Effect of change in transporter expression on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging during hepatocarcinogenesis in rats

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue 3, 2011, Pages 568-576

  Tsuda, Natsuko ^a   Harada, Kenichi ^b   Matsui, Osamu ^b  

^a BAYER YAKUHIN LTD   (Japan)

^b KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Contrast agent; Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid; Magnetic resonance imaging; Rats; Transporter

Indexed keywords

GADOXETIC ACID; MULTIDRUG RESISTANCE PROTEIN 2; NITROSOMORPHOLINE; ORGANIC ANION TRANSPORTER 1; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; HISTOPATHOLOGY; HYPERPLASTIC NODULE; LIVER CARCINOGENESIS; LIVER CIRRHOSIS; LIVER NODULE; LIVER PARENCHYMA; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH;

EID: 79951631266     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06494.x     Document Type: Article

References (25)

1. Libra A, Fernetti C, Lorusso V etal. Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J. Pharmacol. Exp. Ther. 2006; 319: 809-17.
2. Pastor CM, Planchamp C, Pochon S etal. Kinetic of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation. Radiology. 2003; 229: 119-25.
3. Kato N, Yokawa T, Tamura A, Heshiki A, Ebert W, Weinmann HJ. Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid interaction with clinical drugs in rats. Invest. Radiol. 2002; 37: 680-4.
4. Lewin M, Clement O, Belguise-Valladier P etal. Hepatocyte targeting with Gd-EOB-DTPA: potential application for gene therapy. Invest. Radiol. 2001; 36: 9-14.
5. Pascolo L, Petrovic S, Cupelli F etal. ABC protein transport of MRI contrast agents in canalicular rat liver plasma vesicles and yeast vacuoles. Biochem. Biophys. Res. Commun. 2001; 282: 60-6.
6. van Montfoort JE, Stieger B, Meijer DKF, Weinmann HJ, Meier PJ, Fattinger KE. Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide oatp1. J. Pharmacol. Exp. Ther. 1999; 290: 153-7.
7. Pascolo L, Cupelli F, Anelli PL etal. Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents. Biochem. Biophys. Res. Commun. 1999; 257: 746-52.
8. Muhler A, Oude Elferink RP, Weinmann HJ. Complete elimination of the hepatobiliary MR contrast agent Gd-EOB-DTPA in hepatic dysfunction: an experimental study using transport-deficient, mutant rats. MAGMA 1993; 1: 134-9.
9. Tsuda N, Matsui O. Gd-EOB-DTPA-enhanced MRI in rat cirrhotic liver; with reference to transporter activity and morphological changes of bile canaliculi. Radiology 2010; 256: 767-73
10. Hammerstingl R, Huppertz A, Breuer J etal. Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. Eur. Radiol. 2008; 18: 457-67.
11. Huppertz A, Haraida S, Kraus A etal. Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT-Initial observations. Radiology. 2005; 234: 468-78.
12. Tsuda N, Kato N, Murayama C, Narazaki M, Yokawa T. Potential for differential diagnosis with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in experimental hepatic tumors. Invest. Radiol. 2004; 39: 80-8.
13. Groos J, Bannasch P, Schwarz M, Kopp-Schneider A. Comparison of mode of action of four hepatocarcinogens: a model-based approach. Toxicol. Sci. 2007; 99: 446-54.
14. Yoshino H, Futakuchi M, Cho YM etal. Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. Clin. Exp. Metastasis. 2005; 22: 441-7.
15. Dombrowski F, Jost CM, Manekeller S, Evert M. Cocarcinogenic effects of islet hormones and N-nitrosomorpholine in hepatocarcinogenesis after intrahepatic transplantation of pancreatic islets in streptozotocin-diabetic rats. Cancer Res. 2005; 65: 7013-22.
16. Stasiak A, Fogel WA. High voluntary alcohol consumption, in experimental liver cirrhosis is hardly responsive to opioid antagonist treatment. J. Physiol. Pharmacol. 2008; 59: 101-14.
17. Constantinou MA, Theocharis SE, Mikros E. Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats. Toxicol. Appl. Pharmacol. 2007; 218: 11-9.
18. Kang JS, Wanibuchi H, Morimura K etal. Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats. Toxicol. Sci. 2005; 85: 720-6.
19. Yeh CN, MAitra A, Lee KF, Jam YY, Chen MF. Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma. Carcinogenesis. 2004; 25: 631-6.
20. International working party. Terminology of nodular hepatocellular lesions. Hepatology. 1995; 22: 983-93.
21. Liver Cancer Study Group of Japan. General Rules for the Clinical and Pathological Study of Primary Liver Cancer, 5th edn. Tokyo: Kanehara, 2008.
22. Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin. Liver. Dis. 2005; 25: 133-42.
23. Giovanoli O, Heim M, Terracciano L, Bongartz G, Ledermann HP. MRI of hepatic adenomatosis: initial observation with Gadoxetic acid contrast agent in three patients. AJR Am J Roentgenol. 2008; 190: W290-293.
24. Kinoshita M, Miyata M. Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. Hepatology. 2002; 36: 433-8.
25. Hayashi M, Matsui O, Ueda K, Kawamori Y, Gabata T, Kadoya M. Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology. 2002; 225: 143-9.