메뉴 건너뛰기




Volumn 27, Issue 1, 2011, Pages 170-180

Supermacroporous polymer-based cryogel bioreactor for monoclonal antibody production in continuous culture using hybridoma cells

Author keywords

Antibody production; Continuous culture; Cryogel bioreactor; Hybridoma cells; Polymer scaffolds

Indexed keywords

ANTIBODY PRODUCTION; CONTINUOUS CULTURE; CRYOGELS; HYBRIDOMA CELLS; POLYMER SCAFFOLDS;

EID: 79851498044     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.497     Document Type: Article
Times cited : (30)

References (50)
  • 1
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nat Biotechnol. 2005; 23: 1147-1157.
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 2
    • 0035313635 scopus 로고    scopus 로고
    • Industrial choices for protein production by large-scale cell culture
    • Chu L, Robinson DK. Industrial choices for protein production by large-scale cell culture. Curr Opin Biotechnol. 2001; 12: 180-187.
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 180-187
    • Chu, L.1    Robinson, D.K.2
  • 4
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975; 256: 495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 5
    • 36248985213 scopus 로고    scopus 로고
    • Upstream processes in antibody production: evaluation of critical parameters
    • Jain E, Kumar A. Upstream processes in antibody production: evaluation of critical parameters. Biotechnol Adv. 2008; 26: 46-72.
    • (2008) Biotechnol Adv , vol.26 , pp. 46-72
    • Jain, E.1    Kumar, A.2
  • 6
    • 33745807268 scopus 로고    scopus 로고
    • Bioreactor systems for the production of biopharmaceuticals from animal cells
    • Warnock JN, Al-Rubeai M. Bioreactor systems for the production of biopharmaceuticals from animal cells. Biotechnol Appl Biochem. 2006; 45: 1-12.
    • (2006) Biotechnol Appl Biochem , vol.45 , pp. 1-12
    • Warnock, J.N.1    Al-Rubeai, M.2
  • 7
    • 0036606117 scopus 로고    scopus 로고
    • Dialysis-basedbioreactor systems for the production of monoclonal antibodies alternatives to ascites production in mice
    • Bruce MP, Boyd V, Duch C, White JR. Dialysis-basedbioreactor systems for the production of monoclonal antibodies alternatives to ascites production in mice. J Immunol Methods. 2002; 264: 59-68.
    • (2002) J Immunol Methods , vol.264 , pp. 59-68
    • Bruce, M.P.1    Boyd, V.2    Duch, C.3    White, J.R.4
  • 8
    • 0025465358 scopus 로고
    • Potential and problems of animal cells in suspension culture
    • Leist CH, Meyer HP, Fiechter A. Potential and problems of animal cells in suspension culture. J Biotechnol. 1990; 15: 1-46.
    • (1990) J Biotechnol , vol.15 , pp. 1-46
    • Leist, C.H.1    Meyer, H.P.2    Fiechter, A.3
  • 9
    • 33845948561 scopus 로고    scopus 로고
    • Packed-bed bioreactors for mammalian cell culture: bioprocess and biomedical applications
    • Meuwly F, Ruffieux PA, Kadouri A, von Stockar U. Packed-bed bioreactors for mammalian cell culture: bioprocess and biomedical applications. Biotechnol Adv. 2007; 25: 45-56.
    • (2007) Biotechnol Adv , vol.25 , pp. 45-56
    • Meuwly, F.1    Ruffieux, P.A.2    Kadouri, A.3    von Stockar, U.4
  • 10
    • 0028017817 scopus 로고
    • A comparison of monoclonal antibody productivity in different hollow fiber bioreactors
    • Lowrey D, Murphy S, Goffe RA. A comparison of monoclonal antibody productivity in different hollow fiber bioreactors. J Biotechnol. 1994; 36: 35-38.
