Characterization of inositol phospho-sphingolipid-phospholipase C 1 (Isc1) in Cryptococcus neoformans reveals unique biochemical features

FEBS Letters

Volumn 585, Issue 4, 2011, Pages 635-640

  Henry, Jennifer ^a   Guillotte, Aimee ^a   Luberto, Chiara ^a   Del Poeta, Maurizio ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cryptococcus neoformans; Inositol sphingolipids; Phospholipase C; Phytoceramide; Plasma membrane ATPase; Sphingomyelin

Indexed keywords

INOSITOL PHOSPHOSPHINGOLIPID PHOSPHOLIPASE C1; PHOSPHOLIPASE; SPHINGOLIPID; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CELL STRESS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ENZYME ACTIVITY; FUNGAL CELL; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL;

CERAMIDES; CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; GLYCOSPHINGOLIPIDS; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; SPHINGOLIPIDS; STRESS, PHYSIOLOGICAL; SUBSTRATE SPECIFICITY; TYPE C PHOSPHOLIPASES;

FILOBASIDIELLA NEOFORMANS; FUNGI; MAMMALIA;

EID: 79951581102     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.01.015     Document Type: Article

References (34)

1. A. Casadevall, and J.R. Perfect Cryptococcus neoformans 1998 ASM Press Washington, DC pp. 381-405
2. M. Feldmesser, Y. Kress, P. Novikoff, and A. Casadevall Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection Infect. Immun. 68 2000 4225 4237 (Pubitemid 30434578)
3. D.L. Goldman, S.C. Lee, A.J. Mednick, L. Montella, and A. Casadevall Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide Infect. Immun. 68 2000 832 838 (Pubitemid 30056543)
4. M. Feldmesser, S. Tucker, and A. Casadevall Intracellular parasitism of macrophages by Cryptococcus neoformans Trends Microbiol. 9 2001 273 278 (Pubitemid 32522807)
5. S.M. Levitz Cryptococcus neoformans: intracellular or extracellular? Trends Microbiol. 9 2001 417 418
6. J.N. Steenbergen, H.A. Shuman, and A. Casadevall Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages Proc. Natl. Acad. Sci. USA 98 2001 15245 15250 (Pubitemid 34013999)
7. L.J. Heung, C. Luberto, A. Plowden, Y.A. Hannun, and M. Del Poeta The sphingolipid pathway regulates protein kinase C 1 (Pkc1) through the formation of diacylglycerol (DAG) in Cryptococcus neoformans J. Biol. Chem. 279 2004 21144 21153 (Pubitemid 38656517)
8. L.J. Heung, A.E. Kaiser, C. Luberto, and M. Del Poeta The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans J. Biol. Chem. 280 2005 28547 28555 (Pubitemid 41105755)
9. L. Mare, R. Iatta, M.T. Montagna, C. Luberto, and M. Del Poeta APP1 transcription is regulated by IPC1-DAG pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans J. Biol. Chem. 280 2005 36055 36064 (Pubitemid 41633876)
10. N. Tommasino, M. Villani, A. Qureshi, J. Henry, C. Luberto, and M. Del Poeta Atf2 transcription factor binds to the APP1 promoter in Cryptococcus neoformans: stimulatory effect of diacylglycerol Eukaryot. Cell 7 2008 294 301 (Pubitemid 351959696)
11. C. Luberto, D.L. Toffaletti, E.A. Wills, S.C. Tucker, A. Casadevall, J.R. Perfect, Y.A. Hannun, and M. Del Poeta Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans Genes Dev. 15 2001 201 212 (Pubitemid 32107665)
12. J. Shea, T.B. Kechichian, C. Luberto, and M. Del Poeta The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C (Isc1) confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system Infect. Immun. 74 2006 5977 5988 (Pubitemid 44484585)
13. T.B. Kechichian, J. Shea, and M. Del Poeta Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice Infect. Immun. 75 2007 4792 4798 (Pubitemid 47502148)
14. P.C. Rittershaus, T.B. Kechichian, J. Allegood, A.H.J. Merrill, M. Hennig, C. Luberto, and M. Del Poeta Glucosylceramide is an essential regulator of pathogenicity of Cryptococcus neoformans J. Clin. Invest. 116 2006 1651 1659
