Chemoenzymatic synthesis of 2-arachidonoylglycerol, an endogenous ligand for cannabinoid receptors

Tetrahedron Letters

Volumn 52, Issue 11, 2011, Pages 1149-1150

  Vadivel, Subramanian K ^a   Whitten, Kyle M ^a   Makriyannis, A ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

2 Arachidonoylglycerol; Biocatalysis; Cannabinoid; Endogenous ligand

Indexed keywords

2 ARACHIDONOYLGLYCEROL; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; TRIACYLGLYCEROL LIPASE;

ARTICLE; BIOCATALYSIS; CANDIDA ANTARCTICA; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME IMMOBILIZATION; ENZYME MECHANISM; LIGAND BINDING; NONHUMAN; REACTION ANALYSIS;

CANDIDA ANTARCTICA;

EID: 79751535067     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.01.047     Document Type: Article

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19. 3, 500 MHz) δ 4.12-4.27 (m, 4H), 4.03-4.12 (m, 1H), 2.20-2.41 (t, J = 7.4 Hz, 4H), 1.67 (sxt, J = 7.42 Hz, 4H), 0.96 (t, J = 7.32 Hz, 6H)
20. C.D. Magnusson, and C.G. Haraldsson Tetrahedron 66 2010 2728
21. 3, 100 MHz) δ 173.3, 172.8 (2C), 130.7, 129.2, 128.9, 128.8, 128.5, 128.3, 128.0, 127.7, 69.2, 62.3 (2C), 36.1 (2C), 33.8, 31.7, 29.5, 27.4, 26.7, 25.8 (3C), 24.9, 22.8, 18.5 (2C), 14.3, 13.8 (2C).
22. 3, 100 MHz) δ 174.1, 130.7, 129.3, 128.9, 128.8, 128.5, 128.3, 128.1, 127.8, 75.2, 62.5 (2C), 33.8, 31.7, 29.6, 27.4, 26.7, 25.8, 25.8, 25.8, 24.9, 22.8, 14.3.