    • (1994) J Biotechnol , vol.36 , pp. 35-38
    • Lowrey, D.1    Murphy, S.2    Goffe, R.A.3
  • 11
    • 0028141983 scopus 로고
    • Improvement of hemocompatibility on a cellulose dialysis membrane with a novel biomedical polymer having a phospholipid polar group
    • Ishihara K, Fukumoto K, Miyazaki H, Nakabayashi N. Improvement of hemocompatibility on a cellulose dialysis membrane with a novel biomedical polymer having a phospholipid polar group. Artif Organs. 1994; 18: 559-564.
    • (1994) Artif Organs , vol.18 , pp. 559-564
    • Ishihara, K.1    Fukumoto, K.2    Miyazaki, H.3    Nakabayashi, N.4
  • 12
    • 0002500678 scopus 로고
    • Microcarrier technology, present status and perspective
    • Van der Velden-de Groot CAM. Microcarrier technology, present status and perspective. Cytotechnology. 1995; 18: 51-56.
    • (1995) Cytotechnology , vol.18 , pp. 51-56
    • Van der Velden-de Groot, C.A.M.1
  • 13
    • 0346644893 scopus 로고
    • Novel anchorage matrices for suspension culture of mammalian cells
    • Bohak Z, Kadouri A, Sussman MV, Feldman AF. Novel anchorage matrices for suspension culture of mammalian cells. Biopolymers. 1987; 26 (Suppl): S205-S213.
    • (1987) Biopolymers , vol.26 , Issue.SUPPL.
    • Bohak, Z.1    Kadouri, A.2    Sussman, M.V.3    Feldman, A.F.4
  • 14
    • 0028403722 scopus 로고
    • Cultivation of anchorage-dependent mammalian cells and production of various metabolites
    • Kadouri A. Cultivation of anchorage-dependent mammalian cells and production of various metabolites. Colloids Surf B. 1994; 2: 265-272.
    • (1994) Colloids Surf B , vol.2 , pp. 265-272
    • Kadouri, A.1
  • 15
    • 56349113678 scopus 로고    scopus 로고
    • Synthesis and characterization of elastic and macroporous chitosan-gelatin cryogels for tissue engineering
    • Kathuria N, Tripathi A, Kar KK, Kumar A. Synthesis and characterization of elastic and macroporous chitosan-gelatin cryogels for tissue engineering. Acta Biomater. 2009; 5: 406-418.
    • (2009) Acta Biomater , vol.5 , pp. 406-418
    • Kathuria, N.1    Tripathi, A.2    Kar, K.K.3    Kumar, A.4
  • 16
    • 0344196813 scopus 로고    scopus 로고
    • Affinity fractionation of lymphocytes using a monolithic cryogel
    • Kumar A, Plieva FM, Galaev IY, Mattiasson B. Affinity fractionation of lymphocytes using a monolithic cryogel. J Immunol Methods. 2003; 283: 185-194.
    • (2003) J Immunol Methods , vol.283 , pp. 185-194
    • Kumar, A.1    Plieva, F.M.2    Galaev, I.Y.3    Mattiasson, B.4
  • 18
    • 70349771413 scopus 로고    scopus 로고
    • Synthesis and characterization of a temperature-responsive biocompatible poly(N-vinylcaprolactam) cryogel: a step towards designing a novel cell scaffold
    • Srivastava A, Kumar A. Synthesis and characterization of a temperature-responsive biocompatible poly(N-vinylcaprolactam) cryogel: a step towards designing a novel cell scaffold. J Biomater Sci Polym Ed. 2009; 20: 1393-1415.
