Enteral feeding in utero induces marked intestinal structural and functional proteome changes in pig fetuses

Pediatric Research

Volumn 69, Issue 2, 2011, Pages 123-128

  Jiang, Pingping ^a   Wan, Jennifer Man Fan ^a   Sit, Wai Hung ^a   Lee, Cheuk Lun ^a   Schmidt, Mette ^b   Sangild, Per T ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; FERRITIN; HEAT SHOCK PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; ARTIFICIAL MILK; CITRIC ACID CYCLE; CONTROLLED STUDY; ENTERIC FEEDING; FETUS; INTESTINE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; SWINE; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; BLOTTING, WESTERN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENTERAL NUTRITION; FEMALE; FETAL PROTEINS; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INTESTINE, SMALL; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PREGNANCY; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE; TIME FACTORS;

EID: 79951641821     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3182042874     Document Type: Article

References (29)

1. Bjornvad CR, Schmidt M, Peterson YM, Jensen SK, Offenberg H, Elnif J, Sangild PT 2005 Preterm birth makes the immature intestine sensitive to feeding-induced intestinal atrophy. Am J Physiol Regul Integr Comp Physiol 289: R1212-R1222 (Pubitemid 41397071)
2. Jiang P, Sangild PT, Sit WH, Ngai HH, Xu R, Siggers JL, Wan JM 2009 Temporal proteomic analysis of intestine developing necrotizing enterocolitis following enteral formula feeding to preterm pigs. J Proteome Res 8:72-81
3. Jiang P, Siggers JL, Ngai HH, Sit WH, Sangild PT, Wan JM 2008 The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding. J Nutr 138:1895-1901
4. Siggers RH, Thymann T, Jensen BB, Molbak L, Heegaard PM, Schmidt M, Buddington RK, Sangild PT 2008 Elective cesarean delivery affects gut maturation and delays microbial colonization but does not increase necrotizing enterocolitis in preterm pigs. Am J Physiol Regul Integr Comp Physiol 294: R929-R938 (Pubitemid 351346972)
5. Che L, Thymann T, Bering SB, LE Huërou-Luron I, D'inca R, Zhang K, Sangild PT 2010 IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs. Pediatr Res 67:54-59
6. Sangild PT, Siggers RH, Schmidt M, Elnif J, Bjornvad CR, Thymann T, Grondahl ML, Hansen AK, Jensen SK, Boye M, Moelbak L, Buddington RK, Westrom BR, Holst JJ, Burrin DG 2006 Diet-and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Gastroenterology 130:1776-1792 (Pubitemid 43668865)
7. Cilieborg MS, Boye M, Thymann T, Jensen BB, Sangild PT Diet-dependent effects of minimal enteral nutrition on intestinal function and necrotizing enterocolitis in preterm pigs. JPEN J Parenter Enteral Nutr, in press
8. Bjornvad CR, Thymann T, Deutz NE, Burrin DG, Jensen SK, Jensen BB, Molbak L, Boye M, Larsson L-I, Schmidt M, Michaelsen KF, Sangild PT 2008 Enteral feeding induces diet-dependent mucosal dysfunction, bacterial proliferation, and necrotizing enterocolitis in preterm pigs on parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 295: G1092-G1103
9. Sangild PT, Trahair JF, Loftager MK, Fowden AL 1999 Intestinal macromolecule absorption in the fetal pig after infusion of colostrum in utero. Pediatr Res 45:595-602 (Pubitemid 29162742)
10. Petersen YM, Burrin DG, Sangild PT 2001 Glp-2 has differential effects on small intestine growth and function in fetal and neonatal pigs. Am J Physiol Regul Integr Comp Physiol 281: R1986-R1993
11. Sangild PT, Mei J, Fowden AL, Xu RJ 2009 The prenatal porcine intestine has low transforming growth factor-beta ligand and receptor density and shows reduced trophic response to enteral diets. Am J Physiol Regul Integr Comp Physiol 296: R1053-R1062
