The influence of HLA-DRB1 alleles and rheumatoid factor on disease outcome in an inception cohort of patients with early inflammatory arthritis

Arthritis and Rheumatism

Volumn 42, Issue 10, 1999, Pages 2174-2183

  Harrison, Beverley ^a   Thomson, Wendy ^a   Symmons, Deborah ^a   Ollier, Bill ^a   Wiles, Nicola ^a   Payton, Tony ^a   Barrett, Elizabeth ^a   Silman, Alan ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DR ANTIGEN; RHEUMATOID FACTOR;

ADOLESCENT; ADULT; AGED; ALLELISM; ARTICLE; DISABILITY; DISEASE COURSE; FEMALE; GENETIC SCREENING; HUMAN; JOINT RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; ARTHRITIS, RHEUMATOID; COHORT STUDIES; FEMALE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; PROGNOSIS;

EID: 0033508987     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199910)42:10<2174::AID-ANR19>3.0.CO;2-G     Document Type: Article

References (61)

1. Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978;298:869-71.
2. Ollier W, Thomson W. Population genetics of rheumatoid arthritis. Rheum Dis Clin North Am 1992;18:741-59.
3. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30: 1205-13.
4. Thomson W, Pepper L, Payton A, Carthy D, Scott D, Ollier W, et al. Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community. Ann Rheum Dis 1993;52:539-41.
5. De Jongh BM, van Romunde LKJ, Valkenburg HA, De Lange GG. Epidemiological study of HLA and GM in rheumatoid arthritis and related symptoms in an open Dutch population. Ann Rheum Dis 1984;43:613-9.
6. Eberhardt KB, Fex E. Functional impairment and disability in early rheumatoid arthritis - development over 5 years. J Rheumatol 1995;22:1037-42.
7. Young A. Short-term outcomes in recent-onset rheumatoid arthritis. Br J Rheumatol 1995;34 Suppl 2:79-86.
8. Feigenbaum SL, Masi AT, Kaplan SB. Prognosis in rheumatoid arthritis: a longitudinal study of newly diagnosed younger adult patients. Am J Med 1979;66:377-84.
9. Kaarela K. Prognostic factors and diagnostic criteria in early rheumatoid arthritis. Scand J Rheumatol 1985;57 Suppl;1-54.
10. Corbett M, Dalton S, Young A, Silman A, Shipley M. Factors predicting death, survival and functional outcome in a prospective study of early rheumatoid disease over fifteen years. Br J Rheumatol 1993;32:717-23.
11. Van der Heijde DMFM, van Riel PLCM, van Leeuwen MA, van't Hof MA, van Rijswijk MH, van de Putte LBA. Prognostic factors for radiographic damage and physical disability in early rheumatoid arthritis: a prospective follow-up study of 147 patients. Br J Rheumatol 1992;31:519-25.
12. Van der Heide A, Jacobs JWG, Haanen HCM, Bijlsma JWJ. Is it possible to predict the first year extent of pain and disability for patients with rheumatoid arthritis? J Rheumatol 1995;22:1466-70.
13. Devlin J, Gough A, Huissoon A, Perkins P, Holder R, Reece R, et al. The acute phase and function in early rheumatoid arthritis: C-reactive protein levels correlate with functional outcome. J Rheumatol 1997;24:9-13.
14. Young A, Bielawska C, Corbett M, Roitt I. A prospective study of early onset rheumatoid arthritis over 15 years: prognostic features and outcome. Clin Rheumatol 1987;6 Suppl 2:12-9.
15. Van Leeuwen MA, Westra J, van Riel PLCM, Limburg PC, van Rijswijk MH. IgM, IgA and IgG rheumatoid factors in early rheumatoid arthritis: predictive of radiological progression? Scand J Rheumatol 1995;24:146-53.
16. Van Zeben D, Hazes JMW, Zwinderman AH, Cats A, Schreuder GMT, D'Amaro J, et al. Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis: results of a followup study. Arthritis Rheum 1991;34:822-30.
17. Emery P, Salmon M, Bradley H, Wordsworth P, Tunn E, Bacon PA, et al. Genetically determined factors as predictors of radiological changes in patients with early symmetrical arthritis. BMJ 1992;305:1387-9.