    • (2009) J Biomater Sci Polym Ed , vol.20 , pp. 1393-1415
    • Srivastava, A.1    Kumar, A.2
  • 19
    • 33644894497 scopus 로고    scopus 로고
    • Integrated bioprocess for the production and isolation of urokinase from animal cell culture using supermacroporous cryogel matrices
    • Kumar A, Bansal V, Nandakumar KS, Galaev IY, Roychoudhury PK, Holmdahl R, Mattiasson B. Integrated bioprocess for the production and isolation of urokinase from animal cell culture using supermacroporous cryogel matrices. Biotechnol Bioeng. 2006; 93: 636-646.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 636-646
    • Kumar, A.1    Bansal, V.2    Nandakumar, K.S.3    Galaev, I.Y.4    Roychoudhury, P.K.5    Holmdahl, R.6    Mattiasson, B.7
  • 22
    • 67649095468 scopus 로고    scopus 로고
    • Designing supermacroporous cryogels based on polyacrylonitrile and a polyacrylamide-chitosan semi-interpenetrating network
    • Jain E, Kumar A. Designing supermacroporous cryogels based on polyacrylonitrile and a polyacrylamide-chitosan semi-interpenetrating network. J Biomater Sci Polym Ed. 2009; 20: 877-902.
    • (2009) J Biomater Sci Polym Ed , vol.20 , pp. 877-902
    • Jain, E.1    Kumar, A.2
  • 23
    • 34248587886 scopus 로고    scopus 로고
    • The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: mechanical strength and swelling/de-swelling kinetics
    • Srivastava A, Jain E, Kumar A. The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: mechanical strength and swelling/de-swelling kinetics. Mater Sci Eng A. 2007; 464: 93-100.
    • (2007) Mater Sci Eng A , vol.464 , pp. 93-100
    • Srivastava, A.1    Jain, E.2    Kumar, A.3
  • 24
    • 51249170678 scopus 로고
    • Antigenic determinants on chicken riboflavin carrier protein-a study with monoclonal-antibodies
    • Bangalore)
    • Velu NK, Karande AA, Adiga PR. Antigenic determinants on chicken riboflavin carrier protein-a study with monoclonal-antibodies. J Biosci. (Bangalore) 1992; 17: 151-165.
    • (1992) J Biosci , vol.17 , pp. 151-165
    • Velu, N.K.1    Karande, A.A.2    Adiga, P.R.3
  • 25
    • 0026553966 scopus 로고
    • A common epitope of beta-lactoglobulin and serum retinol-binding proteins: elucidation of its core sequence using synthetic peptides
    • Reddy BM, Karande AA, Adiga PR. A common epitope of beta-lactoglobulin and serum retinol-binding proteins: elucidation of its core sequence using synthetic peptides. Mol Immunol. 1992; 29: 511-516.
    • (1992) Mol Immunol , vol.29 , pp. 511-516
    • Reddy, B.M.1    Karande, A.A.2    Adiga, P.R.3
  • 27
    • 0039198616 scopus 로고
    • Automated HPLC monitoring of glucose, glutamine, lactate and alanine on suspended mammalian cell reactors
    • Favre E, Pugeaud P, Peringer P. Automated HPLC monitoring of glucose, glutamine, lactate and alanine on suspended mammalian cell reactors. Biotechnol Tech. 1990; 4: 315-320.
    • (1990) Biotechnol Tech , vol.4 , pp. 315-320
    • Favre, E.1    Pugeaud, P.2    Peringer, P.3
  • 28
    • 0014116315 scopus 로고
    • The determination of ammonia in whole blood by a direct colorimetric method
    • McCullough H. The determination of ammonia in whole blood by a direct colorimetric method. Clin Chim Acta. 1967; 17: 297-304.
    • (1967) Clin Chim Acta , vol.17 , pp. 297-304
    • McCullough, H.1
  • 29
    • 0022977313 scopus 로고
    • Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture
    • Miller WM, Lin AA, Wilke C, Blanch HW. Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture. Biotechnol Lett. 1986; 8: 463-468.
    • (1986) Biotechnol Lett , vol.8 , pp. 463-468
    • Miller, W.M.1    Lin, A.A.2    Wilke, C.3    Blanch, H.W.4
  • 30
    • 0028130107 scopus 로고
    • Polymer substrates for controlled biological interactions
    • Cima LG. Polymer substrates for controlled biological interactions. J Cell Biochem. 1994; 56: 155-161.