12. Jiang P, Sangild PT, Siggers RH, Sit WH, Lee CL, Wan JM Bacterial colonization affects the intestinal proteome of preterm pigs susceptible to necrotizing enterocolitis. Neonatology, in press
13. Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R 2009 Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats. Am J Physiol Renal Physiol 296: F912-F921
14. Ranganathan S, Walsh E, Godwin A, Tew K 1993 Cloning and characterization of human colon glyoxalase-I. J Biol Chem 268:5661-5667 (Pubitemid 23090890)
15. Wright EM, Martin MG, Turk E 2003 Intestinal absorption in health and disease-sugars. Best Pract Res Clin Gastroenterol 17:943-956
16. Pearce DJ, Taussig D, Simpson C, Allen K, Rohatiner AZ, Lister TA, Bonnet D 2005 Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells 23:752-760 (Pubitemid 40791790)
17. Satoh A, Nakajima Y, Miyahara I, Hirotsu K, Tanaka T, Nishina Y, Shiga K, Tamaoki H, Setoyama C, Miura R 2003 Structure of the transition state analog of medium-chain acyl-coa dehydrogenase. Crystallographic and molecular orbital studies on the charge-transfer complex of medium-chain acyl-coa dehydrogenase with 3-thiaoctanoyl-coa. J Biochem 134:297-304 (Pubitemid 37129109)
18. Urata Y, Koike K, Goto S, Koike M 1991 Novel separation and amino acid sequences of alpha and beta subunits of pig heart pyruvate dehydrogenase. J Nutr Sci Vitaminol (Tokyo) 37:257-267
19. Oste M, Van Haver E, Thymann T, Sangild P, Weyns A, Van Ginneken CJ 2010 Formula induces intestinal apoptosis in preterm pigs within a few hours of feeding. JPEN J Parenter Enteral Nutr 34:271-279
20. Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B 2000 Dietary regulation and localization of apoptosis cascade proteins in the colonic crypt. J Cell Biochem 77:18-29 (Pubitemid 30126891)
21. Petersen AM, Blom J, Andersen LP, Krogfelt KA 2000 Role of strain type, AGS cells and fetal calf serum in helicobacter pylori adhesion and invasion assays. FEMS Immunol Med Microbiol 29:59-67
22. Mallick IH, Yang W, Winslet MC, Seifalian AM 2004 Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49:1359-1377 (Pubitemid 39273608)
23. Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL 2007 Rack1 competes with HSP90 for binding to hif-1α and is required for o2-independent and HSP90 inhibitor-induced degradation of hif-1α. Mol Cell 25:207-217 (Pubitemid 46109612)
24. van Haver ER, Oste M, Thymann T, Sys SU, Lamers WH, Weyns AL, Sangild PT, van Ginneken CJ 2008 Enteral feeding reduces endothelial nitric oxide synthase in the caudal intestinal microvasculature of preterm piglets. Pediatr Res 63:137-142
25. Lu SC 2009 Regulation of glutathione synthesis. Mol Aspects Med 30:42-59
26. Dekaney CM, Wu G, Jaeger la 2003 Gene expression and activity of enzymes in the arginine biosynthetic pathway in porcine fetal small intestine. Pediatr Res 53:274-280 (Pubitemid 36177124)
27. Bailly-Botuha C, Colomb V, Thioulouse E, Berthe M-C, Garcette K, Dubern B, Goulet O, Couderc R, Girardet J-P 2009 Plasma citrulline concentration reflects enterocyte mass in children with short bowel syndrome. Pediatr Res 65:559-563
28. Oste M, Van Ginneken CJ, Van Haver ER, Bjornvad CR, Thymann T, Sangild PT 2005 The intestinal trophic response to enteral food is reduced in parenterally fed preterm pigs and is associated with more nitrergic neurons. J Nutr 135:2657-2663 (Pubitemid 43156610)
29. Wu G, Jaeger LA, Bazer FW, Rhoads JM 2004 Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications. J Nutr Biochem 15:442-451 (Pubitemid 39118490)