The label-free unambiguous detection and symbolic display of single nucleotide polymorphisms on DNA origami

Nano Letters

Volumn 11, Issue 2, 2011, Pages 910-913

  Subramanian, Hari K K ^a   Chakraborty, Banani ^a   Sha, Ruojie ^a   Seeman, Nadrian C ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

atomic force microscopy; direct readout of SNPs; DNA branch migration; DNA origami; photo cleavable linkers; Single nucleotide polymorphism detection

Indexed keywords

BRANCH MIGRATION; DIRECT READOUT OF SNPS; GENETIC VARIATION; GRAPHICAL REPRESENTATIONS; HUMAN GENOMES; KINETIC METHOD; LABEL FREE; PHOTO-CLEAVABLE LINKERS; PROBE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM DETECTION; SINGLE NUCLEOTIDE POLYMORPHISMS;

ATOMIC FORCE MICROSCOPY; DNA; GENES; NUCLEIC ACIDS; POLYMORPHISM; PROBES;

NUCLEOTIDES;

DNA;

ARTICLE; ATOMIC FORCE MICROSCOPY; DNA SEQUENCE; GENETICS; METHODOLOGY; NANOTECHNOLOGY; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STAINING;

DNA; DNA MUTATIONAL ANALYSIS; MICROSCOPY, ATOMIC FORCE; NANOTECHNOLOGY; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; STAINING AND LABELING;

EID: 79851471472     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl104555t     Document Type: Article

References (15)

1. Collins, F. S.; Brooks, L. D.; Chakravarti, A. Genome Res. 1998, 8, 1229-31
2. Collins, F. S.; Morgan, M.; Patrinos, A. Science 2003, 300, 286-90
3. Kim, S; Misra, A. Ann. Rev. Biomed. 2007, Eng. 9, 289-320
4. Wang, S. Q.; Wang, X. H.; Chen, S. H.; Guan, W. Anal. Biochem. 2002, 309, 206-211
5. Panyutin, I. G.; Hsieh, P. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 2021-2025
6. Seeman, N. C. Trends Biochem. Sci. 2005, 30, 119-125
7. Yurke, B.; Turberfield, A. J.; Mills, A. P., Jr.; Simmel, F. C.; Neumann, J. L. Nature 2000, 406, 605-608
8. Rothemund, P. W. K. Nature 2006, 440, 297-302
9. Ke, Y.; Lindsay, S.; Chang, Y.; Liu, Y.; Yan, H. Science 2008, 319, 180-183
10. Zhang, Z.; Zeng, D.; Ma, H.; Feng, G.; Hu, J.; He, L.; Li, C.; Fan, C. Small 2010, 6, 1854-1858
11. Buck, A. H.; Campbell, C. J.; Dickinson, P.; Mountford, C. P.; Stoquert, H. C.; Terry, J. G.; Evans, S. A. G.; Keane, L. M.; Su, T.-J.; Mount, A.,R.; Walton, A. J.; Beattie, J. S.; Crain, J.; Ghazal, P. Anal. Chem. 2007, 79, 4724-2728
12. Chakraborty, B. Ph.D. Thesis, New York University, 2008).
13. Source code can be downloaded at http://code.google.com/p/pado.
14. Stolz, M.; Gottardi, R.; Raiteri, R.; Miot, S.; Martin, I.; Imer, R.; Staufer, U.; Raducanu, A.; Duggelin, M.; Baschong, W.; Daniels, A. U.; Friedrich, N. F.; Aszodi, A.; Aebi, U. Nat. Nanotechnol. 2009, 4, 188-192
15. Liu, W.; Zhong, H.; Wang, R.; Seeman, N. C. Angew. Chem., 2011, in press (DOI: 10.1002/anie.201005911).