17β-estradiol augments 18F-FDG uptake and glycolysis of T47D breast cancer cells via membrane-initiated rapid PI3K-Akt activation

Journal of Nuclear Medicine

Volumn 51, Issue 11, 2010, Pages 1740-1747

  Ko, Bong Ho ^a   Paik, Jin Young ^a   Jung, Kyung Ho ^a   Lee, Kyung Han ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

18F FDG; Akt; Breast cancer; Estrogen; Hexokinase; PI3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 HYDROXYESTRADIOL; ANTIESTROGEN; CYCLOHEXIMIDE; ESTROGEN RECEPTOR; FLUORODEOXYGLUCOSE F 18; FULVESTRANT; GLUCOSE TRANSPORTER 1; HEXOKINASE; LACTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; WORTMANNIN; DIAGNOSTIC AGENT; ESTRADIOL; ESTROGEN;

ARTICLE; BREAST CANCER; CALCIUM METABOLISM; CANCER CELL CULTURE; CONTROLLED STUDY; DISEASE MARKER; DRUG UPTAKE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TREATMENT RESPONSE; ANIMAL; BREAST TUMOR; CATTLE; CELL MEMBRANE; CELL PROLIFERATION; DRUG EFFECT; ENZYMOLOGY; KINETICS; METABOLISM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CATTLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; ENZYME ACTIVATION; ESTRADIOL; ESTROGENS; FLUORODEOXYGLUCOSE F18; GLYCOLYSIS; HEXOKINASE; HUMANS; KINETICS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 79851485459     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.074708     Document Type: Article

References (34)

1. Avril NE, Weber WA. Monitoring response to treatment in patients utilizing PET. Radiol Clin North Am. 2005;43:189-204. (Pubitemid 40326568)
2. 18F]FDG-PET-CT for early monitoring of tumor response: when and why. Q J Nucl Med Mol Imaging. 2009;53:167-180.
3. Zhao B, Schwartz LH, Larson SM. Imaging surrogates of tumor response to therapy: anatomic and functional biomarkers. J Nucl Med. 2009;50:239-249.
4. Weber WA. Positron emission tomography as an imaging biomarker. J Clin Oncol. 2006;24:3282-3292. (Pubitemid 46622068)
5. 18F]fluorodeoxyglucose. J Clin Oncol. 2009;27:535-541.
6. Pons F, Duch J, Fuster D. Breast cancer therapy: the role of PET-CT in decision making. Q J Nucl Med Mol Imaging. 2009;53:210-223.
7. Dehdashti F, Flanagan FL, Mortimer JE, et al. Positron emission tomographic assessment of "metabolic flare" to predict response of metastatic breast cancer to antiestrogen therapy. Eur J Nucl Med. 1999;26:51-56.
8. Mortimer JE, Dehdashti F, Siegel BA, et al. Metabolic flare: indicator of hormone responsiveness in advanced breast cancer. J Clin Oncol. 2001;19:2797-2803. (Pubitemid 32538187)
9. Dehdashti F, Mortimer JE, Trinkaus K, et al. PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor- positive breast cancer. Breast Cancer Res Treat. 2009;113:509-517.
10. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006;354:270-282.
11. Generali D, Buffa FM, Berruti A, et al. Phosphorylated ERα, HIF-1α, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer. J Clin Oncol. 2009;27:227-234.
12. 13C NMR studies. Proc Natl Acad Sci USA. 1989;86:5585-5589.
13. 13C nuclear magnetic resonance spectroscopy studies. Mol Pharmacol. 1991;40:1029-1035.
14. Rivenzon-Segal D, Boldin-Adamsky S, Seger D, Seger R, Degani H. Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer. Int J Cancer. 2003;107:177-182. (Pubitemid 37152894)
15. Grover-McKay M, Walsh SA, Seftor EA, Thomas PA, Hendrix MJ. Role for glucose transporter 1 protein in human breast cancer. Pathol Oncol Res. 1998;4:115-120. (Pubitemid 28394627)
16. 3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells. Nucl Med Biol. 1998;25:481-485.
17. 18F]-D-glucose. Cancer. 1998;82:2227-2234.
18. Frezza C, Cipolat S, Scorrano L. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc. 2007;2:287-295. (Pubitemid 47040043)
19. Zhou M, Sevilla L, Vallega G, et al. Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol Endocrinol Metab. 1998;275:E187-E196.
20. Arora KK, Pedersen PL. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism: evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J Biol Chem. 1988;263:17422-17428. (Pubitemid 19029327)
21. Vander Heiden MG, Cantely LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029-1033.
22. Fanciulli M, Paggi MG, Bruno T, et al. Glycolysis and growth rate in normal and in hexokinase transfected NIH-3T3 cells. Oncol Res. 1994;6:405-409.
23. Rivenzon-Segal D, Rushkin E, Polak-Charcon S, Degani H. Glucose transporters and transport kinetics in retinoic acid-differentiated T47D human breast cancer cells. Am J Physiol Endocrinol Metab. 2000;279:E508-E519.
24. Aloj L, Caraco C, Jagoda E, Eckelman WC, Neumann RD. Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture. Cancer Res. 1999;59:4709-4714. (Pubitemid 29428980)
25. Collins P, Webb C. Estrogen hits the surface. Nat Med. 1999;5:1130-1131. (Pubitemid 29474415)
26. Levin ER, Pietras RJ. Estrogen receptors outside the nucleus in breast cancer. Breast Cancer Res Treat. 2008;108:351-361. (Pubitemid 351431076)
27. Brzozowski AM, Pike ACW, Dauter Z, et al. Molecular basis of agonism and antagonism in the estrogen receptor. Nature. 1997;389:753-758. (Pubitemid 27458965)
28. Björnström L, Sjöberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 2005;19:833-842. (Pubitemid 40397050)
29. Filardo E, Quinn J, Pang Y, et al. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology. 2007;148:3236-3245. (Pubitemid 46997004)
30. Castoria G, Migliaccio A, Bilancio A, et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 2001;20:6050-6059. (Pubitemid 33049280)
31. Elstrom RL, Bauer DE, Buzzai M, et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 2004;64:3892-3899. (Pubitemid 38697301)
32. Robey RB, Hay N. Is Akt the "Warburg kinase"?: Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol. 2009;19:25-31.
33. Lin CY, Ding HJ, Liu CS, et al. Correlation between the intensity of breast FDG uptake and menstrual cycle. Acad Radiol. 2007;14:940-944.
34. Sánchez-Muñoz A, Pérez-Ruiz E, Jiménez B, et al. Targeted therapy of metastatic breast cancer. Clin Transl Oncol. 2009;11:643-650.