Mycophenolate mophetil therapy for chronic immune thrombocytopenic purpura resistant to steroids, immunosuppressants, and/or splenectomy in adults

Platelets

Volumn 22, Issue 2, 2011, Pages 153-156

  Colovic M ^a,b   Suvajdzic, N ^a,b   Colovic N ^a,b   Tomin, D ^a,b   Vidovic A ^a,b   Palibrk, V ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Chronic immune thrombocytopenia; corticosteroids; mycophenolate mophetil; splenectomy; unresponsive

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN A; DANAZOL; DAPSONE; DEXAMETHASONE; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PREDNISONE; VINCRISTINE;

ADULT; AGE DISTRIBUTION; ARTICLE; BLEEDING; BRONCHOPNEUMONIA; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DISEASE DURATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERABILITY; ELECTROLYTE DISTURBANCE; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; KIDNEY DYSFUNCTION; LEUKOCYTE COUNT; MALE; MULTIPLE CYCLE TREATMENT; PATIENT COMPLIANCE; PRIORITY JOURNAL; RELAPSE; REMISSION; SEX DIFFERENCE; SIDE EFFECT; SPLENECTOMY; THROMBOCYTE COUNT; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; CHRONIC DISEASE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PREDNISONE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SPLENECTOMY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79751522897     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2010.520372     Document Type: Article

References (13)

1. Olsson B, Andersson PO, Jernas M, Jacobsson S, Carlsson B, Carlsson LM, Wadenvik H. T-cell mediated cytotoxicity towards platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003;9:1123-1124. (Pubitemid 37173694)
2. Coopamah MD, Garvey MB, Freedman J, Semple JW. Cellular immune mechanisms in autoimmune thrombocytopenia purpura: An update. Transfus Med Rev 2003;17:69-80. (Pubitemid 36042646)
3. McMillan R, Durette C. Long-term outcomes in adults with chronic ITP after splenectomy failure. Blood, 2004;104:956-960. (Pubitemid 39038013)
4. Portielje JE, Westendorp RG, Kluin-Nelermans HC, Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 2001;97:2549-2554.
5. Hou P, Peng HJ, Shi Y, Zhang C, Qin P, Zhao C, Ji X, Wang X, Zhang M. Mycophenolate mophetil (MMF) for the treatment steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol 2003;70:353-357. (Pubitemid 36713929)
6. Howard J, Hoffbrand AV, Prentice HG, Mehta A. Mycophenolate mophetil for the treatment of refractory autoimmune haemolytic anaemia and autoimmune thrombocytopenia purpura. Br J Haematol 2002;117:712-715. (Pubitemid 34539252)
7. Zhang W, Ji L, Cao X, Chen Y, He A, Liu J, Zhao W, Zou S. Mycophenolate mophetil as a treatment for refractory idiopathic thrombocytopenic purpura. Acta Pharmacologica Sinica 2005;26:598-602. (Pubitemid 40676172)
8. Provan D, Moss AJ, Newland AC, Bussel JB. Efficacy of mycophenolate mophetil as single agent therapy for refractory immune thrombocytopenia purpura. Am J Hematol 2006;81:19-25. (Pubitemid 43077209)
9. Arnold DM, Nazi I, Santos A, Chan H, Heddle NM, Warkentin TE, Kelton JG. Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura. Blood 2010;115:29-31.
10. Allison AC. Immunosuppressive drugs: the first 50 years and a glance forward. Immunopharmacology 2000;47:63-83. (Pubitemid 30394533)
11. George JN, Woolf SH, Raskob GE, Wasser JS, Aledort LM, Ballem PJ, et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996;88:3:3-40. (Pubitemid 26230668)
12. British Committee for standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003;120:574-596.
13. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton- Maggs P, Bussel JB, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-186.