Differential expression of tartrate-resistant acid phosphatase isoforms 5a and 5b by tumor and stromal cells in human metastatic bone disease

Clinical and Experimental Metastasis

Volumn 28, Issue 1, 2011, Pages 65-73

  Zenger, Serhan ^a   He, Wentao ^a   Ek Rylander, Barbro ^a   Vassiliou, Daphne ^a   Wedin, Rickard ^b   Bauer, Henrik ^b   Andersson, Göran ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bone resorption; Cancer; Macrophage; Metastatic bone disease; Osteoclast; Tartrate resistant acid phosphatase

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME 5A; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME 5B; ISOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMICAL COMPOSITION; BIOCHEMISTRY; BONE METASTASIS; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GIANT CELL; HUMAN; HUMAN TISSUE; IC 50; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY CANCER; LUNG; MALE; PROSTATE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SENSITIVITY ANALYSIS; STROMA CELL; TUMOR CELL;

ACID PHOSPHATASE; BONE NEOPLASMS; BREAST NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; STROMAL CELLS;

EID: 79951675833     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-010-9358-4     Document Type: Article

References (53)

1. Clark PE, Torti FM (2003) Prostate cancer and bone metastases: medical treatment. Clin Orthop Relat Res: S148-157 (Pubitemid 37323332)
2. Roodman GD (2004) Mechanisms of bone metastasis. N Engl J Med 350:1655-1664
3. El-Tanani MK (2008) Role of osteopontin in cellular signaling and metastatic phenotype. Front Biosci 13:4276-4284 (Pubitemid 351599683)
4. Hayman AR, Bune AJ, Bradley JR, Rashbass J, Cox TM (2000) Osteoclastic tartrate-resistant acid phosphatase (Acp 5): its localization to dendritic cells and diverse murine tissues. J Histochem Cytochem 48:219-228
5. Hayman AR, Macary P, Lehner PJ, Cox TM (2001) Tartrateresistant acid phosphatase (Acp 5): identification in diverse human tissues and dendritic cells. J Histochem Cytochem 49:675-684
6. Ljusberg J, Ek-Rylander B, Andersson G (1999) Tartrate-resistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases. Biochem J 343 Pt 1:63-69 (Pubitemid 29473878)
7. Ljusberg J, Wang Y, Lang P, Norgard M, Dodds R, Hultenby K, Ek-Rylander B, Andersson G (2005) Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem 280:28370-28381 (Pubitemid 41105735)
8. Oddie GW, Schenk G, Angel NZ, Walsh N, Guddat LW, de Jersey J, Cassady AI, Hamilton SE, Hume DA (2000) Structure, function, and regulation of tartrate-resistant acid phosphatase. Bone 27:575-584
9. Janckila AJ, Takahashi K, Sun SZ, Yam LT (2001) Tartrateresistant acid phosphatase isoform 5b as serum marker for osteoclastic activity. Clin Chem 47:74-80 (Pubitemid 32064278)
10. Rissanen JP, Suominen MI, Peng Z, Halleen JM (2008) Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 82:108-115
11. Halleen JM, Ylipahkala H, Alatalo SL, Janckila AJ, Heikkinen JE, Suominen H, Cheng S, Vaananen HK (2002) Serum tartrateresistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density. Calcif Tissue Int 71:20-25 (Pubitemid 36934772)
12. Halleen JM, Alatalo SL, Suominen H, Cheng S, Janckila AJ, Vaananen HK (2000) Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J Bone Miner Res 15:1337-1345 (Pubitemid 30413866)
13. Halleen JM, Alatalo SL, Janckila AJ, Woitge HW, Seibel MJ, Vaananen HK (2001) Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption. Clin Chem 47:597-600 (Pubitemid 32222482)
14. Adams LM, Warburton MJ, Hayman AR (2007) Human breast cancer cell lines and tissues express tartrate-resistant acid phosphatase (TRAP). Cell Biol Int 31:191-195 (Pubitemid 46187104)
