Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy

Journal of Trauma - Injury, Infection and Critical Care

Volumn 70, Issue 2, 2011, Pages 459-465

  Foresta, Carlo ^a   Schipilliti, Mirko ^a   De Toni, Luca ^a   Magagna, Sabina ^a   Lancerotto, Luca ^a   Azzena, Bruno ^a   Vindigni, Vincenzo ^a   Mazzoleni, Francesco ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Apoptosis.; Endothelial progenitor cells; Escharectomy; Skin burns

Indexed keywords

C REACTIVE PROTEIN; CD133 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; HEMOGLOBIN; VASCULOTROPIN RECEPTOR 2;

ADULT; APOPTOSIS; ARTICLE; BLOOD LEVEL; BODY TEMPERATURE; BURN; CELL HOMING; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ESCHARECTOMY; EXCISION; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HEMATOCRIT; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMAL INJURY;

ADULT; APOPTOSIS; BURNS; CELL COUNT; CHEMOKINE CXCL12; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; RECEPTORS, CXCR4; SKIN; STEM CELLS; TIME FACTORS;

EID: 79951614149     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181fcf83c     Document Type: Article

References (30)

1. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219-1222. (Pubitemid 46718408)
2. Guo Z-R, Sheng CY, Diao L, et al. Extensive wound excision in the acute shock stage in patients with major burns. Burns. 1995;21:139-142.
3. Zan T, Li Q, Dong J, et al. Transplanted endothelial progenitor cells increase neo-vascularisation of rat pre-fabricated flaps. J Plast Reconstr Aesthet Surg. 2010;63:474-481.
4. Asahara T, Masuda H, Takahashi T, et al. Bone marrow oigin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85: 221-228. (Pubitemid 29377293)
5. Shi Q, Rafii S, Wu MH, et al. Evidence for circulating bone marrowderived endothelial cells. Blood. 1998;92:362-367. (Pubitemid 28323695)
6. Krenning G, van Luyn MJ, Harmsen MC. Endothelial progenitor cellbased neovascularization: implications for therapy. Trends Mol Med. 2009;15:180-189.
7. Liew A, Barry F, O'Brien T. Endothelial progenitor cells: diagnostic and therapeutic considerations. Bioessays. 2006;28:261-270.
8. Capla JM, Ceradini DJ, Tepper OM, et al. Skin graft vascularization involves precisely regulated regression and replacement of endothelial cells through both angiogenesis and vasculogenesis. Plast Reconstr Surg. 2006;117:836-844. (Pubitemid 44324518)
9. Suh W, Kim KL, Kim JM, et al. Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes/macrophages and neovascularization. Stem Cells. 2005; 23:1571-1578. (Pubitemid 41741006)
10. Fathke C, Wilson L, Hutter J, et al. Contribution of bone marrowderived cells to skin: Collagen deposition and wound repair. Stem Cells. 2004;22:812-822. (Pubitemid 39166938)
11. Burd A, Ahmed K, Lam S, Ayyappan T, Huang L. Stem cell strategies in burns care. Burns. 2007;33:282-291. (Pubitemid 46428493)
12. Krause DS, Theise ND, Collector MI, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105: 369-377. (Pubitemid 32455343)
13. Furuhata S, Ando K, Oki M, et al. Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol Cell Biochem. 2007;298:125-138. (Pubitemid 46605290)
14. Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 2007;117: 1249-1259. (Pubitemid 46718413)
15. Egan CG, Lavery R, Caporali F, et al. Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes. Diabetologia. 2008;51:1296-1305.
16. Schwartzenberg S, Deutsch V, Maysel-Auslender S, Kissil S, Keren G, George J. Circulating apoptotic progenitor cells: A novel biomarker in patients with acute coronary syndromes. Arterioscler Thromb Vasc Biol. 2007;27:e27-e31. (Pubitemid 46641960)
17. Scheubel RJ, Silber RE, Kuss O, et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol. 2003;42:2073-2080. (Pubitemid 37549887)
18. + cell counts and apoptotic rate in children with acquired aplastic anemia and myelodysplasia. Exp Hematol. 2005;33: 597-604. (Pubitemid 40592177)
19. Fox A, Smythe J, Fisher N, et al. Mobilization of endothelial progenitor cells into the circulation in burned patients. Br J Surg. 2008;95:244-251.
20. Piatkowski A, Gröger A, Pantel M, et al. The extent of thermal injury affects fractions of mononuclearcells. Burns. 2009;35:256-263.
21. Tepper OM, Capla JM, Galiano RD, Bozkurt A, Fuchs PC, Pallua N. Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood. 2005; 105:1068-1077. (Pubitemid 40170877)
22. Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease. 6th ed. Philadelphia: W.B. Saunders Company; 1999.
23. Smythe J, Fox A, Fisher N, Frith E, Harris AL, Watt SM. Measuring angiogenic cytokines, circulating endothelial cells, and endothelial progenitor cells in peripheral blood and cord blood: VEGF and CXCL12 correlate with the number of circulating endothelial progenitor cells in peripheral blood. Tissue Eng Part C Methods. 2008;14:59-67. (Pubitemid 351520452)
24. Gerhardt H. VEGF and endothelial guidance in angiogenic sprouting. Organogenesis. 2008;4:241-246.
25. Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation. 2003;107:1322-1328. (Pubitemid 36314418)
26. + progenitors to peripheral blood. J Exp Med. 1997;185: 111-120. (Pubitemid 27039446)
27. Avniel S, Arik Z, Maly A, et al. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. J Invest Dermatol. 2006;126:468-476. (Pubitemid 43323185)
28. Infanger M, Schmidt O, Kossmehl P, et al. Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema. Burns. 2004;30:305-311. (Pubitemid 38622441)
29. Tonello C, Vindigni V, Zavan B, et al. In vitro reconstruction of an endothelialized skin substitute provided with a microcapillary network using biopolymer scaffolds. FASEB J. 2005;19:1546-1548. (Pubitemid 41279026)
30. Zavan B, Vindigni V, Vezzù K, et al. Hyaluronan based porous nanoparticles enriched with growth factors for the treatment of ulcers: A placebo-controlled study. J Mater Sci Mater Med. 2009;20:235-247.