15. H. Sawai, Y. Okamoto, C. Luberto, C. Mao, A. Bielawska, N. Domae, and Y.A. Hannun Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae J. Biol. Chem. 275 2000 39793 39798 (Pubitemid 32059011)
16. O. Zhang Degradation of host sphingomyelin is essential for Leishmania virulence PLoS Pathog. 5 2009 e1000692
17. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 226 1957 497 509
18. T.A. Jones, J.Y. Zou, S.W. Cowan, and M. Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models Acta Crystallogr A 47 1991 110 119
19. Y. Okamoto, S. Vaena de Avalos, and Y.A. Hannun Structural requirements for selective binding of ISC1 to anionic phospholipids J. Biol. Chem. 277 2002 46470 46477 (Pubitemid 35417643)
20. Y. Okamoto, S. Vaena de Avalos, and Y.A. Hannun Functional analysis of ISC1 by site-directed mutagenesis Biochemistry 42 2003 7855 7862 (Pubitemid 36758951)
21. Y. Matsuo, A. Yamada, K. Tsukamoto, H. Tamura, H. Ikezawa, H. Nakamura, and K. Nishikawa A distant evolutionary relationship between bacterial sphingomyelinase and mammalian DNase I Protein Sci. 5 1996 2459 2467 (Pubitemid 26424858)
22. H. Ago, M. Oda, M. Takahashi, H. Tsuge, S. Ochi, N. Katunuma, M. Miyano, and J. Sakurai Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus J. Biol. Chem. 281 2006 16157 16167 (Pubitemid 43848511)
23. T. Okazaki, R.M. Bell, and Y.A. Hannun Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation J. Biol. Chem. 264 1989 19076 19080 (Pubitemid 19285812)
24. F.G. Tafesse, K. Huitema, M. Hermansson, S. van der Poel, J. van den Dikkenberg, A. Uphoff, P. Somerharju, and J.C. Holthuis Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells J. Biol. Chem. 282 2007 17537 17547 (Pubitemid 47100300)
25. P.A. Trinel, E. Maes, J.P. Zanetta, F. Delplace, B. Coddeville, T. Jouault, G. Strecker, and D. Poulain Candida albicans phospholipomannan, a new member of the fungal mannose inositol phosphoceramide family J. Biol. Chem. 277 2002 37260 37271
26. K. Barr, and R.L. Lester Occurrence of novel antigenic phosphoinositol-containing sphingolipids in the pathogenic yeast Histoplasma capsulatum Biochemistry 23 1984 5581 5588
27. K. Barr, R.A. Laine, and R.L. Lester Carbohydrate structures of three novel phosphoinositol-containing sphingolipids from the yeast Histoplasma capsulatum Biochemistry 23 1984 5589 5596
28. J. Garcia, J. Shea, F. Alvarez-Vasquez, A. Qureshi, C. Luberto, E.O. Voit, and M. Del Poeta Mathematical modeling of pathogenicity of Cryptococcus neoformans Mol. Syst. Biol. 4 2008 183 195
29. B. Gaigg, B. Timischl, L. Corbino, and R. Schneiter Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast J. Biol. Chem. 280 2005 22515 22522 (Pubitemid 40827909)
30. B. Gaigg, A. Toulmay, and R. Schneiter Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast J. Biol. Chem. 281 2006 34135 34145 (Pubitemid 46036622)
31. M.C. Lee, S. Hamamoto, and R. Schekman Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum J. Biol. Chem. 277 2002 22395 22401 (Pubitemid 34967208)
32. D. Garcia-Hermoso, G. Janbon, and F. Dromer Epidemiological evidence for dormant Cryptococcus neoformans infection J. Clin. Microbiol. 37 1999 3204 3209 (Pubitemid 29455206)
33. F. Dromer, O. Ronin, and B. Dupont Isolation of Cryptococcus neoformans var. gattii from an Asian patient in France: evidence for dormant infection in healthy subjects J. Med. Vet. Mycol. 30 1992 395 397
34. J. Daniel, C. Deb, V.S. Dubey, T.D. Sirakova, B. Abomoelak, H.R. Morbidoni, and P.E. Kolattukudy Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture J. Bacteriol. 186 2004 5017 5030 (Pubitemid 38970829)