18. Paimela L, Leirisalo-Repo M, Helve T, Koskimies S. The prognostic value of HLA DR4 and B27 antigens in early rheumatoid arthritis. Scand J Rheumatol 1993;22:220-4.
19. Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D, et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994;37:1166-70.
20. Suarez-Almazor ME, Tao S, Moustarah F, Russell AS, Maksymowych W. HLA-DR1, DR4, and DRB1 disease related subtypes in rheumatoid arthritis: association with susceptibility but not severity in a city wide community based study. J Rheumatol 1995;22:2027-33.
21. Eberhardt K, Fex E, Johnson U, Wollheim FA. Associations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis. Ann Rheum Dis 1996;55:34-9.
22. Higami K, Hakoda M, Matsuda Y, Ueda H, Kashiwazaki S. Lack of association of HLA-DRB1 genotype with radiologie progression in Japanese patients with early rheumatoid arthritis. Arthritis Rheum 1997;40:2241-7.
23. Wagner U, Kaltenhäuser S, Sauer H, Arnold S, Seidel W, Häntzschel H, et al. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum 1997;40: 341-51.
24. Plant MJ, Jones PW, Saklatvala J, Ollier WER, Dawes P. Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. J Rheumatol 1998;25:417-26.
25. Silman AJ, Reeback J, Jaraquemada D. HLA-DR4 as a predictor of outcome three years after onset of rheumatoid arthritis. Rheumatol Int 1986;6:233-5.
26. Van Jaarsveld CHM, Otten HG, Jacobs JWG, Kruize AA, Brus HLM, Bijlsma JWJ. Association of HLA-DR with susceptibility to and clinical expression of rheumatoid arthritis: re-evaluation by means of genomic tissue typing. Br J Rheumatol 1998;37:411-6.
27. Salmon M, Wordsworth P, Emery P, Tunn E, Bacon PA, Bell JI. The association of HLA DR B alleles with self-limiting and persistent forms of early symmetrical polyarthritis. Br J Rheumatol 1993;32:628-30.
28. Möttönen T, Paimela L, Leirisalo-Repo M, Kautiainen H, Ilonen J, Hannonen P. Only high disease activity and positive rheumatoid factor indicate poor prognosis in patients with early rheumatoid arthritis treated with 'sawtooth' strategy. Ann Rheum Dis 1998; 57:533-9.
29. Symmons DPM, Barrett EM, Bankhead CR, Scott DGI, Silman AJ. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol 1994;33:735-9.
30. Thomson W, Harrison B, Ollier B, Wiles N, Payton T, Barrett J, et al. Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study. Arthritis Rheum 1999;42:757-62.
31. Harrison BJ, Symmons DPM, Brennan P, Bankhead CR, Barrett EM, Scott DGI, et al. Inflammatory polyarthritis in the community is not a benign disease: predicting functional disability one year after presentation. J Rheumatol 1996;23:1326-31.
32. Harrison BJ, Symmons DPM, Brennan P, Barrett EM, Silman AJ. Natural remission in inflammatory polyarthritis: issues of definition and prediction. Br J Rheumatol 1996;35:1096-100.
33. Brennan P, Harrison B, Barrett E, Chakravarty K, Scott D, Silman A, et al. A simple algorithm to predict the development of radiological erosions in patients with early rheumatoid arthritis: prospective cohort study. BMJ 1996;313:471-6.
34. Fries JF, Spitz PW, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis Rheum 1980;23:137-45.
35. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
36. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol 1977;18:481-91.
37. Wordsworth P, Pile KD, Buckley JD, Lanchbury JS, Ollier B, Lathrop M, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992;51:585-91.
38. Harrison BJ, Symmons DPM, Barrett EM, Silman AJ. The performance of the 1987 ARA classification criteria for rheumatoid arthritis in a population based cohort of patients with early inflammatory polyarthritis. J Rheumatol 1998;25:2324-30.
39. Harrison BJ. Determinants of outcome at 3 years in a primary care based cohort of patients with early inflammatory polyarthritis [thesis]. Manchester (UK): Univ. of Manchester; 1998.