15. Honig A, Rieger L, Kapp M, Krockenberger M, Eck M, Dietl J, Kammerer U (2006) Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study. BMC Cancer 6:199
16. Chao TY, Yu JC, Ku CH, Chen MM, Lee SH, Janckila AJ, Yam LT (2005) Tartrate-resistant acid phosphatase 5b is a useful serum marker for extensive bone metastasis in breast cancer patients. Clin Cancer Res 11:544-550 (Pubitemid 40116878)
17. Jung K, Lein M, Stephan C, Von Hosslin K, Semjonow A, Sinha P, Loening SA, Schnorr D (2004) Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. Int J Cancer 111:783-791 (Pubitemid 39062904)
18. Lyubimova NV, Pashkov MV, Tyulyandin SA, Gol'dberg VE, Kushlinskii NE (2004) Tartrate-resistant acid phosphatase as a marker of bone metastases in patients with breast cancer and prostate cancer. Bull Exp Biol Med 138:77-79 (Pubitemid 39485461)
19. Mose S, Menzel C, Kurth AA, Obert K, Ramm U, Eberlein K, Boettcher HD, Pichlmeier U (2005) Evaluation of tartrate-resistant acid phosphatase (TRACP) 5b as bone resorption marker in irradiated bone metastases. Anticancer Res 25:4639-4645 (Pubitemid 41729525)
20. Chung YC, Ku CH, Chao TY, Yu JC, Chen MM, Lee SH (2006) Tartrate-resistant acid phosphatase 5b activity is a useful bone marker for monitoring bone metastases in breast cancer patients after treatment. Cancer Epidemiol Biomarkers Prev 15:424-428
21. Salminen E, Ala-Houhala M, Korpela J, Varpula M, Tiitinen SL, Halleen JM, Vaananen HK (2005) Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of skeletal changes in prostate cancer. Acta Oncol 44:742-747 (Pubitemid 41547076)
22. Ek-Rylander B, Barkhem T, Ljusberg J, Ohman L, Andersson KK, Andersson G (1997) Comparative studies of rat recombinant purple acid phosphatase and bone tartrate-resistant acid phosphatase. Biochem J 321 (Pt 2): 305):305-311 (Pubitemid 27056473)
23. Lang P, Andersson G (2005) Differential expression of monomeric and proteolytically processed forms of tartrate-resistant acid phosphatase in rat tissues. Cell Mol Life Sci 62:905-918 (Pubitemid 40655637)
24. Wang Y, Norgard M, Andersson G (2005) N-glycosylation influences the latency and catalytic properties of mammalian purple acid phosphatase. Arch Biochem Biophys 435:147-156 (Pubitemid 40170025)
25. Zenger S, Hollberg K, Ljusberg J, Norgard M, Ek-Rylander B, Kiviranta R, Andersson G (2007) Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient mice. Bone 41:820-832 (Pubitemid 47576835)
26. Igarashi Y, Lee MY, Matsuzaki S (2001) Heparin column analysis of serum type 5 tartrate-resistant acid phosphatase isoforms. J Chromatogr B Biomed Sci Appl 757:269-276 (Pubitemid 32441746)
27. Wang Y, Andersson G (2007) Expression and proteolytic processing of mammalian purple acid phosphatase in CHO-K1 cells. Arch Biochem Biophys 461:85-94 (Pubitemid 46627519)
28. Zenger S, Ek-Rylander B, Andersson G (2010) Biogenesis of tartrate-resistant acid phosphatase isoforms 5a and 5b in stably transfected MDA-MB-231 breast cancer epithelial cells. Biochim Biophys Acta 1803:598-607
29. Yam LT, Li CY, Lam KW (1971) Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. N Engl J Med 284:357-360
30. Mose S, Menzel C, Kurth AA, Obert K, Breidert I, Borowsky K, Bottcher HD (2003) Tartrate-resistant acid phosphatase 5b as serum marker of bone metabolism in cancer patients. Anticancer Res 23:2783-2788 (Pubitemid 36969815)
31. Terpos E, de la Fuente J, Szydlo R, Hatjiharissi E, Viniou N, Meletis J, Yataganas X, Goldman JM, Rahemtulla A (2003) Tartrate-resistant acid phosphatase isoform 5b: a novel serum marker for monitoring bone disease in multiple myeloma. Int J Cancer 106:455-457 (Pubitemid 36870411)
