Non-invasive management of non-melanoma skin cancer in patients with cancer predisposition genodermatosis: A role for confocal microscopy and photodynamic therapy

Journal of the European Academy of Dermatology and Venereology

Volumn 25, Issue 7, 2011, Pages 819-827

  Segura, S ^a,b   Puig, S ^a,c   Carrera, C ^a   Lecha, M ^a   Borges, V ^a   Malvehy, J ^a,c  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Gorlin syndrome; Photodynamic therapy; Reflectance confocal microscopy; Xeroderma pigmentosum

Indexed keywords

AMINOLEVULINIC ACID METHYL ESTER;

ADULT; ARTICLE; BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; CANCER PATIENT; CANCER REGRESSION; CANCER SUSCEPTIBILITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONFOCAL MICROSCOPY; DIAGNOSTIC VALUE; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; HYPERPIGMENTATION; MALE; MULTIPLE CYCLE TREATMENT; NON INVASIVE PROCEDURE; OUTCOME ASSESSMENT; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REFLECTANCE CONFOCAL MICROSCOPY; SIBLING; SKIN PAIN; TREATMENT RESPONSE; XERODERMA PIGMENTOSUM;

ADULT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICROSCOPY, CONFOCAL; PHOTOCHEMOTHERAPY; PROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 79851506541     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03871.x     Document Type: Article

References (36)

