Thyroid hormones (T3 and T4): Dual effect on human cancer cell proliferation

Anticancer Research

Volumn 31, Issue 1, 2011, Pages 89-96

  Moriggi, Giulia ^a,b   Falzacappa, Cecilia Verga ^a,b,c   Mangialardo, Claudia ^a,b   Michienzi, Simona ^a,b   Stigliano, Antonio ^a,b   Brunetti, Ercole ^b   Toscano, Vincenzo ^a   Misiti, Silvia ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b San Peter Hospital   (Italy)

^c Foundation for Diabetes Endocrinology and Metabolism (DEM)   (Italy)

Author keywords

MAPK; PI3K; Proliferation; Thyroid hormones

Indexed keywords

BETA CATENIN; BROXURIDINE; LIOTHYRONINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; THYROXINE;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL PROLIFERATION; CELL TYPE; GENE MUTATION; IMMUNOASSAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY;

BETA CATENIN; BLOTTING, WESTERN; CELL PROLIFERATION; GENE EXPRESSION; HUMANS; NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROXINE; TRIIODOTHYRONINE; TUMOR CELLS, CULTURED;

EID: 79851487947     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Hassan MM, Kaseb A, Li D, Patt YZ, Vauthey JN, Thomas MB, Curley SA, Spitz MR, Sherman SI, Abdalla EK, Davila M, Lozano RD, Hassan DM, Chan W, Brown TD and Abbruzzese JL: Association between hypothyroidism and hepatocellular carcinoma: a case control study in the United States. Hepatology 49(5): 1563-1570, 2009.
2. Cristofanilli M, Yamamura Y, Kau SW, Bevers T, Strom S, Patangan M, Hsu L, Krishnamurthy S, Theriault RL and Hortobagyi GN: Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer 103(6): 1122-1128, 2005.
3. Hercbergs AA, Goyal LK, Suh JH, Lee S, Reddy CA, Cohen BH, Stevens GH, Reddy SK, Peereboom DM, Elson PJ, Gupta MK and Barnett GH: Propylthiouracil- induced chemical hypothyroidism with high-dose tamoxifen prolongs survival in recurrent high-grade glioma: a phase I/II study. Anticancer Res 23(1B): 617-626, 2003. (Pubitemid 36358462)
4. Köhrle J: The selenoenzyme family of deiodinase isozymes controls local thyroid hormone availability. Rev Endocr Metab Disord 1(1-2): 49-58, 2000.
5. Davis PJ, Davis FB, Cody V et al: Membrane receptors mediating thyroid hormone action. Trends Endocrinol Metab 16(9): 429-435, 2005. (Pubitemid 41506950)
6. Cheng SY, Leonard JL and Davis PJ: Molecular aspects of thyroid hormone actions. Endocr Rev 31(2): 139-170, 2010.
7. Guigon CJ, Zhao L, Lu C, Willingham MC and Cheng SY: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. Mol Cell Biol 28(14): 4598-4608, 2008.
8. Hiroi Y, Kim HH, Ying H et al: Rapid nongenomic action of thyroid hormone. PNAS 103(38): 14104-14109, 2006. (Pubitemid 44452987)
9. Nakayama K, Nakayama N, Kurman RJ, Cope L, Pohl G, Samuels Y, Velculescu VE, Wang, TL and Shih Ie M: Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 5(7): 779-785, 2006. (Pubitemid 44775134)
10. Ihle NT, Lesmos R, Wipf P, Yacoub A, Mitchell C, Siwak D, Mills GB, Dent P, Kirkpatrick DL and Powis G: Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 69(1): 143-150, 2009.
11. Philp AJ, Campbell IG, Leet C, Vincan E, Rockman SP, Whitehead RH, Thomas RJS and Phillips WA: The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 61(20): 7426-7429, 2001. (Pubitemid 32995029)
12. Tissier F, Cavard C, Groussin L, Perlemoine K, Fumey G, Hagneré A-M, René-Corail F, Jullian E, Gicquel C, Bertagna X, Vacher-Lavenu M-C, Perret C and Bertherat J: Mutations of β-catenin in adrenocortical tumors: Activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res 65(17): 7622-7627, 2005. (Pubitemid 41297234)
13. Cheng SY: Isoform-dependent actions of thyroid hormone nuclear receptors: Lessons from knock-in mutant mice. Steroids - 70(5-7): 450-454, 2005.
14. Foster MP, Montecino-Rodriguez E and Dorshkind K: Proliferation of bone marrow pro-B-cells is dependent on stimulation by the pituitary/thyroid axis. J Immunol 163(11): 5883-5890, 1999.
15. Ohmura T, Katyal SL, Locker J, Ledda-Columbano GM, Columbano A and Shinozuka H: Induction of cellular DNA synthesis in the pancreas and kidneys of rats by peroxisome proliferators, 9-cis retinoic acid, and 3,3′,5-triiodo- L-thyronine. Cancer Res 57(5): 795-798, 1997. (Pubitemid 27097995)
16. Verga Falzacappa C, Panacchia L, Bucci B, Stigliano A, Cavallo MG, Brunetti E, Toscano V and Misiti S: 3,5,3′-Triiodo-L-thyronine (T3) is a survival factor for pancreatic beta-cells undergoing apoptosis. J Cell Physiol 206(2): 309-321, 2006. (Pubitemid 43062798)
17. Verga Falzacappa C, Petrucci E, Patriarca V, Michienzi S, Stigliano A, Brunetti E, Toscano V and Misiti S: Thyroid hormone receptor TRbetal mediates Akt activation by T3 in pancreatic beta cells. J Mol Endocrinol 38(1-2): 221-233, 2007. (Pubitemid 46351605)