    • (1994) J Cell Biochem , vol.56 , pp. 155-161
    • Cima, L.G.1
  • 32
    • 0027383245 scopus 로고
    • Cell biology of hydrogels
    • Smetana K Jr. Cell biology of hydrogels. Biomaterials. 1993; 14: 1046-1450.
    • (1993) Biomaterials , vol.14 , pp. 1046-1450
    • Smetana Jr, K.1
  • 33
    • 17844367170 scopus 로고    scopus 로고
    • Inverted-colloidal-crystal hydrogel matrices as three-dimensional cell scaffolds
    • Zhang YJ, Wang SP, Eghtedari M, Motamedi M, Kotov NA. Inverted-colloidal-crystal hydrogel matrices as three-dimensional cell scaffolds. Adv Funct Mater. 2005; 15: 725-731.
    • (2005) Adv Funct Mater , vol.15 , pp. 725-731
    • Zhang, Y.J.1    Wang, S.P.2    Eghtedari, M.3    Motamedi, M.4    Kotov, N.A.5
  • 34
    • 18944365890 scopus 로고    scopus 로고
    • The influence of the chemical composition of cell culture material on the growth and antibody production of hybridoma cells
    • Heilmann K, Groth T, Behrsing O, Albrecht W, Schossig M, Lendlein A, Micheel B. The influence of the chemical composition of cell culture material on the growth and antibody production of hybridoma cells. J Biotechnol. 2005; 115: 291-301.
    • (2005) J Biotechnol , vol.115 , pp. 291-301
    • Heilmann, K.1    Groth, T.2    Behrsing, O.3    Albrecht, W.4    Schossig, M.5    Lendlein, A.6    Micheel, B.7
  • 35
    • 0038738155 scopus 로고    scopus 로고
    • Thermal response of poly(N-isopropylacrylamide) brushes probed by surface plasmon resonance
    • Balamurugan S, Mendez S, Balamurugan SS, O'Brien MJ, Lopez GP. Thermal response of poly(N-isopropylacrylamide) brushes probed by surface plasmon resonance. Langmuir. 2003; 19: 2545-2549.
    • (2003) Langmuir , vol.19 , pp. 2545-2549
    • Balamurugan, S.1    Mendez, S.2    Balamurugan, S.S.3    O'Brien, M.J.4    Lopez, G.P.5
  • 36
    • 75049085840 scopus 로고    scopus 로고
    • Macroporous interpenetrating cryogel network of poly(acrylonitrile) and gelatin for biomedical applications
    • Jain E, Srivastava A, Kumar A. Macroporous interpenetrating cryogel network of poly(acrylonitrile) and gelatin for biomedical applications. J Mater Sci Mater Med. 2009; 20: S173-S179.
    • (2009) J Mater Sci Mater Med , vol.20
    • Jain, E.1    Srivastava, A.2    Kumar, A.3
  • 37
    • 1142293806 scopus 로고    scopus 로고
    • Effects of three-dimensional culturing in a fibrous matrix on cell cycle, apoptosis and mAb production by hybridoma cells
    • Luo J, Yang ST. Effects of three-dimensional culturing in a fibrous matrix on cell cycle, apoptosis and mAb production by hybridoma cells. Biotechnol Prog. 2004; 20: 306-315.
    • (2004) Biotechnol Prog , vol.20 , pp. 306-315
    • Luo, J.1    Yang, S.T.2
  • 38
    • 0027205458 scopus 로고
    • Specific cell adhesion as potential cause of interactions between hybridoma cells and reactor surfaces
    • Gaertner JG, Dhurjati P. Specific cell adhesion as potential cause of interactions between hybridoma cells and reactor surfaces. Biotechnol Lett. 1993; 15: 803-808.
    • (1993) Biotechnol Lett , vol.15 , pp. 803-808
    • Gaertner, J.G.1    Dhurjati, P.2
  • 40
    • 9444286985 scopus 로고    scopus 로고
    • High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
    • Xie LZ, Wang DIC. High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor. Biotechnol Bioeng. 1996; 51: 725-729.