1. Gorlin RJ, Goltz RW. Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rips. N Engl J Med 1960; 262: 909-912.
2. Gorlin RJ. Nevoid basal cell carcinoma syndrome. Dermatol Clin 1995; 13: 113-125.
3. Manfredi M, Vescovi P, Bonanini M, Porter S. Nevoid basal cell carcinoma syndrome: a review of the literature. Int J Oral Maxillofac Surg 2003; 33: 117-124.
4. Farndon PA, Del Mastro RG, Evans DG, Kilpatrick MW. Location of the gene for Gorlin syndrome. Lancet 1992; 339: 581-582.
5. Unden AB, Holmberg E, Lundh-Rozell B et al. Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation. Cancer Res 1996; 56: 4562-4565. (Pubitemid 26338046)
6. Honavar SG, Shields JA, Shields CL et al. Basal cell carcinoma of the eyelid associated with Gorlin-Goltz syndrome. Ophthalmology 2001; 108: 1115-1123. (Pubitemid 32500030)
7. Kolm I, Puig S, Iranzo P, Malvehy J. Dermoscopy in Gorlin-Goltz syndrome. Dermatol Surg 2006; 32: 847-851. (Pubitemid 43847124)
8. Bootsma D, Hoeijmakers JHJ. The genetic basis of xeroderma pigmentosum. Ann Genet 1991; 34: 143-150.
9. Cleaver JE. Xeroderma pigmentosum: biochemical and genetic characteristics. Ann Rev Genet 1975; 9: 19-38.
10. Robbins JH, Kraemer KH, Lutzner MA et al. Xeroderma pigmentosum: an inherited disease with sun sensitivity, multiple cutaneous neoplasm, and abnormal DNA repair. Ann Intern Med 1974; 80: 221-248.
11. Davis BE, Koh HK, Rohrer TE et al. Sunlight avoidance and cancer prevention in xeroderma pigmentosum. Arch Dermatol 1994; 130: 806-808. (Pubitemid 24182702)
12. Malvehy J, Puig S, Martí-Laborda RM. Dermoscopy of skin lesions in two patients with xeroderma pigmentosum. Br J Dermatol 2005; 152: 271-278. (Pubitemid 40343597)
13. Green WH, Wang SQ, Cognetta AB Jr. Total-body cutaneous examination, total-body photography, and dermoscopy in the care of a patient with xeroderma pigmentosum and multiple melanomas. Arch Dermatol 2009; 145: 910-915.
14. Rajadhyasksha M, González S, Zavislan JM et al. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol 1999; 113: 293-303.
15. González S, Tannus Z. Real-time in vivo confocal reflectance microscopy of basal cell carcinoma. J Am Acad Dermatol 2002; 47: 869-874. (Pubitemid 35403045)
16. Pellacani G, Guitera P, Longo C et al. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 2007; 127: 2759-2765. (Pubitemid 350134828)
17. Scope A, Benvenuto-Andrade C, Agero AL et al. In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol 2007; 57: 644-658.
18. Ulrich M, Maltusch A, Rius-Diaz F et al. Clinical applicability of in vivo reflectance confocal microscopy for the diagnosis of actinic keratoses. Dermatol Surg 2008; 34: 610-619. (Pubitemid 351569479)
19. Segura S, Puig S, Carrera C et al. Development of a two-step method for the diagnosis of melanoma by reflectance confocal microscopy. J Am Acad Dermatol 2009; 61: 216-229.
20. Guitera P, Pellacani G, Longo C et al. In vivo reflectance confocal microscopy enhances secondary evaluation of melanocytic lesions. J Invest Dermatol 2009; 129: 131-138.
21. Morton CA, McKenna KE, Rhodes LE. British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group Guidelines for topical photodynamic therapy: update. Br J Dermatol 2008; 159: 1245-1266.
22. Wolf P, Kerl H. Photodynamic therapy in patient with xeroderma pigmentosum. Lancet 1991; 337: 1613-1614.
23. Oseroff AR, Shieh S, Frawley NP et al. Treatment of diffuse basal cell carcinomas and basaloid follicular hamartomas in nevoid basal cell carcinoma syndrome by wide area 5- aminolevulinic acid photodynamic therapy. Arch Dermatol 2005; 141: 60-67. (Pubitemid 40144441)
24. Mougel F, Debarbieux S, Ronger-Savlé S et al. Methylaminolaevulinate photodynamic therapy in patients with multiple basal cell carcinomas in the setting of Gorlin-Goltz syndrome or after radiotherapy. Dermatology 2009; 219: 138-142.
25. Loncaster J, Swindell R, Slevin F et al. Efficacy of photodynamic therapy as a treatment for Gorlin syndrome-related basal cell carcinomas. Clin Oncol (R Coll Radiol) 2009; 21: 502-508.
26. Stockfleth E, Ulrich C, Hauschild A et al. Successful treatment of basal cell carcinomas in a nevoid basal cell carcinoma syndrome with topical 5% imiquimod. Eur J Dermatol 2002; 12: 569-572. (Pubitemid 35440796)
27. Nagore E, Sevila A, Sanmartín O et al. Excellent response of basal cell carcinomas and pigmentary changes in xeroderma pigmentosum to imiquimod 5% cream. Br J Dermatol 2003; 149: 858-861. (Pubitemid 37412010)
28. Goldgeier M, Fox CA, Zavislan JM et al. Noninvasive imaging, treatment, and microscopic confirmation of clearance of basal cell carcinoma. Dermatol Surg 2003; 29: 205-210. (Pubitemid 36343513)
29. Torres A, Niemeyer A, Berkes B et al. 5% imiquimod cream and reflectance- mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma. Dermatol Surg 2004; 30(12 Pt 1): 1462-1469. (Pubitemid 40053555)
30. Agero AL, Busam KJ, Benvenuto-Andrade C et al. Reflectance confocal microscopy of pigmented basal cell carcinoma. J Am Acad Dermatol 2006; 54: 638-643.
31. Segura S, Puig S, Carrera C et al. Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. Arch Dermatol 2007; 143: 883-886. (Pubitemid 47076486)
32. Stender IM, Bech-Thomsen N, Poulsen T, Wulf HC. Photodynamic therapy with topical delta-aminolevulinic acid delays UV photocarcinogenesis in hairless mice. Photochem Photobiol 1997; 66: 493-496. (Pubitemid 127470195)
33. Sharfaei S, Juzenas P, Moan J, Bissonnette R. Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice. Arch Dermatol Res 2002; 294: 237-242. (Pubitemid 34762299)
34. Caty V, Liu Y, Viau G, Bissonnette R. Multiple large surface photodynamic therapy sessions with topical methyl aminolaevulinate in PTCH heterozygous mice. Br J Dermatol 2006; 154: 740-742. (Pubitemid 43374102)
35. Korbelik M, Dougherty GJ. Photodynamic therapy-mediated immune response against subcutaneous mouse tumours. Cancer Res 1999; 59: 1941-1946. (Pubitemid 29186169)
36. Oseroff A. PDT as a cytotoxic agent and biological response modifier: implications for cancer prevention and treatment in immunosuppressed and immunocompetent patients. J Invest Dermatol 2006; 126: 542-544. (Pubitemid 43255638)