40. Young A, Jaraquemada D, Awad J, Festenstein H, Corbett M, Hay FC, et al. Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologie changes in a prospective study of patients with rheumatoid arthritis: preferential relationship with HLA-Dw rather than HLA-DR specificities. Arthritis Rheum 1984;27:20-5.
41. Eberhardt K, Grubb R, Johnson U, Pettersson H. HLA-DR antigens, Gm allotypes and antiallotypes in early rheumatoid arthritis - their relation to disease progression. J Rheumatol 1993; 20:1825-9.
42. Seidl C, Koch U, Buhleier T, Frank R, Möller B, Markert E, et al. HLA-DRB1*04 subtypes are associated with increased inflammatory activity in early rheumatoid arthritis. Br J Rheumatol 1997; 36:941-4.
43. Pinals RS, Masi AT, Larsen RA, and the Subcommittee for Criteria of Remission in Rheumatoid Arthritis of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum 1981;24:1308-15.
44. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
45. Hall FC, Weeks DE, Camilleri JP, Williams LA, Amos N, Darke C, et al. Influence of the HLA-DRB1 locus on susceptibility and severity of rheumatoid arthritis. QJM 1996;89:821-9.
46. Weyand CM, Goronzy JJ. Correlation between HLA-DR sequence polymorphisms and rheumatoid factor production. Ann N Y Acad Sci 1997;815:353-6.
47. MacGregor AJ, Ollier WER, Venkovsky J, Mageed RA, Carthy D, Silman AJ. Rheumatoid factor isotypes in monozygotic and dizygotic twins discordant for rheumatoid arthritis. J Rheumatol 1995;22:2203-7.
48. Gran JT, Husby G. Seronegative rheumatoid arthritis and HLA-DR4: proposal for criteria. J Rheumatol 1987;14:1079-82.
49. Vehe RK, Nepom GT, Wilske KR, Stage D, Begovich AB, Nepom BS. Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. J Rheumatol 1994;21: 194-6.
50. Hajeer AH, Worthington J, Silman AJ, Ollier WER. Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 1996;39:1109-14.
51. Brinkman RMN, Huizinga TWJ, Kurban SS, van der Velde EA, Schreuder GMT, Hazes JMW, et al. Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 1997;36: 516-21.
52. Jaraquemada D, Ollier W, Awad J, Young A, Festenstein H. HLA and rheumatoid arthritis: susceptibility or severity? Dis Markers 1986;4:43-53.
53. Stockman A, Emery P, Doyle T, Hopper J, Tait B, Muirden K. Relationship of progression of radiographic changes in hands and wrists, clinical features and HLA-DR antigens in rheumatoid arthritis. J Rheumatol 1991;18:1001-7.
54. Egsmose C, Lund B, Borg G, Pettersson H, Berg E, Brodin U, et al. Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5 year followup of a prospective double blind placebo controlled study. J Rheumatol 1995;22:2208-13.
55. Van der Heide A, Jacobs JWG, Bijlsma JWJ, Heurkens AHM, van Booma-Frankfort C, van der Veen MJ, et al. The effectiveness of early treatment with "second line" antirheumatic drugs, a randomised controlled trial. Ann Intern Med 1996;124:699-707.
56. Emery P, Salmon M. Early rheumatoid arthritis: time to aim for remission? Ann Rheum Dis 1995;54:944-7.
57. Symmons DPM, Ollier WER, Brennan P, Silman AJ. Should patients with recent onset rheumatoid arthritis be offered genetic screening? Ann Rheum Dis 1996;55:407-10.
58. Nepom GT, Gersuk V, Nepom BS. Prognostic implications of HLA genotyping in the early assessment of patients with rheumatoid arthritis. J Rheumatol 1996;23 Suppl 44:5-9.
59. Van Jaarsveld CHM, Otten HG, Jacobs JWG, Kruize AA, Brus HLM, Bijlsma JWJ. Is there an indication for HLA-DR typing for individual patients with rheumatoid arthritis? Clin Exp Rheumatol 1998;16:483-8.
60. Van der Heijde DMFM, van Leeuwen MA, van Riel PLCM, Koster AM, van 't Hof MA, van Rijswijk MH, et al. Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis. Arthritis Rheum 1992;35:26-34.
61. Nelson JL, Dugowson CE, Koepsell TD, Voigt LF, Branchaud AM, Barrington RA, et al. Rheumatoid factor, HLA-DR4, and allelic variants of DRB1 in women with recent-onset rheumatoid arthritis. Arthritis Rheum 1994;37:673-80.