Metabolism and toxicokinetics of the mycotoxin ochratoxin a in F344 rats

Mycotoxin Research

Volumn 19, Issue 2, 2003, Pages 102-107

  Zepnik, H ^a   Volkel W ^a   Dekant, W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Ochratoxin A; Rats; Tandem mass spectrometry; Toxicokinetics

Indexed keywords

EID: 79951612679     PISSN: 01787888     EISSN: 18671632     Source Type: Journal    
DOI: 10.1007/BF02942946     Document Type: Conference Paper

References (17)

1. Boorman G. A. (1989) TR-358, Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies). NTP Technical Report 358
2. Bundesministerium for Verbraucherschutz, Em/thrung und Landwirtschaft (1999) Belastung des Verbrauchers und der Lebensmittel mit Ochratoxin A. AbschluBbericht und Anhang
3. Dai J. et al. (2002) Detection and characterization of a glutathione conjugate of ochratoxin A. Chem Res Toxicol 15(12): 1581-8
4. Fuchs R. and K. Hult (1992) Ochratoxin A in blood and its pharmacokinetic properties. Food Chem Toxicol 30(3): 201-4
5. Galtier P. et al. (1981) The pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens. Food Cosmet Toxicol 19(6): 735-8
6. Gautier J. et al. (2001) Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Chem Res Toxicol 14(1): 34-45
7. Gross-Steinmeyer K. et al. (2002) Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes. J Agric Food Chem 50(4): 938-45
8. Hagelberg S. et al. (1989) Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J Appl Toxicol 9(2): 91-6
9. Kamimura H. et al. (1988) Metabolic fate of indeloxazine hydrochloride: alphaglucoside formation in rats. Xenobiotica 18(2): 141-9
10. Li S. et al. (1997) Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol Appl Pharmacol 145(I): 82-90
11. Li S. et al. (1998) Confirmation of Ochratoxins in Biological Samples by Conversion into Methyl Esters in Acidified Methanol. J. Agric. Food Chem. 46(10): 4307-4312
12. Li S. et al. (2000) Identification of ochratoxins and some of their metabolites in bile and urine of rats. Food Chem Toxicol 38(2-3): 141-52
13. Pfohl-Leszkowicz A. et al. (1993) Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects. IARC Sci Publ(124): 141-8
14. Storen O. et al. (1982) Metabolism of ochratoxin A by rats. Appl Environ Microbiol 44(4): 785-9
15. Suzuki S. et al. (1977) The pharmacokinetics of ochratoxin A in rats. Jpn J Pharmacol 27(5): 735-44
16. Tatu C. A. et al. (1998) The etiology of Balkan endemic nephropathy: still more questions than answers. Environ Health Perspect 106(11): 689-700
17. Zepnik H. et al. (2001) Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites? Toxicol Sci 59(1): 59-67