Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production

Medical Hypotheses

Volumn 76, Issue 3, 2011, Pages 325-327

  Chen, Xiao ^a   Zuo, Qiao ^a   Hai, Yuedong ^b   Sun, Xue Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; HYDROGEN; LACTULOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; COLITIS; HUMAN; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS;

ANIMALS; ANTIOXIDANTS; CONSTIPATION; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN; INFLAMMATORY BOWEL DISEASES; LACTULOSE; MICE;

EID: 79751538420     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2010.09.026     Document Type: Article

References (27)

1. Carty E., Rampton D.S. Evaluation of new therapies for inflammatory bowel disease. J Clin Pharmacol 2003, 56(4):351-361.
2. Karp S.M., Koch T.R. Oxidative stress and antioxidants in inflammatory bowel disease. Dis Mon 2006, 52(5):199-207.
3. Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006, 72(11):1493-1505.
4. Moe K.T., Aulia S., Jiang F., Chua Y.L., Koh T.H., Wong M.C., et al. Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells. J Cell Mol Med 2006, 10(1):231-239.
5. Grisham M.B., Granger D.N. Neutrophil-mediated mucosal injury: role of reactive oxygen metabolites. Dig Dis Sci 1998, 33(3S):6S-15S.
6. Suematsu M., Suzuki M., Kitahora T., Miura S., Suzuki K., Hibi T., et al. Increased respiratory burst of leukocytes in inflammatory bowel diseases-the analysis of free radical generation by using chemiluminescence probe. J Clin Lab Immunol 1987, 24(3):125-128.
7. Korenaga D., Takesue F., Kido K., Yasuda M., Inutsuka S., Honda M., et al. Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice. J Surg Res 2002, 102(2):144-149.
8. Oz H.S., Chen T.S., McClain C.J., de Villiers W.J. Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem 2005, 16(5):297-304.
9. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., Nishimaki K., Yamagata K., et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007, 13(6):688-694.
10. Hayashida K., Sano M., Ohsawa I., Shinmura K., Tamaki K., Kimura K., et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008, 373(1):30-35.
11. Fukuda K., Asoh S., Ishikawa M., Yamamoto Y., Ohsawa I., Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007, 361(3):670-674.
12. Buchholz B.M., Kaczorowski D.J., Sugimoto R., Yang R., Wang Y., Billiar T.R., et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant 2008, 8(10):1-10.
13. Gharib B., Hanna S., Abdallahi O.M., Lepidi H., Gardette B., De Reggi M. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. CR Acad Sci III 2001, 324(8):719-724.
14. Chen H., Sun Y.P., Li Y., Liu W.W., Xiang H.G., Fan L.Y., et al. Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun 2010, 393(2):308-313.
15. Kajiya M., Silva M.J., Sato K., Ouhara K., Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun 2009, 386(1):11-15.
16. Voskuijl W., de Lorijn F., Verwijs W., Hogeman P., Heijmans J., Mäkel W., et al. PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial. Gut 2004, 53(11):1590-1594.
17. Florent C., Flourie B., Leblond A., Rautureau M., Bernier J.J., Rambaud J.C. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). J Clin Invest 1985, 75(2):608-613.
18. Rhodes J.M., Middleton P., Jewell D.P. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scand J Gastroenterol 1979, 14(3):333-336.
19. Rumi G., Tsubouchi R., Okayama M., Kato S., Mózsik G., Takeuchi K. Protective effect of lactulose on dextran sulfate sodium-induced colonic inflammation in rats. Dig Dis Sci 2004, 49(9):1466-1472.
20. Barnich N., Carvalho F.A., Glasser A.L., Darcha C., Jantscheff P., Allez M., et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 2007, 117(6):1566-1574.
21. Johansson M.E.V., Phillipson M., Petersson J., Holm L., Velcich A., Hansson G.C. The inner of the two Muc2 mucin dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci 2008, 105(39):15064-15069.
22. Johansson M.E.V., Gustafsson J.K., Sjöberg K.E., Petersson J., Holm L., et al. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS ONE 2010, 5(8):e12238. 10.1371/journal.pone.001223.
23. Elson C.O., Cong Y., McCracken V.J., Dimmitt R.A., Lorenz R.G., Weaver C.T. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 2005, 206:260-276.
24. Madsen K.L., Doyle J.S., Tavernini M.M., Jewell L.D., Rennie R.P., Fedorak R.N. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 2000, 118(6):1094-1105.
25. Feller M., Huwiler K., Schoepfer A., Shang A., Furrer H., Egger M. Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials. Clin Infect Dis 2010, 50(4):473-480.
26. Suzuki Y., Sano M., Hayashida K., Ohsawa I., Ohta S., Fukuda K. Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?. FEBS Lett 2009, 583(13):2157-2159.
27. Kajiyama S., Hasegawa G., Asano M., Hosoda H., Fukui M., Nakamura N., et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 2008, 28(3):137-143.