Biodegradable chitosan-based ambroxol hydrochloride microspheres: Effect of cross-linking agents

Journal of Young Pharmacists

Volumn 3, Issue 1, 2011, Pages 9-14

  Gangurde, H H ^a,c   Chavan, N V ^a   Mundada, A S ^a   Derle, D V ^b   Tamizharasi, S ^c  

^a SNJB's Shriman Suresh Dada Jain College of Pharmacy   (India)

^b NDMVP Samaj's College of Pharmacy   (India)

^c NANDHA COLLEGE OF PHARMACY   (India)

Author keywords

Ambroxol hydrochloride; Chitosan microspheres; Cross linking agents

Indexed keywords

AMBROXOL; CHITOSAN; FORMALDEHYDE; MICROSPHERE;

ARTICLE; BIODEGRADABILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; HEAT TREATMENT; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROENCAPSULATION; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

EID: 79851507003     PISSN: 09751483     EISSN: 09751505     Source Type: Journal    
DOI: 10.4103/0975-1483.76414     Document Type: Article

References (18)

1. Lee HJ, Joung SK, Kim YG, Yoo JY, Han SB. Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers. Pharm Research 2004;49:93-8. (Pubitemid 37324909)
2. Villacampa J, Alchntar F, Rodriguez JM, Morales JM, Herrera J, Rosete R. Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. Clin Ther 2003;25:2225-32. (Pubitemid 37076315)
3. Reynolds JEF: Martindale- The Extra Pharmacopoeia, 31st ed. London: Royal Pharmaceutical Press; 1996. p. 404-1062.
4. British Pharmacopoeia. Cambridge: University Printing House; 2002. p. 211.
5. Kubo W, Miyazaki S, Dairaku M, Togashi M, Mikamib R, Attwood D. Oral sustained delivery of ambroxol from in-situ gelling pectin formulations. Int J Pharm 2004;271:233-40. (Pubitemid 38210101)
6. Itoh K, Hirayama T, Takahashi A, Kubo W, Miyazaki S, Dairaku M, et al. In-situ gelling pectin formulations for oral drug delivery at high gastric pH. Int J Pharm 2006;10:42.
7. Basak SC, Jayakumar RBM, Lucas MKP. Formulation and release behavior of sustained release ambroxol hydrochloride HPMC matrix tablet. Indian J Pharm Sci 2006;68:594-8. (Pubitemid 46087767)
8. Anal AK, Stevens WF, Lopez CR. Ionotropic cross-linked chitosan microspheres for controlled release of ampicillin. Int J Pharm 2006;312: 166-73.
9. Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, et al. Chitosan microspheres as a potential carrier for drugs. Int J Pharm 2004;274:1-33. (Pubitemid 38457003)
10. Espinar FJ, Gonzalez AG, Igea SA, Mendez JB. Chitosan and chondroitin microspheres for oral administration controlled release of metoclopramide. Eur J Pharm Biopharm 1999;48:149-55. (Pubitemid 29401991)
11. Onishi H, Oosegi T, Machida Y, McGinity JW. Preparation and in vitro evaluation of chitosan microspheres containing prednisolone: comparison of simple and conjugate microspheres. Drug Dev Ind Pharm 2005;31:597-605. (Pubitemid 41356201)
12. Giunchedi P, Genta I, Conti B, Muzzarelli RAA, Conte U. Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres. Biomaterials 1998;19:157-61. (Pubitemid 28239479)
13. Gavini E, Hegge AB, Rassu G, Sanna V, Testa C, Pirisino G, et al. In vitro/ in vivo Nasal administration of carbamezepine using chitosan microspheres studies. Int J Pharm 2006;307:9-15. (Pubitemid 41773246)
14. Patil SB, Murthy RSR. Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration. Indian J Pharm Sci 2006;68:64-7.
15. Akbuga J, Bergisadi N. Effect of formulation variables on cis-platin loaded chitosan microsphere properties. J Microencap 1999;16:697-703. (Pubitemid 29478949)
16. Corrigan DO, Healy AM, Corrigan OI. Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates. Eur J Pharm Biopharm 2006;62:295-305. (Pubitemid 43356579)
17. Kumbar SG, Kulkarni AR, Aminabhavi TM. Cross-linked chitosan microspheres for encapsulation of diclofenac sodium: Effect of crosslinking agent. J Microencap 2002;19:173-80. (Pubitemid 34100610)
18. Muzzarelli RA, Rocchetti R. Determination of degree of acetylation of chitosan by first derivative ultraviolet spectrophotometry. Carbohydrate Polymers 1985;5:461-72.