Nitrogen and sulphur mustard induced histopathological observations in mouse visceral organs

Journal of Environmental Biology

Volumn 31, Issue 6, 2010, Pages 891-905

  Sharma, Manoj ^a   Pant, S C ^a   Pant, J C ^b   Vijayaraghavan, R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

^b KUMAUN UNIVERSITY   (India)

Author keywords

Acute toxicity; Mechlorethamine; Nitrogen mustard; Oxidative stress PDF of full length paper is available online; Percutaneous; Subcutaneous; Sulphur mustard

Indexed keywords

CHEMICAL POLLUTANT; DICOTYLEDON; FREE RADICAL; HISTOPATHOLOGY; LESION; NITROGEN; SULFUR; TOXICITY;

ANIMALIA; BRASSICACEAE; MUS;

EID: 79851475198     PISSN: 02548704     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. th Eds. McGraw-Hill medical publishing division, USA. pp. 1315-1403 (2006).
2. Dabrowska, M.I., L.L. Becks, J.L. Lelli, M.G. Levee and D.B. Hinshaw: Sulfur mustard induced apoptosis and necrosis in endothelial cells. Toxicol. Appl. Pharmacol., 141, 568-583 (1996).
3. Das, S.K., S. Mukherjee, M.G. Smith and D. Chatterjee: Prophylactic protection by N-acetyl cysteine against the pulmonary injury induced by 2-chloroethyl ethyl sulphide, a mustard analogue. J. Biochem. Mol. Toxicol., 17, 177-184 (2003).
4. Gautam, A., R. Vijayaraghavan, M. Sharma and K. Ganesan: Comparative toxicity studies of sulphur mustard (2,2-dichloro diethyl sulphide) and monofunctional sulphur mustard (2-chloro ethyl sulphide) administered through various routes. J. Med. CBRN Def., 4, 1-21 (2006).
5. Gilman, A. and P.S. Philips: The biological actions and therapeutic applications of the β-chloroethyl amines and sulfides. Science (Wash. DC), 103, 409-415 (1946).
6. Gilman, A., F.S. Philips and E.S. Koelle: The renal clearance of thiosulphate with obersvations on its volume distribution. Am. J. Physiol., 148, 348-357 (1946).
7. Giuliani, I., A. Baeza-Squiban and F. Marano: Early cytotoxic effects of chlorethamine, a nitrogen mustard, on mammalian airway epithelium. Toxicol. In Vitro., 11, 695-702 (1997).
8. Gunhan, O., B. Kart, T. Karayilanozlu, L. Kenar and B. Celasun: Morphological and immunohistochemical changes on rat skin exposed to nitrogen mustard. Mil. Med., 169, 7-10 (2004).
9. Han, S., L.A. Espinoza, H. Liao, A.H. Boulares and M.E. Samulson: Protection by antioxidants aganist toxicity and apoptosis induced by the sulphur mustard analog 2-chloro ethyl sulphide (CEES) in Jurkat T Cells and normal human lymphocytes. Br. J. Pharmacol., 141, 795-802 (2004).
10. Jafari, M.: Dose and time dependent effects of sulphur mustard on antioxidant system in liver and brain of rat. Toxicol., 231, 30-39 (2007).
11. Khan, S., J.J. Ramwani and P.J. O'Brien: Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs. Role of lipid peroxidation. Biochem. Pharmacol., 43, 1963-1967 (1992).
12. Kumar, O., K. Sugendran and R. Vijayaraghavan: Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chem. Biol. Interact, 134, 1-12 (2001).
13. Luster, M.L., A.E. Munson and P.T. Thomas: Development of testing battery to assess chemical induced immunotoxicity : National toxicology programmes guidelines for immunotoxicology evaluation in mice. Fundam. Appl. Toxicol., 19, 2-19 (1998).
14. Masta, A., P.J. Gray and D.R. Phillips: Nitrogen mustard inhibits transcription and translation in a cell free system. Nucleic Acids Res., 23, 35083515 (1995).
