Effect of hydrolysed egg protein on brain tryptophan availability

British Journal of Nutrition

Volumn 105, Issue 4, 2011, Pages 611-617

  Mitchell, E Siobhan ^a   Slettenaar, Marieke ^a   Quadt, Frits ^a   Giesbrecht, Timo ^a   Kloek, Joris ^b   Gerhardt, Cindy ^b   Bot, Arjen ^a   Eilander, Ans ^a   Wiseman, Sheila ^a  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b DSM FOOD SPECIALTIES   (Netherlands)

Author keywords

Bioavailability; Egg protein; l Type transporter; Large neutral amino acids; Milk protein; Pharmacokinetics; Serotonin

Indexed keywords

EGG PROTEIN; ISOLEUCINE; LEUCINE; MILK PROTEIN; PHENYLALANINE; PROTEIN HYDROLYSATE; TRYPTOPHAN; TYROSINE; VALINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID BRAIN LEVEL; ARTICLE; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEALTH FOOD; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN;

ADULT; AMINO ACIDS, NEUTRAL; ANIMALS; BRAIN; CROSS-OVER STUDIES; DIET; DIETARY PROTEINS; DOUBLE-BLIND METHOD; EGGS; FEMALE; HUMANS; HYDROLYSIS; MALE; MIDDLE AGED; MILK; SEROTONIN; TRYPTOPHAN;

EID: 79951610703     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510004150     Document Type: Article

References (16)

1. Silber BY & Schmitt JA (2010) Effects of tryptophan loading on human cognition, mood, and sleep. Neurosci Biobehav Rev 34, 387-407.
2. Markus CR, Firk C, Gerhardt C, et al. (2008) Effect of different tryptophan sources on amino acids availability to the brain and mood in healthy volunteers. Psychopharmacology 201, 107-114.
3. Markus CR (2005) Evening intake of alpha-lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. Am J Clin Nutr 81, 1026-1033. (Pubitemid 41724943)
4. Markus CR, Panhuysen G, Tuiten A, et al. (1998) Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task? Appetite 31, 49-65. (Pubitemid 28421057)
5. Firk C & Markus CR (2009) Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin Nutr 28, 266-271.
6. Fernstrom JD (1994) Dietary amino-acids and brain-function. J Am Diet Assoc 94, 71-77.
7. Beulens JWJ, Bindels JG, de Graaf C, et al. (2004) Alpha-lac-talbumin combined with a regular diet increases plasma Trp-LNAA ratio. Physiol Behav 81, 585-593. (Pubitemid 38716165)
8. Scrutton H, Carbonnier A, Cowen PJ, et al. (2007) Effects of alpha-lactalbumin on emotional processing in healthy women. J Psychopharmacol 21, 519-524. (Pubitemid 47106926)
9. Booij L, Merens W, Markus CR, et al. (2006) Diet rich in alpha-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls. J Psychophar-macol 20, 526-535. (Pubitemid 43875182)
10. Murphy SE, Longhitano C, Ayres RE, et al. (2009) The role of serotonin in nonnormative risky choice: the effects of trypto-phan supplements on the "reflection effect" in healthy adult volunteers. J Cogn Neurosci 21, 1709-1719.
11. Merens W, Booij L, Markus R, et al. (2005) The effects of a diet enriched with alpha-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls. Br J Nutr 94, 415-422. (Pubitemid 41404284)
12. Choi SJ, DiSilvio B, Fernstrom MH, et al. (2009) Meal inges-tion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates. Phys Behav 98, 156-162.
13. Delgado-Andrade C, Rufian-Henares JA, Jimenez-Perez S, et al. (2006) Tryptophan determination in milk-based ingredients and dried sport supplements by liquid chroma-tography with fluorescence detection. Food Chem 98, 580-585.
14. Markus CR (2002) Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr 75, 1051-1056. (Pubitemid 34547535)
15. Scrutton H, Carbonnier A, Cowen PJ, et al. (2007) Effects of alpha-lactalbumin on emotional processing in healthy women. J Psychopharmacol 21, 519-524. (Pubitemid 47106926)
16. Caballero B, Finer N & Wurtman RJ (1988) Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements. Metabolism 37, 672-676.