Neuroendocrine tumors express PAC1 receptors

Annals of the New York Academy of Sciences

Volumn 1070, Issue , 2006, Pages 399-404

  Lieu, Song N ^a   Oh, David S ^a   Pisegna, Joseph R ^a   Germano, Patricia M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BON; Carcinoid tumor; PACAP

Indexed keywords

CHROMOGRANIN A; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; NEUROTENSIN; SEROTONIN;

BINDING AFFINITY; CELL GROWTH; CELL STIMULATION; CONFERENCE PAPER; IMMUNOHISTOCHEMISTRY; MECHANICAL STIMULATION; NEUROENDOCRINE TUMOR; PROTEIN EXPRESSION; RECEPTOR BINDING; SEROTONIN RELEASE;

EID: 33746404164     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1317.052     Document Type: Conference Paper

References (14)

1. PISEGNA, J.R. & M.P. SAWICKI. 2001. Neuroendocrine pancreas. In Cancer Treatment. C.M. HASKELL & J.S. BEREK Eds: 1065-1081. Saunders. Philadelphia, PA.
2. PAREKH, D., J. ISHIZUKA, C.M. TOWNSEND JR., et al. 1994. Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage, and secretion. Pancreas 9: 83-90.
3. ZIA, F., M. FAGARASAN, K. BITAR, et al. 1996. PACAP receptors regulate the growth of non-small cell lung cancer cells. Cancer Res. 55: 4886-4891.
4. LEYTON, J., Y. GOZES, J.R. PISEGNA, et al. 1999. PACAP (6-38) is a PACAP receptor antagonist for breast cancer cells. Breast Cancer Res. Treat. 56: 177-186.
5. LE, S.V., D.J. YAMAGUCHI, C.A. MC ARDLE, et al. 2002. PAC1 and PACAP expression, signaling, and effect in the growth of HCT8, human colonic tumor cells. Regul. Pept. 109: 115-125.
6. PISEGNA, J.R. & S.A. WANK. 1996. Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cylcase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C. J. Biol. Chem. 271: 17267-17274.
7. ISHIHARA, T., R. SHIGEMOTO, K. MORI, et al. 1992. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8: 811-819.
8. LUTZ, E.M., W.J. SHEWARD, K.M. WEST, et al. 1993. The VIP2 receptor: molecular characterization of a cDNA encoding a novel receptor for vasoactive intestinal peptide. FEBS 334: 3-8.
9. PISEGNA, J.R. & S.A. WANK. 1993. Molecular cloning and functional expression of the pituitary adenylate cylcase-activating polypeptide type I receptor. Proc. Natl. Acad. Sci. USA 90: 6345-6349.
10. SPENGLER, D., C. WAEBER, C. PANTALONI, et al. 1993. Differential signal transduction by five splice variants of the PACAP receptor. Nature 365: 170-175.
11. HARMER, A.J., A. ARIMURA, I. GOZES, et al. 1998. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev. 50: 265-270.
12. MIAMPAMBA, M., P.M. GERMANO, S. ARLI, et al. 2002. Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type I receptor in the rat gastric and coloine myenteric neurons. Regul. Pept. 105: 145-154.
13. PISEGNA, J.R., J. LEYTON, T. COELHO, et al. 1997. Differential activation of immediate-early gene expression by four splice variants of the human pituitary activating polypeptide receptor: evident for activation by PACAP hybrid and the phospholipase C inhibitor U73122. Life Sci. 61: 631-639.
14. ZENG, N., C. ATHMANN, T. KANG, et al. 1999. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. J. Clin. Invest. 104: 1383-1391.