Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes

Journal of Nutritional Biochemistry

Volumn 22, Issue 3, 2011, Pages 276-281

  Kong, Chang Suk ^a   Kim, Jung Ae ^b   Bak, Soon Sun ^b   Byun, Hee Guk ^c   Kim, Se Kwon ^b  

^a Silla University   (South Korea)

^b Pukyong National University   (South Korea)

^c Gangneung Wonju National University   (South Korea)

Author keywords

Adipocyte differentiation; Adipogenesis; AMPK; Aquaporin 7; Lipid accumulation

Indexed keywords

ADENYLATE KINASE; AQUAPORIN 7; CARBOXYMETHYL CHITIN; CHITIN; GLYCEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DOWN REGULATION; GENE EXPRESSION; LIPID STORAGE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-OBESITY AGENTS; AQUAPORINS; CELL DIFFERENTIATION; CHITIN; DOWN-REGULATION; LIPID METABOLISM; MICE; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 79951673532     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.02.005     Document Type: Article

References (30)

1. Xavier F., Sunyer P.I. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002, 10:97-104.
2. Lee W.J., Koh E.H., Won J.C., Kim M.S., Park J.Y., Lee K.U. Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation. Int J Biochem Cell Biol 2005, 37:2254-2259.
3. Giri S., Rattan R., Haq E., Khan M., Yasmin R., Won J.S., et al. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab 2006, 3:31-50.
4. Kim O.K. Ginseng saponin-Re and Coix lachrymajobi var. mayuen regulate obesity related genes expressions, TNF-alpha, leptin, lipoprotein lipase and resistin in 3T3-L1 adipocytes. Korean J Life Sci 2007, 17:1523-1532.
5. Cho E.J., Rahman A., Kim S.W., Baek Y.M., Hwang H.J., Oh J.Y., et al. Chitosan oligosaccharides inhibit adipogenesis in 3T3-L1 adipocytes. J Microbiol Biotechnol 2008, 18:80-87.
6. Tang Q.Q., Otto T.C., Lane M.D. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci U S A 2003, 100:44-49.
7. Hardie D.G., Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 2001, 23:1112-1119.
8. Hwang J.T., Kim S.H., Lee M.S., Kim S.H., Yang H.J., Kim M.J., et al. Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun 2007, 364:1002-1008.
9. Unger R.H. The hyperleptinemia of obesity-regulator of caloric surpluses. Cell 2004, 117:145-146.
10. Rodríguez A., Catalán V., Gómez-Ambrosi J., Frühbeck G. Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice. FEBS Lett 2006, 580:4771-4776.
11. Je J.Y., Kim S.K. Water-soluble chitosan derivatives as a BACE1 inhibitor. Bioorgan Med Chem 2005, 13:6551-6555.
12. Jung W.K., Moon S.H., Kim S.K. Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats. Life Sci 2006, 78:970-976.
13. Laurencin C.T., Jiang T., Kumbar S.G., Nair L.S. Biologically active chitosan systems for tissue engineering and regenerative medicine. Curr Top Med Chem 2008, 8:354-364.
14. Senel S., McClure S. Potential application of chitosan in veterinary medicine. Adv Drug Deliv Rev 2004, 56:1467-1480.
15. Kanatt S.R., Chander R., Sharma A. Chitosan glucose complex-A novel food preservative. Food Chem 2008, 106:521-528.
16. Tokura S., Nishi N., Tsutsumi A., Somorin O. Studies on chitin. VIII. Some properties of water soluble chitn derivatives. Polymer J 1983, 15:485-489.
17. Maeda N., Funahashi T., Shimomura I. Metabolic impact of aquaporin 7 and aquaporin 9. Nat Clin Pract Endocrinol Metab 2008, 4:627-634.
18. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiol Rev 1998, 78:783-809.
19. Salas A., Noé V., Ciudad C.J., Romero M.M., Remesar X., Esteve M. Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue. BMC Genom 2007, 8:292-299.
20. Latasa M.J., Moon Y.S., Kim K.H., Sul H.S. Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element. Proc Natl Acad Sci U S A 2000, 97:10619-10624.
21. Yamaguchi M., Katoh S., Morimoto C., Sakayama K., Shiosaka T., Masuno H., et al. The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats. Int J Obes 2002, 26:610-617.
22. Zhang W., Della-Fera M.A., Hartzell D.L., Hausman D., Baile C.A. Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life Sci 2008, 83:35-42.
23. Ardevol A., Blade C., Salvado M.J., Arola L. Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes. Int J Obes 2000, 24:319-324.
24. Fryer L.G., Carling D. AMP-activated protein kinase and the metabolic syndrome. Biochem Soc Trans 2005, 33:362-366.
25. Luo Z., Saha A.K., Xiang X., Ruderman N.B. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 2005, 26:69-76.
26. Song X.M., Fiedler M., Galuska D., Ryder J.W., Fernstrom M., Chibalin A.V., et al. 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia 2002, 45:56-65.
27. Meisse D., Van de Casteele M., Beauloye C., Hainault I., Kefas B.A., Rider M.H., et al. Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett 2002, 526:38-42.
28. MacDougald O.A., Burant C.F. Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter. Proc Natl Acad Sci U S A 2005, 102:10759-10760.
29. Fruhbeck M., Catalan V., Gómez-Ambrosi J., Rodríguez A. Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. Trends Pharmacol Sci 2006, 27:345-347.
30. Auge F., Hornebeck W., Decarme M., Laronze J.Y. Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives. Bioorg Med Chem Lett 2003, 13:1783-1786.