An open-label study assessing the safety and efficacy of alitretinoin in patients with severe chronic hand eczema unresponsive to topical corticosteroids

Clinical and Experimental Dermatology

Volumn 36, Issue 2, 2011, Pages 149-154

  Dirschka, T ^a   Reich, K ^b   Bissonnette, R ^c   Maares, J ^d   Brown, T ^d   Diepgen, T L ^e  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b Dermatologikum Hamburg   (Germany)

^c INNOVADERM RESEARCH   (Canada)

^d BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CORTICOSTEROID; EMOLLIENT AGENT; IBUPROFEN; PARACETAMOL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANGIONEUROTIC EDEMA; ARTICLE; CHEILITIS; CHOLESTEROL BLOOD LEVEL; CHRONIC DISEASE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CREATINE KINASE BLOOD LEVEL; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DRY EYE; DRY SKIN; ERYTHEMA; FATIGUE; FEMALE; FLUSHING; HAND ECZEMA; HEADACHE; HUMAN; INFLUENZA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MIGRAINE; NAUSEA AND VOMITING; PAIN; PRIORITY JOURNAL; PRURITUS; RHINOPHARYNGITIS; RISK ASSESSMENT; SIDE EFFECT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; VISUAL ANALOG SCALE; XEROSTOMIA;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; CHRONIC DISEASE; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUCOCORTICOIDS; HAND DERMATOSES; HUMANS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TREATMENT FAILURE; TREATMENT OUTCOME; TRETINOIN; YOUNG ADULT;

EID: 79951592046     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2010.03955.x     Document Type: Article

References (9)

1. Diepgen TL, Elsner P, Schliemann S et al. Guideline on the management of hand eczema ICD-10 Code: L20, L23, L24, L25, L30. J Dtsch Dermatol Ges 2009; 7 (Suppl. 3): S1-16.
2. Diepgen TL, Agner T, Aberer W et al. Management of chronic hand eczema. Contact Derm 2007; 57: 203-10.
3. Orfanos CE, Zouboulis CC. Oral retinoids in the treatment of seborrhoea and acne. Dermatology 1998; 196: 140-7.
4. Ruzicka T, Lynde CW, Jemec GB et al. Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 2008; 158: 808-17.
5. Coenraads PJ, Van Der Walle H, Thestrup-Pedersen K et al. Construction and validation of a photographic guide for assessing severity of chronic hand dermatitis. Br J Dermatol 2005; 152: 296-301.
6. Ruzicka T, Larsen FG, Galewicz D et al. Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 2004; 140: 1453-9.
7. Blome C, Maares J, Diepgen T et al. Measurement of patient-relevant benefits in the treatment of chronic hand eczema - a novel approach. Contact Derm 2009; 61: 39-45.
8. Landow K. Hand dermatitis. The perennial scourge. Postgrad Med 1998; 8: 151-2.
9. Rook A, Wilkinson DS, Ebling FJG et al., eds. Rook/Wilkinson/Ebling Textbook of Dermatology, 6th edn. Oxford: Blackwell Science, 1998.