR; FURAN DERIVATIVE; INDOLE DERIVATIVE; ISO 1; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN SECRETION;

ENZYME ACTIVATION; ENZYME INHIBITORS; FURANS; HUMANS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MOLECULAR STRUCTURE;

EID: 79951721202     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.127     Document Type: Article

References (11)

1. J.A. Baugh, and R. Bucala Crit. Care Med. 30 2002 S27
2. E.F. Morand, M. Leech, and J. Bernhagen Nat. Rev. Drug Disc. 5 2006 399
3. Y. Al-Abed, D. Dabideen, B. Aljabari, A. Valster, D. Messmer, M. Ochani, M. Tanovic, K. Ochani, M. Bacher, F. Nicoletti, C. Metz, V.A. Pavlov, E.J. Miller, and K.J. Tracey J. Biol. Chem. 280 2005 36541
4. D.R. Dabideen, K.F. Cheng, B. Aljabari, E.J. Miller, V.A. Pavlov, and Y. Al-Abed J. Med. Chem. 50 2007 1993
5. N.M. Dagia, D.V. Kamath, P. Bhatt, R.D. Gupte, S.S. Dadarkar, L. Fonseca, G. Agarwal, A. Chetrapal-Kunwar, S. Balachandran, S. Srinivasan, J. Bose, K. Pari, C. B-Rao, S.S. Parkale, P.K. Gadekar, A.H. Rodge, N. Mandrekar, R.A. Vishwakarma, and S. Sharma Eur. J. Pharmacol. 607 2009 201
6. S. Balachandran, A. Rodge, P.K. Gadekar, V.N. Yadav, D. Kamath, A. Chetrapal-Kunwar, P. Bhatt, S. Srinivasan, S. Sharma, R.A. Vishwakarma, and N.M. Dagia Bioorg. Med. Chem. Lett. 19 2009 4773
7. G. Fingerle-Rowson, D.R. Kaleswarapu, C. Schlander, N. Kabgani, T. Brocks, N. Reinart, R. Busch, A. Schütz, H. Lue, X. Du, A. Liu, H. Xiong, Y. Chen, A. Nemajerova, M. Hallek, J. Bernhagen, L. Leng, and R. Bucala Mol. Cell. Biol. 29 2009 1922
8. Gaeta, F. C. A.; Baird, A.; Anchin, J.; Ying, W.; Florkiewicz, R.; Sircar, J.; Sunilkumar, K. C. Avanir Pharmaceuticals, USA 2006, US7,129,236B2.
9. X. Zhang, and R. Bucala Bioorg. Med. Chem. Lett. 9 1999 3193
10. V. Schwartz, H. Lue, S. Kraemer, J. Korbiel, R. Krohn, K. Ohl, R. Bucala, C. Weber, and J. Bernhagen FEBS Lett. 583 2009 2749
11. P.D. Senter, Y. Al-Abed, C.N. Metz, F. Benigni, R.A. Mitchell, J. Chesney, J. Han, C.G. Gartner, S.D. Nelson, G.J. Todaro, and R. Bucala Proc. Natl. Acad. Sci. U.S.A. 99 2002 144