    • (1996) Biotechnol Bioeng , vol.51 , pp. 725-729
    • Xie, L.Z.1    Wang, D.I.C.2
  • 41
    • 0033751654 scopus 로고    scopus 로고
    • The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma
    • Barnabe N, Butler M. The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma. Cytotechnology 2000; 34: 47-57.
    • (2000) Cytotechnology , vol.34 , pp. 47-57
    • Barnabe, N.1    Butler, M.2
  • 42
    • 0027596218 scopus 로고
    • Fractional factorial study of hybridoma behavior. II. Kinetics of nutrient uptake and waste production
    • Gaertner JG, Dhurjati P. Fractional factorial study of hybridoma behavior. II. Kinetics of nutrient uptake and waste production. Biotechnol Prog. 1993; 9: 309-316.
    • (1993) Biotechnol Prog , vol.9 , pp. 309-316
    • Gaertner, J.G.1    Dhurjati, P.2
  • 43
    • 0026254349 scopus 로고
    • Growth, metabolic, and antibody production kinetics of hybridoma cell culture. II. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor
    • Ozturk SS, Palsson BO. Growth, metabolic, and antibody production kinetics of hybridoma cell culture. II. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnol Prog. 1991; 7: 481-494.
    • (1991) Biotechnol Prog , vol.7 , pp. 481-494
    • Ozturk, S.S.1    Palsson, B.O.2
  • 44
    • 0030088497 scopus 로고    scopus 로고
    • Analysis of nutritional factors and physical conditions affecting growth and monoclonal antibody production of the hybridoma KB-26.5 cell line
    • Sanfeliu A, Cairo JJ, Casas C, Sola C, Godia F. Analysis of nutritional factors and physical conditions affecting growth and monoclonal antibody production of the hybridoma KB-26.5 cell line. Biotechnol Prog. 1996; 12: 209-216.
    • (1996) Biotechnol Prog , vol.12 , pp. 209-216
    • Sanfeliu, A.1    Cairo, J.J.2    Casas, C.3    Sola, C.4    Godia, F.5
  • 45
    • 0028765762 scopus 로고
    • Induction of apoptosis in nutrient limited cultures of hybridoma cells
    • Mercille S, Massie B. Induction of apoptosis in nutrient limited cultures of hybridoma cells. Biotechnol Bioeng. 1994; 44: 1140-1154.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1140-1154
    • Mercille, S.1    Massie, B.2
  • 46
    • 14744298163 scopus 로고
    • Acoustic cell filter for high density perfusion culture of hybridoma cells
    • (N Y)
    • Trampler F, Sonderhoff SA, Pui PW, Kilburn DG, Piret JM. Acoustic cell filter for high density perfusion culture of hybridoma cells. Biotechnology. (N Y) 1994; 12: 281-284.
    • (1994) Biotechnology , vol.12 , pp. 281-284
    • Trampler, F.1    Sonderhoff, S.A.2    Pui, P.W.3    Kilburn, D.G.4    Piret, J.M.5
  • 47
    • 0027976952 scopus 로고
    • Scaleup of spinfilter perfusion bioreactor for mammalian-cell retention
    • Yabannavar VM, Singh V, Connelly NV. Scaleup of spinfilter perfusion bioreactor for mammalian-cell retention. Biotechnol Bioeng. 1994; 43: 159-164.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 159-164
    • Yabannavar, V.M.1    Singh, V.2    Connelly, N.V.3
  • 49
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng. 1992; 39: 418-431.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 418-431
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 50
    • 0025435131 scopus 로고
    • Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production
    • MacQueen A, Bailey JE. Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production. Biotechnol Bioeng. 1990; 35: 1067-1077.
    • (1990) Biotechnol Bioeng , vol.35 , pp. 1067-1077
    • MacQueen, A.1    Bailey, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.