15. Mattes, W.B., J.A. Hartley and K.W. Kohn: DNA sequence selectivity of guanine-N7 alkylatton by nitrogen mustards. Nucleic Acids Res., 14, 2971-2987 (1986).
16. McMannus, J.F.A. and R.W. Mowry: General methods for study of the cell and it's structure. Irr. Staining methods: Histologic and Histochemical. Harper, New York. pp. 73-90 (1965).
17. Pant, S.C. and R. Vijayaraghavan: Histomorphological and histochemical alterations following short-term inhalation exposure to sulfur mustard on visceral organs of mice. Biomed. Environ. Sci, 12, 201-213 (1999).
18. Papirmeister, B., A.F. Feister, S.I. Robinson and R.D. Ford: Medical defense against Mustard Gas: Toxic Mechanisms and Pharmacological Implications. CRC Press, Boca Raton, F.L. (1991).
19. Papirmeister, B., C.L. Gross, H.L. Meier, J.P. Petrali and J.B. Jhonson: Molecular basis for sulphur mustard induced vesication. Fund Appl. Toxicol., 5, S134-S149 (1985).
20. Rao, P.V.L., R. Vijayaraghavan and A.S.B. Bhaskar: Sulphur mustard induced DNA damage in mice after dermal and inhalational exposure. Toxicol., 139, 39-57 (1999).
21. Rappeneau, S., A. Baeza-Squiban, F. Braut-Boucher, M. Aubery, M.C Gendron and F. Marano: Use of fluorescent probes to assess the early sulfhydryl depletion and oxidative stress induced by mechlorethamine on airway epithelium. Toxicol. In vitro, 13, 765-771 (1999).
22. Sharma, M., R. Vijayaraghavan and K. Ganeshan: Comparison of toxicity of selected mustard agents by percutaneous and subcutaneous routes. Ind. J. Exp. Biol., 46, 822-830 (2008).
23. Somani, S.M. and R. Babu: Toxicodynamics of sulphur mustard. Int. J. Clin. Pharmacol. Ther. Toxicol., 27, 419-435 (1989).
24. Somani, S.M.: Chemical warfare agents. Academic Press, London (1992).
25. Sugendran, K., K. Jeevaratnam, A.S.B. Bhaskar and S.C. Pant: Effect of topically applied sulphur mustard on haematological, biochemical and histological parameters in mice. Def. Sci J., 46, 149-157 (1996).
26. Venkateswaran, K.S., V. Neerja, K. Sugendran, N. Gopalan, R. Vijayaraghavan, S.C. Pant, A.O. Prakash and R.C. Malhotra: Dose dependent effects on lymphoid organs following a single dermal application of sulphur mustard in mice. Human Exp. Toxicol., 13, 247-251 (1994).
27. Vijayaraghavan, R., A. Kulkarni, S.C. Pant, K. Pravin, P.V.L. Rao, N. Gupta, A. Gautam and K. Ganesan: Differential toxicity of sulphur mustard administered through percutaneous, subcutaneous and oral routes. Toxicol. Appl. Pharmacol., 202, 180-188 (2005).
28. Vijayaraghavan, R., K. Sugendran, S.C. Pant, K. Hussain and R.C. Malhotra: Dermal intoxication of mice with bis (2-chloroethyl) sulphide and the protective effects of flavonoids. Toxicol., 69, 35-42 (1991).
29. Vijayaraghavan, R., P. Kumar, U. Joshi, S.K. Raja, Rao Lakshmana, P.V. Malhotra, R.C. and D.K. Jaiswal: Prophylactic efficacy of amifostine and its analoges against sulphur mustard toxicity. Toxicol., 163, 83-91 (2001).
30. Vojvodic, V., Z. Milosavljevic, B. Boskovic and N. Bojanic: The protective effect of different drugs in rats poisoned by sulphur and nitrogen mustards. Fundam. Appl. Toxicol., 5, S160-S168 (1985).
31. Wheeler, G.P.: Studies related to the mechanism of action of cytotoxic alkylating agents: A review. Cancer Res., 22, 651-688 (1962).
32. Wormser, U.: Toxicology of mustard gas. Trends Pharmacol. Sci, 12, 164-167 (1991).