Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy

British Journal of Haematology

Volumn 152, Issue 5, 2011, Pages 669-672

  Pichler, Monika M ^a   Bodner, Claudia ^a   Fischer, Carina ^b   Deutsch, Alexander J ^a   Hiden, Karin ^a   Beham Schmid, Christine ^c   Linkesch, Werner ^a   Guelly, Christian ^b   Sill, Heinz ^a   Wölfler, Albert ^a  

^a Division of Haematology   (Austria)

^b Center for Medical Research   (Austria)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Acute myeloid leukaemia; Molecular genetics; Mutation analysis; Myelodysplastic syndromes

Indexed keywords

2 OXOGLUTARIC ACID; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE (NADP); JANUS KINASE 2;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; BONE MARROW BIOPSY; CATALYSIS; CHRONIC MYELOMONOCYTIC LEUKEMIA; COPY NUMBER VARIATION; ENZYME ACTIVITY; GENE MUTATION; HETEROZYGOSITY; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; KARYOTYPE; LETTER; MAJOR CLINICAL STUDY; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH EXCESS BLASTS; SINGLE NUCLEOTIDE POLYMORPHISM; UNIPARENTAL DISOMY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; ISOCITRATE DEHYDROGENASE; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; NEOPLASMS, SECOND PRIMARY; UNIPARENTAL DISOMY; YOUNG ADULT;

EID: 79951555960     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08404.x     Document Type: Letter

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