32. Janckila AJ, Parthasarathy RN, Parthasarathy LK, Seelan RS, Hsueh YC, Rissanen J, Alatalo SL, Halleen JM, Yam LT (2005) Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells. J Leukoc Biol 77:209-218 (Pubitemid 40315055)
33. Venables JP (2004) Aberrant and alternative splicing in cancer. Cancer Res 64:7647-7654 (Pubitemid 39446889)
34. Ek-Rylander B, Bill P, Norgard M, Nilsson S, Andersson G (1991) Cloning, sequence, and developmental expression of a type 5, tartrate-resistant, acid phosphatase of rat bone. J Biol Chem 266:24684-24689 (Pubitemid 21908996)
35. Baumbach GA, Saunders PT, Ketcham CM, Bazer FW, Roberts RM (1991) Uteroferrin contains complex and high mannose-type oligosaccharides when synthesized in vitro. Mol Cell Biochem 105:107-117
36. Saunders PT, Renegar RH, Raub TJ, Baumbach GA, Atkinson PH, Bazer FW, Roberts RM (1985) The carbohydrate structure of porcine uteroferrin and the role of the high mannose chains in promoting uptake by the reticuloendothelial cells of the fetal liver. J Biol Chem 260:3658-3665 (Pubitemid 15110957)
37. Dube DH, Bertozzi CR (2005) Glycans in cancer and inflammation-potential for therapeutics and diagnostics. Nat Rev Drug Discov 4:477-488 (Pubitemid 40861990)
38. Pollard JW (2009) Trophic macrophages in development and disease. Nat Rev Immunol 9:259-270
39. Smyth MJ, Crowe NY, Godfrey di (2001) NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int Immunol 13:459-463 (Pubitemid 32288543)
40. Hayakawa Y, Takeda K, Yagita H, Smyth MJ, Van Kaer L, Okumura K, Saiki I (2002) IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood 100:1728-1733 (Pubitemid 34925151)
41. Bune AJ, Hayman AR, Evans MJ, Cox TM (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102:103-113 (Pubitemid 32142520)
42. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323
43. Wittrant Y, Theoleyre S, Couillaud S, Dunstan C, Heymann D, Redini F (2003) Regulation of osteoclast protease expression by RANKL. Biochem Biophys Res Commun 310:774-778 (Pubitemid 37188688)
44. Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, Khokha R, Wada T, Penninger JM (2006) Regulation of cancer cell migration and bone metastasis by RANKL. Nature 440:692-696
45. Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS (2008) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol 10:1027-1038
46. Ek-Rylander B, Andersson G (2010) Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrateresistant acid phosphatase. Exp Cell Res 316:443-451
47. Sung V, Gilles C, Murray A, Clarke R, Aaron AD, Azumi N, Thompson EW (1998) The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype. Exp Cell Res 241:273-284 (Pubitemid 28366553)
48. Weber GF, Ashkar S, Cantor H (1997) Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proc Assoc Am Physicians 109:1-9 (Pubitemid 27161044)
49. Christensen B, Kazanecki CC, Petersen TE, Rittling SR, Denhardt DT, Sorensen ES (2007) Cell type-specific posttranslational modifications of mouse osteopontin are associated with different adhesive properties. J Biol Chem 282:19463-19472 (Pubitemid 47100061)
50. Weber GF, Zawaideh S, Hikita S, Kumar VA, Cantor H, Ashkar S (2002) Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol 72:752-761 (Pubitemid 36277847)
51. Sun P, Sleat DE, Lecocq M, Hayman AR, Jadot M, Lobel P (2008) Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins. Proc Natl Acad Sci USA 105:16590-16595
52. Hayman AR, Cox TM (1994) Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein secreted by baculovirus-infected insect cells. J Biol Chem 269:1294-1300
53. Nishikawa M (2008) Reactive oxygen species in tumor metastasis. Cancer Lett 266:53-59